Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTLL8 Gene

Aliases for TTLL8 Gene

  • Tubulin Tyrosine Ligase Like 8 2 3 5
  • Tubulin Tyrosine Ligase-Like Family Member 8 2
  • Tubulin--Tyrosine Ligase-Like Protein 8 4
  • EC 6.3.2.- 4

External Ids for TTLL8 Gene

Previous GeneCards Identifiers for TTLL8 Gene

  • GC22M048795
  • GC22M050453
  • GC22M033351

Summaries for TTLL8 Gene

GeneCards Summary for TTLL8 Gene

TTLL8 (Tubulin Tyrosine Ligase Like 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-glycine ligase activity and sigma factor antagonist activity. An important paralog of this gene is TTLL3.

UniProtKB/Swiss-Prot for TTLL8 Gene

  • Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).

Additional gene information for TTLL8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL8 Gene

Genomics for TTLL8 Gene

GeneHancer (GH) Regulatory Elements for TTLL8 Gene

Promoters and enhancers for TTLL8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I050056 Enhancer 0.9 Ensembl ENCODE 550.8 +0.0 4 5.7 CTCF BACH1 SIN3A EBF1 RAD21 HIC1 ZFHX2 ZNF316 GLIS2 POLR2A TTLL8 ENSG00000273253 MOV10L1 SELENOO ARSA MLC1 IL17REL
GH22I050009 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +45.6 45568 8.7 HDGF RB1 ZSCAN4 BATF RAD21 EGR1 SCRT2 ZNF143 ZNF207 ATF7 IL17REL PIM3 MLC1 ENSG00000273253 CHKB TUBGCP6 HDAC10 TTLL8
GH22I050029 Enhancer 1 Ensembl ENCODE 0.3 +28.2 28243 2.3 RB1 ARID4B KLF17 ZNF2 ZNF48 RAD21 GLIS2 ARID2 ZNF143 ZNF391 MOV10L1 IL17REL TTLL8
GH22I050027 Enhancer 0.7 ENCODE 0.3 +31.1 31075 0.8 ZNF687 CLOCK NFIB MAX SIN3A MNT ELF1 GATA3 MTA1 TARDBP ENSG00000273253 IL17REL TTLL8
GH22I050018 Enhancer 0.4 ENCODE 0.3 +40.0 39998 1.1 MLLT1 ZNF507 EZH2 PIM3 MLC1 CHKB IL17REL TTLL8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTLL8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTLL8 gene promoter:

Genomic Locations for TTLL8 Gene

Genomic Locations for TTLL8 Gene
chr22:50,015,123-50,059,132
(GRCh38/hg38)
Size:
44,010 bases
Orientation:
Minus strand
chr22:50,453,552-50,495,364
(GRCh37/hg19)

Genomic View for TTLL8 Gene

Genes around TTLL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL8 Gene

Proteins for TTLL8 Gene

  • Protein details for TTLL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6PVC2-TTLL8_HUMAN
    Recommended name:
    Protein monoglycylase TTLL8
    Protein Accession:
    A6PVC2
    Secondary Accessions:
    • B5MDV0

    Protein attributes for TTLL8 Gene

    Size:
    850 amino acids
    Molecular mass:
    94676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL8 Gene

Post-translational modifications for TTLL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL8 Gene

No data available for DME Specific Peptides for TTLL8 Gene

Domains & Families for TTLL8 Gene

Gene Families for TTLL8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL8 Gene

Suggested Antigen Peptide Sequences for TTLL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTLL8: view

No data available for UniProtKB/Swiss-Prot for TTLL8 Gene

Function for TTLL8 Gene

Molecular function for TTLL8 Gene

UniProtKB/Swiss-Prot Function:
Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).

Enzyme Numbers (IUBMB) for TTLL8 Gene

Phenotypes From GWAS Catalog for TTLL8 Gene

Gene Ontology (GO) - Molecular Function for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0070735 protein-glycine ligase activity TAS --
GO:0070736 protein-glycine ligase activity, initiating ISS --
genes like me logo Genes that share ontologies with TTLL8: view
genes like me logo Genes that share phenotypes with TTLL8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TTLL8

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTLL8 Gene

Localization for TTLL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL8 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL8 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
genes like me logo Genes that share ontologies with TTLL8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TTLL8 Gene

Pathways & Interactions for TTLL8 Gene

SuperPathways for TTLL8 Gene

No Data Available

Interacting Proteins for TTLL8 Gene

Gene Ontology (GO) - Biological Process for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation TAS --
GO:0060271 cilium assembly IEA --
genes like me logo Genes that share ontologies with TTLL8: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL8 Gene

Drugs & Compounds for TTLL8 Gene

No Compound Related Data Available

Transcripts for TTLL8 Gene

mRNA/cDNA for TTLL8 Gene

(4) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL8 Gene

No ASD Table

Relevant External Links for TTLL8 Gene

GeneLoc Exon Structure for
TTLL8
ECgene alternative splicing isoforms for
TTLL8

Expression for TTLL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL8 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL8 Gene

This gene is overexpressed in Testis (x50.8).

Protein differential expression in normal tissues from HIPED for TTLL8 Gene

This gene is overexpressed in Pancreatic juice (54.4) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTLL8 Gene



Protein tissue co-expression partners for TTLL8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL8 Gene:

TTLL8
genes like me logo Genes that share expression patterns with TTLL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL8 Gene

Orthologs for TTLL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL8 33
  • 94.55 (n)
dog
(Canis familiaris)
Mammalia TTLL8 33 34
  • 80.87 (n)
cow
(Bos Taurus)
Mammalia TTLL8 33 34
  • 77.79 (n)
mouse
(Mus musculus)
Mammalia Ttll8 33 16 34
  • 73.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTLL8 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL8 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL8 34
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TTLL3A 34
  • 24 (a)
ManyToMany
TTLL3B 34
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for TTLL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTLL8 Gene

ENSEMBL:
Gene Tree for TTLL8 (if available)
TreeFam:
Gene Tree for TTLL8 (if available)

Paralogs for TTLL8 Gene

(1) SIMAP similar genes for TTLL8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTLL8: view

Variants for TTLL8 Gene

Sequence variations from dbSNP and Humsavar for TTLL8 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs11703598 likely-benign, Megalencephalic leukoencephalopathy with subcortical cysts 50,059,747(-) C/T upstream_transcript_variant
rs144067372 uncertain-significance, Megalencephalic leukoencephalopathy with subcortical cysts 50,060,084(-) G/A upstream_transcript_variant
rs145385166 likely-benign, Megalencephalic leukoencephalopathy with subcortical cysts 50,059,602(-) CCCC/CCC/CCCCC upstream_transcript_variant
rs200990035 likely-benign, Megalencephalic leukoencephalopathy with subcortical cysts 50,060,215(-) TT/TTT upstream_transcript_variant
rs35730155 likely-benign, Megalencephalic leukoencephalopathy with subcortical cysts 50,059,960(-) C/A/T upstream_transcript_variant

Variation tolerance for TTLL8 Gene

Gene Damage Index Score: 11.66; 93.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTLL8 Gene

Disorders for TTLL8 Gene

Additional Disease Information for TTLL8

No disorders were found for TTLL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL8 Gene

Publications for TTLL8 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3 58
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 58

Products for TTLL8 Gene

Sources for TTLL8 Gene

Content
Loading form....