Aliases for TTLL6 Gene
External Ids for TTLL6 Gene
Previous GeneCards Identifiers for TTLL6 Gene
GeneCards Summary for TTLL6 Gene
TTLL6 (Tubulin Tyrosine Ligase Like 6) is a Protein Coding gene. Diseases associated with TTLL6 include Joubert Syndrome 33 and Joubert Syndrome 15. Gene Ontology (GO) annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL13P.
UniProtKB/Swiss-Prot Summary for TTLL6 Gene
Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS.