Aliases for TTLL5 Gene
External Ids for TTLL5 Gene
Previous HGNC Symbols for TTLL5 Gene
Previous GeneCards Identifiers for TTLL5 Gene
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
GeneCards Summary for TTLL5 Gene
TTLL5 (Tubulin Tyrosine Ligase Like 5) is a Protein Coding gene. Diseases associated with TTLL5 include Cone-Rod Dystrophy 19 and Cone-Rod Dystrophy 2. Gene Ontology (GO) annotations related to this gene include ligase activity.
UniProtKB/Swiss-Prot Summary for TTLL5 Gene
Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691).