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Aliases for TTLL7 Gene
Aliases for TTLL7 Gene
External Ids for TTLL7 Gene
- HGNC: 26242
- Entrez Gene: 79739
- Ensembl: ENSG00000137941
- OMIM: 618813
- UniProtKB: Q6ZT98
Previous GeneCards Identifiers for TTLL7 Gene
- GC01M084048
- GC01M084330
- GC01M082451
Summaries for TTLL7 Gene
GeneCards Summary for TTLL7 Gene
TTLL7 (Tubulin Tyrosine Ligase Like 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TTLL6.
UniProtKB/Swiss-Prot Summary for TTLL7 Gene
-
Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).
Additional gene information for TTLL7 Gene
- HGNC(26242)
- Entrez Gene(79739)
- Ensembl(ENSG00000137941)
- OMIM(618813)
- UniProtKB(Q6ZT98)
- Open Targets Platform(ENSG00000137941)
- Search for TTLL7 at DataMed
- Search for TTLL7 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTLL7 Gene
Genomics for TTLL7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TTLL7 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J083997 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 608 | +0.1 | 149 | 2.4 | PRDM10 ZNF629 RFX1 SIX5 ZNF692 JUND PRDM1 ZIC2 ZNF776 POLR2A | TTLL7 lnc-TTLL7-1 piR-61818 | |
| GH01J083953 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 600.3 | +46.8 | 46828 | 0.1 | lnc-GNG5-6 TTLL7 TTLL7-IT1 | ||
| GH01J084102 | Enhancer | 1.1 | Ensembl ENCODE | 11.6 | -104.5 | -104539 | 2.6 | ATF7 PRDM10 ZNF629 LEF1 ZNF692 JUND PRDM1 MTA2 PKNOX1 RXRB | TTLL7 RPF1 hsa-miR-1273e-005 lnc-SAMD13-2 PRKACB SAMD13 | |
| GH01J083956 | Enhancer | 0.6 | dbSUPER | 18.8 | +36.5 | 36480 | 12.5 | CEBPG ATF7 PRDM1 CEBPB NFE2 CREB1 ATF2 MAFG ATF4 JUND | TTLL7 lnc-GNG5-6 TTLL7-IT1 | |
| GH01J083860 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE CraniofacialAtlas | 5.9 | +138.3 | 138327 | 1.6 | CTCF ZNF692 RFX1 PKNOX1 REST ZNF341 MGA ZFX ZBTB20 GATAD2B | LINC01725 LOC101927560 LOC107985041 TTLL7 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TTLL7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTLL7
- Top Transcription factor binding sites by QIAGEN in the TTLL7 gene promoter:
-
- FOXF2
- NF-AT
- NF-AT1
- NF-AT2
- POU2F1
- POU2F1a
- POU2F2
- POU2F2B
- POU2F2C
- STAT3
Genomic Locations for TTLL7 Gene
Genomic Locations for TTLL7 Gene
- chr1:83,865,021-83,999,150
- (GRCh38/hg38)
- Size:
- 134,130 bases
- Orientation:
- Minus strand
- chr1:84,330,711-84,464,833
- (GRCh37/hg19)
- Size:
- 134,123 bases
- Orientation:
- Minus strand
Genomic View for TTLL7 Gene
Genes around TTLL7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by HGNC
- 1p31.1 by Entrez Gene
- 1p31.1 by Ensembl
TTLL7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TTLL7 Gene
Proteins for TTLL7 Gene
-
Protein details for TTLL7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZT98-TTLL7_HUMAN
- Recommended name:
- Tubulin polyglutamylase TTLL7
- Protein Accession:
- Q6ZT98
- Q5TAX8
- Q5TAX9
- Q6P990
- Q86YS1
- Q9H5U4
Protein attributes for TTLL7 Gene
- Size:
- 887 amino acids
- Molecular mass:
- 102999 Da
- Quaternary structure:
-
- Interacts with both alpha- and beta-tubulin (via C-terminal tubulin tails).
