Aliases for TTLL7 Gene

Aliases for TTLL7 Gene

  • Tubulin Tyrosine Ligase Like 7 2 3 5
  • Tubulin--Tyrosine Ligase-Like Protein 7 3 4
  • Testis Development Protein NYD-SP30 3 4
  • Tubulin Polyglutamylase TTLL7 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 7 3
  • Tubulin Tyrosine Ligase-Like Family Member 7 2
  • EC 6.-.-.- 4
  • FLJ23033 2
  • TTLL7 5

External Ids for TTLL7 Gene

Previous GeneCards Identifiers for TTLL7 Gene

  • GC01M084048
  • GC01M084330
  • GC01M082451

Summaries for TTLL7 Gene

GeneCards Summary for TTLL7 Gene

TTLL7 (Tubulin Tyrosine Ligase Like 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TTLL6.

UniProtKB/Swiss-Prot Summary for TTLL7 Gene

  • Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).

Additional gene information for TTLL7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTLL7 Gene

Genomics for TTLL7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTLL7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J083997 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 608 +0.1 149 2.4 PRDM10 ZNF629 RFX1 SIX5 ZNF692 JUND PRDM1 ZIC2 ZNF776 POLR2A TTLL7 lnc-TTLL7-1 piR-61818
GH01J083953 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.3 +46.8 46828 0.1 lnc-GNG5-6 TTLL7 TTLL7-IT1
GH01J084102 Enhancer 1.1 Ensembl ENCODE 11.6 -104.5 -104539 2.6 ATF7 PRDM10 ZNF629 LEF1 ZNF692 JUND PRDM1 MTA2 PKNOX1 RXRB TTLL7 RPF1 hsa-miR-1273e-005 lnc-SAMD13-2 PRKACB SAMD13
GH01J083956 Enhancer 0.6 dbSUPER 18.8 +36.5 36480 12.5 CEBPG ATF7 PRDM1 CEBPB NFE2 CREB1 ATF2 MAFG ATF4 JUND TTLL7 lnc-GNG5-6 TTLL7-IT1
GH01J083860 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 5.9 +138.3 138327 1.6 CTCF ZNF692 RFX1 PKNOX1 REST ZNF341 MGA ZFX ZBTB20 GATAD2B LINC01725 LOC101927560 LOC107985041 TTLL7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTLL7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTLL7

Top Transcription factor binding sites by QIAGEN in the TTLL7 gene promoter:
  • FOXF2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2B
  • POU2F2C
  • STAT3

Genomic Locations for TTLL7 Gene

Genomic Locations for TTLL7 Gene
chr1:83,865,021-83,999,150
(GRCh38/hg38)
Size:
134,130 bases
Orientation:
Minus strand
chr1:84,330,711-84,464,833
(GRCh37/hg19)
Size:
134,123 bases
Orientation:
Minus strand

Genomic View for TTLL7 Gene

Genes around TTLL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL7 Gene

Proteins for TTLL7 Gene

  • Protein details for TTLL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZT98-TTLL7_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL7
    Protein Accession:
    Q6ZT98
    Secondary Accessions:
    • Q5TAX8
    • Q5TAX9
    • Q6P990
    • Q86YS1
    • Q9H5U4

    Protein attributes for TTLL7 Gene

    Size:
    887 amino acids
    Molecular mass:
    102999 Da
    Quaternary structure:
    • Interacts with both alpha- and beta-tubulin (via C-terminal tubulin tails).

    Three dimensional structures from OCA and Proteopedia for TTLL7 Gene

    Alternative splice isoforms for TTLL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL7 Gene

Post-translational modifications for TTLL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL7 Gene

Domains & Families for TTLL7 Gene

Gene Families for TTLL7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL7 Gene

InterPro:
Blocks:
  • Tubulin-tyrosine ligase
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL7 Gene

GenScript: Design optimal peptide antigens:
  • TTLL7 protein (Q8TC09_HUMAN)
  • Tubulin--tyrosine ligase-like protein 7 (TTLL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZT98

UniProtKB/Swiss-Prot:

TTLL7_HUMAN :
  • The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL7: view

Function for TTLL7 Gene

Molecular function for TTLL7 Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).

