Aliases for TTLL8 Gene

Aliases for TTLL8 Gene

  • Tubulin Tyrosine Ligase Like 8 2 3 5
  • Tubulin--Tyrosine Ligase-Like Protein 8 3 4
  • Protein Monoglycylase TTLL8 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 8 3
  • Tubulin Tyrosine Ligase-Like Family Member 8 2
  • EC 6.3.2.- 4

External Ids for TTLL8 Gene

Previous GeneCards Identifiers for TTLL8 Gene

  • GC22M048795
  • GC22M050453
  • GC22M033351

Summaries for TTLL8 Gene

GeneCards Summary for TTLL8 Gene

TTLL8 (Tubulin Tyrosine Ligase Like 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-glycine ligase activity and sigma factor antagonist activity. An important paralog of this gene is TTLL3.

UniProtKB/Swiss-Prot Summary for TTLL8 Gene

  • Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).

Additional gene information for TTLL8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTLL8 Gene

Genomics for TTLL8 Gene

GeneHancer (GH) Regulatory Elements for TTLL8 Gene

Promoters and enhancers for TTLL8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J050056 Enhancer 0.8 ENCODE CraniofacialAtlas 500.7 -0.3 -340 1.4 CTCF ZNF316 NFIC SP2 MAFF MAFK MAFG SIN3A GLIS1 RAD21 TTLL8 MOV10L1 SELENOO lnc-TTLL8-1 MLC1
GH22J050030 Enhancer 0.8 ENCODE 0.3 +28.7 28685 0.2 HNRNPK CTCF MYC NRF1 USF1 ZBTB10 ZBTB26 REST CTBP1 RAD21 lnc-MOV10L1-1 MOV10L1 lnc-MLC1-1 TTLL8
GH22J050017 Enhancer 0.8 ENCODE 0.3 +41.9 41945 0.2 SP1 RELA POLR2A BCL11A TCF12 USF2 FOS TARDBP MEF2B NBN HSALNG0136252 PIM3 MLC1 lnc-MOV10L1-1 TTLL8
GH22J050027 Enhancer 0.6 ENCODE 0.3 +31.1 31075 0.8 ZFX CLOCK MXI1 SIN3A HES1 MYC ELF1 GATA3 MAX NFIB lnc-MOV10L1-1 ENSG00000273253 HSALNG0136252 TTLL8
GH22J050032 Enhancer 0.5 Ensembl 0.4 +24.6 24631 2.2 TCF12 BATF EZH2 EBF1 PAX5 BHLHE40 EGR2 RUNX3 ARSA lnc-MOV10L1-1 lnc-MLC1-1 TTLL8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTLL8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTLL8

Top Transcription factor binding sites by QIAGEN in the TTLL8 gene promoter:
  • c-Myc
  • Cdc5
  • En-1
  • HNF-1
  • HNF-1A
  • Max
  • Max1
  • p53
  • PPAR-gamma2

Genomic Locations for TTLL8 Gene

Genomic Locations for TTLL8 Gene
chr22:50,015,123-50,059,132
(GRCh38/hg38)
Size:
44,010 bases
Orientation:
Minus strand
chr22:50,453,552-50,495,364
(GRCh37/hg19)
Size:
41,813 bases
Orientation:
Minus strand

Genomic View for TTLL8 Gene

Genes around TTLL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL8 Gene

Proteins for TTLL8 Gene

  • Protein details for TTLL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6PVC2-TTLL8_HUMAN
    Recommended name:
    Protein monoglycylase TTLL8
    Protein Accession:
    A6PVC2
    Secondary Accessions:
    • B5MDV0

    Protein attributes for TTLL8 Gene

    Size:
    850 amino acids
    Molecular mass:
    94676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL8 Gene

Post-translational modifications for TTLL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL8 Gene

Domains & Families for TTLL8 Gene

Gene Families for TTLL8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL8 Gene

GenScript: Design optimal peptide antigens:
  • Tubulin--tyrosine ligase-like protein 8 (TTLL8_HUMAN)
genes like me logo Genes that share domains with TTLL8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTLL8 Gene

Function for TTLL8 Gene

Molecular function for TTLL8 Gene

UniProtKB/Swiss-Prot Function:
Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).

Enzyme Numbers (IUBMB) for TTLL8 Gene

Phenotypes From GWAS Catalog for TTLL8 Gene

Gene Ontology (GO) - Molecular Function for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0070735 protein-glycine ligase activity ISS --
GO:0070736 protein-glycine ligase activity, initiating ISS --
genes like me logo Genes that share ontologies with TTLL8: view
genes like me logo Genes that share phenotypes with TTLL8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TTLL8

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTLL8 Gene

Localization for TTLL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL8 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL8 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 1
nucleus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
genes like me logo Genes that share ontologies with TTLL8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TTLL8 Gene

Pathways & Interactions for TTLL8 Gene

PathCards logo

SuperPathways for TTLL8 Gene

No Data Available

Interacting Proteins for TTLL8 Gene

;

Gene Ontology (GO) - Biological Process for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation TAS --
GO:0060271 cilium assembly IEA --
genes like me logo Genes that share ontologies with TTLL8: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL8 Gene

Drugs & Compounds for TTLL8 Gene

No Compound Related Data Available

Transcripts for TTLL8 Gene

mRNA/cDNA for TTLL8 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL8 Gene

No ASD Table

Relevant External Links for TTLL8 Gene

GeneLoc Exon Structure for
TTLL8

Expression for TTLL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTLL8 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL8 Gene

This gene is overexpressed in Testis (x50.8).

Protein differential expression in normal tissues from HIPED for TTLL8 Gene

This gene is overexpressed in Pancreatic juice (54.4) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL8 Gene



Protein tissue co-expression partners for TTLL8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTLL8

genes like me logo Genes that share expression patterns with TTLL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL8 Gene

Orthologs for TTLL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL8 30
  • 94.55 (n)
dog
(Canis familiaris)
Mammalia TTLL8 31 30
  • 80.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL8 31 30
  • 77.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll8 17 31 30
  • 73.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTLL8 31
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL8 31
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL8 31
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TTLL3A 31
  • 24 (a)
ManyToMany
TTLL3B 31
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 31
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for TTLL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTLL8 Gene

ENSEMBL:
Gene Tree for TTLL8 (if available)
TreeFam:
Gene Tree for TTLL8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTLL8: view image

Paralogs for TTLL8 Gene

(1) SIMAP similar genes for TTLL8 Gene using alignment to 3 proteins:

  • TTLL8_HUMAN
  • B5MDV0_HUMAN
  • J3KQ54_HUMAN
genes like me logo Genes that share paralogs with TTLL8: view

Variants for TTLL8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTLL8 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs17013076 - p.Arg191His
rs59727397 - p.Leu127Trp
rs9628315 - p.Glu294Lys

Additional dbSNP identifiers (rs#s) for TTLL8 Gene

Variation tolerance for TTLL8 Gene

Gene Damage Index Score: 11.66; 93.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTLL8 Gene

Disorders for TTLL8 Gene

Additional Disease Information for TTLL8

No disorders were found for TTLL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL8 Gene

Publications for TTLL8 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3 54
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 54

Products for TTLL8 Gene

Sources for TTLL8 Gene