Protein Expression for TTLL7 Gene
Post-translational modifications for TTLL7 Gene
Other Protein References for TTLL7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-TTLL7 monoclonal antibody
- Novus Biologicals Antibodies for TTLL7
- Invitrogen Antibodies for TTLL7 (AFLGC-TTLL7)
- antibodies-online: Show 5 available TTLL7 Antibodies ranked by validation data
- Compare Top TTLL7 Antibodies
-
Quality Products:
Protein Products
-
OriGene Purified Proteins for TTLL7
- Search Origene for MassSpec and Protein Over-expression Lysates for TTLL7
- Origene Custom Protein Services for TTLL7
- Novus Biologicals proteins for TTLL7
No data available for DME Specific Peptides for TTLL7 Gene
Domains & Families for TTLL7 Gene
Gene Families for TTLL7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TTLL7 Gene
- InterPro:
- Blocks:
-
- Tubulin-tyrosine ligase
- ProtoNet:
Suggested Antigen Peptide Sequences for TTLL7 Gene
- GenScript: Design optimal peptide antigens:
-
- TTLL7 protein (Q8TC09_HUMAN)
- Tubulin--tyrosine ligase-like protein 7 (TTLL7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6ZT98UniProtKB/Swiss-Prot:
TTLL7_HUMAN :- The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
- Belongs to the tubulin--tyrosine ligase family.
- Domain:
-
- The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
- Family:
-
- Belongs to the tubulin--tyrosine ligase family.
Function for TTLL7 Gene
Molecular function for TTLL7 Gene
- UniProtKB/Swiss-Prot Function:
- Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).
Enzyme Numbers (IUBMB) for TTLL7 Gene
Phenotypes From GWAS Catalog for TTLL7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0015631 | tubulin binding | IBA | 21873635 |
| GO:0016874 | ligase activity | IEA | -- |
| GO:0043014 | alpha-tubulin binding | IDA | 25959773 |
Phenotypes for TTLL7 Gene
- MGI mutant phenotypes for TTLL7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TTLL7:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TTLL7 - Select products 50% OFF >
- * TTLL7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for TTLL7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TTLL7
-
Santa Cruz Biotechnology (SCBT) CRISPR for TTLL7
miRNA for TTLL7 Gene
- miRTarBase miRNAs that target TTLL7
-
- hsa-miR-92a-3p (MIRT049432)
- hsa-miR-24-3p (MIRT447760)
- hsa-miR-135b-5p (MIRT447761)
- hsa-miR-135a-5p (MIRT447762)
- hsa-miR-4662b (MIRT447763)
- hsa-miR-4647 (MIRT447764)
- hsa-miR-4426 (MIRT447765)
- hsa-miR-548e-5p (MIRT447766)
- mmu-miR-1192 (MIRT580185)
- mmu-miR-495-3p (MIRT580186)
- mmu-miR-466b-3p (MIRT580187)
- mmu-miR-466c-3p (MIRT580188)
- mmu-miR-466p-3p (MIRT580189)
- mmu-miR-1903 (MIRT580190)
- mmu-miR-374b-5p (MIRT580191)
- mmu-miR-369-3p (MIRT580192)
- hsa-miR-574-5p (MIRT627328)
- hsa-miR-4455 (MIRT627329)
- hsa-miR-4652-3p (MIRT627330)
- hsa-miR-4743-3p (MIRT627331)
- hsa-miR-147a (MIRT627332)
- hsa-miR-6818-5p (MIRT627333)
- hsa-miR-6867-5p (MIRT627334)
- hsa-miR-1294 (MIRT627335)
- hsa-miR-4316 (MIRT627336)
- hsa-miR-4679 (MIRT627337)
- hsa-miR-4677-3p (MIRT627338)
- hsa-miR-136-3p (MIRT649932)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TTLL7
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL7
Clone Products
- Applied Biological Materials (abm): Clones for TTLL7 - Select products 50% OFF >
- * TTLL7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TTLL7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TTLL7
Cell Line Products
-
Horizon Cell Lines for TTLL7
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL7 Gene
Localization for TTLL7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TTLL7 Gene
- Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, dendrite. Perikaryon. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000250 UniProtKB:A4Q9F0}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| cytosol | 4 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA | -- |
| GO:0005929 | cilium | IEA,IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TTLL7 Gene
Pathways & Interactions for TTLL7 Gene
Interacting Proteins for TTLL7 Gene
Selected Interacting proteins:
Q6ZT98-TTLL7_HUMAN
ENSP00000260505
for TTLL7 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TTLL7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
| GO:0006464 | cellular protein modification process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0018095 | protein polyglutamylation | IDA,TAS | -- |
No data available for Pathways by source and SIGNOR curated interactions for TTLL7 Gene
Transcripts for TTLL7 Gene
mRNA/cDNA for TTLL7 Gene
- 3 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260505 7980 nts (view in UCSC)
- ENST00000464289 528 nts (view in UCSC)
- ENST00000467670 757 nts (view in UCSC)
- ENST00000472688 7969 nts (view in UCSC)
- ENST00000472937 640 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TTLL7 - Select products 50% OFF >
- * TTLL7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TTLL7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TTLL7
-
Santa Cruz Biotechnology (SCBT) CRISPR for TTLL7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TTLL7
- Browse OriGene Inhibitory RNA Products For TTLL7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL7
Clone Products
- Applied Biological Materials (abm): Clones for TTLL7 - Select products 50% OFF >
- * TTLL7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TTLL7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TTLL7
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: |
Relevant External Links for TTLL7 Gene
- GeneLoc Exon Structure for
- TTLL7
Expression for TTLL7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
This gene is overexpressed in Frontal cortex (49.5) and Rectum (19.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL7 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTLL7
SOURCE GeneReport for Unigene cluster for TTLL7 Gene:
Hs.445826mRNA Expression by UniProt/SwissProt for TTLL7 Gene:
Q6ZT98-TTLL7_HUMAN
Tissue specificity:
Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum.