Enzyme Numbers (IUBMB) for TTLL7 Gene

Phenotypes From GWAS Catalog for TTLL7 Gene

Gene Ontology (GO) - Molecular Function for TTLL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0015631 tubulin binding IBA 21873635
GO:0016874 ligase activity IEA --
GO:0043014 alpha-tubulin binding IDA 25959773
genes like me logo Genes that share ontologies with TTLL7: view
genes like me logo Genes that share phenotypes with TTLL7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL7 Gene

Localization for TTLL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL7 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, dendrite. Perikaryon. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000250 UniProtKB:A4Q9F0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL7 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TTLL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA,IBA 21873635
genes like me logo Genes that share ontologies with TTLL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TTLL7 Gene

Pathways & Interactions for TTLL7 Gene

PathCards logo

SuperPathways for TTLL7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0006464 cellular protein modification process IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0018095 protein polyglutamylation IDA,TAS --
genes like me logo Genes that share ontologies with TTLL7: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL7 Gene

Drugs & Compounds for TTLL7 Gene

No Compound Related Data Available

Transcripts for TTLL7 Gene

mRNA/cDNA for TTLL7 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL7

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TTLL7 Gene

GeneLoc Exon Structure for
TTLL7

Expression for TTLL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTLL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for TTLL7 Gene

This gene is overexpressed in Frontal cortex (49.5) and Rectum (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL7 Gene



Protein tissue co-expression partners for TTLL7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTLL7

SOURCE GeneReport for Unigene cluster for TTLL7 Gene:

Hs.445826

mRNA Expression by UniProt/SwissProt for TTLL7 Gene:

Q6ZT98-TTLL7_HUMAN
Tissue specificity: Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum.

Evidence on tissue expression from TISSUES for TTLL7 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TTLL7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL7 Gene

Orthologs for TTLL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTLL7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTLL7 30 31
  • 99.66 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTLL7 30 31
  • 93.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TTLL7 30 31
  • 92.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttll7 30 17 31
  • 84.78 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTLL7 31
  • 82 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttll7 30
  • 81.89 (n)
Oppossum
(Monodelphis domestica)
Mammalia TTLL7 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TTLL7 30 31
  • 74.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTLL7 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttll7 30
  • 72.56 (n)
Zebrafish
(Danio rerio)
Actinopterygii ttll7 30 31
  • 70.53 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToOne
Species where no ortholog for TTLL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTLL7 Gene

ENSEMBL:
Gene Tree for TTLL7 (if available)
TreeFam:
Gene Tree for TTLL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTLL7: view image

Paralogs for TTLL7 Gene

(3) SIMAP similar genes for TTLL7 Gene using alignment to 5 proteins:

  • TTLL7_HUMAN
  • F2Z2J7_HUMAN
  • F2Z2X2_HUMAN
  • I6L9D0_HUMAN
  • Q8TC09_HUMAN
genes like me logo Genes that share paralogs with TTLL7: view

Variants for TTLL7 Gene

Additional dbSNP identifiers (rs#s) for TTLL7 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTLL7 Gene

Variant ID Type Subtype PubMed ID
esv1339682 CNV insertion 17803354
esv1612380 CNV deletion 17803354
esv26427 CNV loss 19812545
esv2664430 CNV deletion 23128226
esv2714218 CNV deletion 23290073
esv2714229 CNV deletion 23290073
esv3565137 CNV deletion 23714750
esv3586656 CNV loss 21293372
nsv1119700 CNV deletion 24896259
nsv1129131 CNV insertion 24896259
nsv1129464 CNV tandem duplication 24896259
nsv1137269 CNV deletion 24896259
nsv1147389 CNV insertion 26484159
nsv823353 CNV loss 20364138

Variation tolerance for TTLL7 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTLL7 Gene

Disorders for TTLL7 Gene

Additional Disease Information for TTLL7

No disorders were found for TTLL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL7 Gene

Publications for TTLL7 Gene

  1. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. (PMID: 25959773) Garnham CP … Roll-Mecak A (Cell 2015) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TTLL7 Gene

Sources for TTLL7 Gene