Aliases for TTLL8 Gene
External Ids for TTLL8 Gene
Previous GeneCards Identifiers for TTLL8 Gene
GeneCards Summary for TTLL8 Gene
TTLL8 (Tubulin Tyrosine Ligase Like 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-glycine ligase activity and sigma factor antagonist activity. An important paralog of this gene is TTLL3.
UniProtKB/Swiss-Prot Summary for TTLL8 Gene
Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).