Evidence on tissue expression from TISSUES for TTLL7 Gene
- Nervous system(4.6)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for TTLL7
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL7 Gene
Orthologs for TTLL7 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TTLL7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TTLL7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TTLL7 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ttll7 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TTLL7 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ttll7 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TTLL7 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TTLL7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TTLL7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ttll7 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ttll7 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for TTLL7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TTLL7 Gene
- ENSEMBL:
- Gene Tree for TTLL7 (if available)
- TreeFam:
- Gene Tree for TTLL7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TTLL7: view image
Paralogs for TTLL7 Gene
Paralogs for TTLL7 Gene
(3) SIMAP similar genes for TTLL7 Gene using alignment to 5 proteins:
- TTLL7_HUMAN
- F2Z2J7_HUMAN
- F2Z2X2_HUMAN
- I6L9D0_HUMAN
- Q8TC09_HUMAN
Variants for TTLL7 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1339682 | CNV | insertion | 17803354 |
| esv1612380 | CNV | deletion | 17803354 |
| esv26427 | CNV | loss | 19812545 |
| esv2664430 | CNV | deletion | 23128226 |
| esv2714218 | CNV | deletion | 23290073 |
| esv2714229 | CNV | deletion | 23290073 |
| esv3565137 | CNV | deletion | 23714750 |
| esv3586656 | CNV | loss | 21293372 |
| nsv1119700 | CNV | deletion | 24896259 |
| nsv1129131 | CNV | insertion | 24896259 |
| nsv1129464 | CNV | tandem duplication | 24896259 |
| nsv1137269 | CNV | deletion | 24896259 |
| nsv1147389 | CNV | insertion | 26484159 |
| nsv823353 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.85;
34.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TTLL7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TTLL7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTLL7 Gene
Disorders for TTLL7 Gene
Additional Disease Information for TTLL7
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for TTLL7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL7 Gene
Publications for TTLL7 Gene
- Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. (PMID: 25959773) Garnham CP … Roll-Mecak A (Cell 2015) 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for TTLL7 Gene
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- Custom Antibody Services
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- Custom Assay Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for TTLL7
- Origene Custom Protein Services for TTLL7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TTLL7
- Browse OriGene Inhibitory RNA Products For TTLL7
- OriGene qPCR primer pairs for TTLL7
- OriGene CRISPR knockouts for TTLL7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TTLL7
- Sino Biological Human cDNA Clone for TTLL7
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- Novus Biologicals Antibodies for TTLL7
- Novus Biologicals proteins for TTLL7
- Browse Antibodies
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- Browse ELISA Kits
- Invitrogen Antibodies for TTLL7 (AFLGC-TTLL7)
- VectorBuilder Custom and pre-made DNA vectors for TTLL7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TTLL7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TTLL7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TTLL7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TTLL7
- antibodies-online: Show 5 available TTLL7 Antibodies ranked by validation data
- Compare Top TTLL7 Antibodies
- Quality Products:
- antibodies-online: Search results for available TTLL7 related products ranked by validation data
- antibodies-online: Search results for available TTLL7 related products ranked by validation data
- Horizon Cell Lines for TTLL7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TTLL7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TTLL7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TTLL7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL7
Sources for TTLL7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB