Aliases for TTLL4 Gene
External Ids for TTLL4 Gene
Previous GeneCards Identifiers for TTLL4 Gene
GeneCards Summary for TTLL4 Gene
TTLL4 (Tubulin Tyrosine Ligase Like 4) is a Protein Coding gene. Diseases associated with TTLL4 include Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease and Fundus Dystrophy. Gene Ontology (GO) annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL6.
UniProtKB/Swiss-Prot Summary for TTLL4 Gene
Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS, leading to impair the nucleotidyltransferase activity of CGAS.