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Aliases for TTLL4 Gene

Aliases for TTLL4 Gene

  • Tubulin Tyrosine Ligase Like 4 2 3 5
  • Tubulin Tyrosine Ligase-Like Family Member 4 2
  • Tubulin--Tyrosine Ligase-Like Protein 4 4
  • EC 6.-.-.- 4
  • KIAA0173 4

External Ids for TTLL4 Gene

Previous GeneCards Identifiers for TTLL4 Gene

  • GC02P219779
  • GC02P219401
  • GC02P219283
  • GC02P219575
  • GC02P211428

Summaries for TTLL4 Gene

GeneCards Summary for TTLL4 Gene

TTLL4 (Tubulin Tyrosine Ligase Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL5.

UniProtKB/Swiss-Prot for TTLL4 Gene

  • Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1.

Additional gene information for TTLL4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL4 Gene

Genomics for TTLL4 Gene

GeneHancer (GH) Regulatory Elements for TTLL4 Gene

Promoters and enhancers for TTLL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I218710 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 558.8 +0.4 377 2.4 HDGF PKNOX1 FOXA2 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 TTLL4 AAMP ANKZF1 CNOT9 NHEJ1 SLC23A3 USP37 STK36 ENSG00000272644 GMPPA
GH02I218781 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 16.3 +72.8 72778 6 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 FOS RXRA CYP27A1 PLCD4 TTLL4 PRKAG3 PNKD SLC11A1 RNF25 TMBIM1 ENSG00000272555
GH02I218743 Enhancer 1.4 Ensembl ENCODE dbSUPER 15.7 +34.2 34249 3.6 HDGF PKNOX1 ATF1 ARNT ARID4B DMAP1 IRF4 ATF7 RUNX3 RXRA CYP27A1 PLCD4 TTLL4 PRKAG3 RNF25 STK36 GC02P218766
GH02I218805 Enhancer 1.4 Ensembl ENCODE dbSUPER 14 +95.5 95450 2.3 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF48 YY1 ZNF213 ATF7 TTLL4 CYP27A1 ZNF142 ENSG00000272555
GH02I218393 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 -309.8 -309828 14.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 CTDSP1 GC02P218403 ENSG00000273361 MIR26B CNOT9 AAMP USP37 STK36 ANKZF1 BCS1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTLL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTLL4 gene promoter:

Genomic Locations for TTLL4 Gene

Genomic Locations for TTLL4 Gene
chr2:218,710,835-218,755,416
(GRCh38/hg38)
Size:
44,582 bases
Orientation:
Plus strand
chr2:219,575,568-219,620,139
(GRCh37/hg19)

Genomic View for TTLL4 Gene

Genes around TTLL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL4 Gene

Proteins for TTLL4 Gene

  • Protein details for TTLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14679-TTLL4_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL4
    Protein Accession:
    Q14679
    Secondary Accessions:
    • A8K6V5
    • Q8WW29

    Protein attributes for TTLL4 Gene

    Size:
    1199 amino acids
    Molecular mass:
    133378 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11490.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TTLL4 Gene

neXtProt entry for TTLL4 Gene

Post-translational modifications for TTLL4 Gene

No data available for DME Specific Peptides for TTLL4 Gene

Domains & Families for TTLL4 Gene

Gene Families for TTLL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL4 Gene

Suggested Antigen Peptide Sequences for TTLL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14679

UniProtKB/Swiss-Prot:

TTLL4_HUMAN :
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL4: view

Function for TTLL4 Gene

Molecular function for TTLL4 Gene

UniProtKB/Swiss-Prot Function:
Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1.

Enzyme Numbers (IUBMB) for TTLL4 Gene

Phenotypes From GWAS Catalog for TTLL4 Gene

Gene Ontology (GO) - Molecular Function for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0015631 tubulin binding ISS 21074048
GO:0016874 ligase activity IEA --
GO:0070739 protein-glutamic acid ligase activity ISS --
GO:0070740 tubulin-glutamic acid ligase activity TAS --
genes like me logo Genes that share ontologies with TTLL4: view
genes like me logo Genes that share phenotypes with TTLL4: view

Animal Models for TTLL4 Gene

MGI Knock Outs for TTLL4:

miRNA for TTLL4 Gene

miRTarBase miRNAs that target TTLL4

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTLL4 Gene

Localization for TTLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL4 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000250 UniProtKB:Q80UG8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL4 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TTLL4: view

Pathways & Interactions for TTLL4 Gene

SuperPathways for TTLL4 Gene

No Data Available

Interacting Proteins for TTLL4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258398%0d%0a9606.ENSP00000359240%0d%0a
Selected Interacting proteins: Q14679-TTLL4_HUMAN ENSP00000258398 for TTLL4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018095 protein polyglutamylation ISS,TAS --
GO:0018200 peptidyl-glutamic acid modification ISS --
genes like me logo Genes that share ontologies with TTLL4: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL4 Gene

Drugs & Compounds for TTLL4 Gene

No Compound Related Data Available

Transcripts for TTLL4 Gene

Unigene Clusters for TTLL4 Gene

Tubulin tyrosine ligase-like family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6:
SP7: - -
SP8: -
SP9: - - - -
SP10:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TTLL4 Gene

GeneLoc Exon Structure for
TTLL4
ECgene alternative splicing isoforms for
TTLL4

Expression for TTLL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL4 Gene

Protein differential expression in normal tissues from HIPED for TTLL4 Gene

This gene is overexpressed in Amniocyte (36.2), Cervix (26.2), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTLL4 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTLL4 Gene:

TTLL4

SOURCE GeneReport for Unigene cluster for TTLL4 Gene:

Hs.471405

Evidence on tissue expression from TISSUES for TTLL4 Gene

  • Bone marrow(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with TTLL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL4 Gene

Orthologs for TTLL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL4 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia TTLL4 34 33
  • 86.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL4 33 34
  • 86.07 (n)
mouse
(Mus musculus)
Mammalia Ttll4 33 16 34
  • 84.36 (n)
rat
(Rattus norvegicus)
Mammalia Ttll4 33
  • 84.21 (n)
oppossum
(Monodelphis domestica)
Mammalia TTLL4 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTLL4 33 34
  • 62.25 (n)
lizard
(Anolis carolinensis)
Reptilia TTLL4 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttll4 33
  • 57.01 (n)
Str.16925 33
zebrafish
(Danio rerio)
Actinopterygii ttll4 34
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3964 34
  • 34 (a)
OneToMany
CG16833 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ttll-4 34 33
  • 47.32 (n)
OneToOne
Species where no ortholog for TTLL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL4 Gene

ENSEMBL:
Gene Tree for TTLL4 (if available)
TreeFam:
Gene Tree for TTLL4 (if available)

Paralogs for TTLL4 Gene

genes like me logo Genes that share paralogs with TTLL4: view

Variants for TTLL4 Gene

Sequence variations from dbSNP and Humsavar for TTLL4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000142178 -- 218,712,547(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000152674 -- 218,736,302(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000167682 -- 218,752,078(+) T/A intron_variant
rs1000289072 -- 218,743,015(+) G/A intron_variant
rs1000298137 -- 218,744,839(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL4 Gene

Variant ID Type Subtype PubMed ID
esv3389959 CNV insertion 20981092
nsv518750 CNV loss 19592680

Variation tolerance for TTLL4 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.24; 96.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL4 Gene

Disorders for TTLL4 Gene

Additional Disease Information for TTLL4

No disorders were found for TTLL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL4 Gene

Publications for TTLL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V … De Sario A (Gene 2000) 2 3 58
  4. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TTLL4 Gene

Sources for TTLL4 Gene

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