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Aliases for TTLL2 Gene

Aliases for TTLL2 Gene

  • Tubulin Tyrosine Ligase Like 2 2 3 5
  • Tubulin--Tyrosine Ligase-Like Protein 2 3 4
  • Testis-Specific Protein NYD-TSPG 3 4
  • C6orf104 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 2 3
  • Tubulin Tyrosine Ligase-Like Family Member 2 2
  • Probable Tubulin Polyglutamylase TTLL2 3
  • Chromosome 6 Open Reading Frame 104 2
  • DJ366N23.3 3
  • EC 6.-.-.- 4
  • NYD-TSPG 3

External Ids for TTLL2 Gene

Previous HGNC Symbols for TTLL2 Gene

  • C6orf104

Previous GeneCards Identifiers for TTLL2 Gene

  • GC06P167647
  • GC06P167708
  • GC06P167658
  • GC06P167738
  • GC06P165211

Summaries for TTLL2 Gene

GeneCards Summary for TTLL2 Gene

TTLL2 (Tubulin Tyrosine Ligase Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot for TTLL2 Gene

  • Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

Additional gene information for TTLL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL2 Gene

Genomics for TTLL2 Gene

GeneHancer (GH) Regulatory Elements for TTLL2 Gene

Promoters and enhancers for TTLL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J167325 Promoter 0.5 EPDnew 650.7 +0.0 8 0.1 TTLL2 RPS6KA2-AS1 LOC100421518
GH06J167289 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 13 -33.3 -33281 3.8 ELF3 FOXA2 ARID4B DMAP1 ZNF48 RAD21 RARA YY1 ZNF614 CREM UNC93A LOC102724220 TTLL2 GC06P167312
GH06J167288 Enhancer 0.8 ENCODE dbSUPER 13 -35.8 -35794 0.7 ELF3 MEIS2 GATAD2A CTCF MXI1 ATF1 L3MBTL2 MXD4 RAD21 ZGPAT TTLL2 UNC93A GC06P167312
GH06J167349 Enhancer 1.1 Ensembl ENCODE 6 +25.6 25560 2.7 ARNT SIN3A ZNF2 YY1 GLIS2 ZNF143 ATF7 RUNX3 RXRA ZHX2 UNC93A LINC01558 TTLL2 TCP10 LOC100420305 LOC100421518 GC06M167354
GH06J167342 Enhancer 1 ENCODE 0.4 +17.2 17242 0.2 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 ATF7 UNC93A LOC100421518 TTLL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTLL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTLL2 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • RFX1
  • XBP-1
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • AREB6
  • POU2F1a
  • POU2F1

Genomic Locations for TTLL2 Gene

Genomic Locations for TTLL2 Gene
34,418 bases
Plus strand
34,418 bases
Plus strand

Genomic View for TTLL2 Gene

Genes around TTLL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL2 Gene

Proteins for TTLL2 Gene

  • Protein details for TTLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tubulin polyglutamylase TTLL2
    Protein Accession:
    Secondary Accessions:
    • B2RB11
    • B3KS77
    • Q7Z6R8
    • Q86X22

    Protein attributes for TTLL2 Gene

    592 amino acids
    Molecular mass:
    67336 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTLL2 Gene

Post-translational modifications for TTLL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL2 Gene

No data available for DME Specific Peptides for TTLL2 Gene

Domains & Families for TTLL2 Gene

Gene Families for TTLL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL2 Gene

Suggested Antigen Peptide Sequences for TTLL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tubulin--tyrosine ligase family.
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL2: view

Function for TTLL2 Gene

Molecular function for TTLL2 Gene

UniProtKB/Swiss-Prot Function:
Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

Enzyme Numbers (IUBMB) for TTLL2 Gene

Phenotypes From GWAS Catalog for TTLL2 Gene

Gene Ontology (GO) - Molecular Function for TTLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL2: view
genes like me logo Genes that share phenotypes with TTLL2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTLL2 Gene

Localization for TTLL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL2 gene
Compartment Confidence
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTLL2 Gene

Pathways & Interactions for TTLL2 Gene

SuperPathways for TTLL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL2: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL2 Gene

Drugs & Compounds for TTLL2 Gene

No Compound Related Data Available

Transcripts for TTLL2 Gene

mRNA/cDNA for TTLL2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTLL2 Gene

Tubulin tyrosine ligase-like family, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL2 Gene

No ASD Table

Relevant External Links for TTLL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL2 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL2 Gene

This gene is overexpressed in Testis (x35.7).

Protein differential expression in normal tissues from HIPED for TTLL2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL2 Gene

Protein tissue co-expression partners for TTLL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL2 Gene:


SOURCE GeneReport for Unigene cluster for TTLL2 Gene:


mRNA Expression by UniProt/SwissProt for TTLL2 Gene:

Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with TTLL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL2 Gene

Orthologs for TTLL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTLL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTLL2 34 33
  • 97.11 (n)
(Canis familiaris)
Mammalia TTLL2 34 33
  • 77.71 (n)
(Bos Taurus)
Mammalia TTLL2 34 33
  • 74.5 (n)
(Mus musculus)
Mammalia Ttll2 16 34 33
  • 71.59 (n)
(Rattus norvegicus)
Mammalia Ttll2 33
  • 70.94 (n)
(Monodelphis domestica)
Mammalia TTLL2 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 2 (a)
(Gallus gallus)
Aves TTLL2 34 33
  • 59.99 (n)
(Anolis carolinensis)
Reptilia TTLL2 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497970 33
  • 56.87 (n)
(Danio rerio)
Actinopterygii ttll2 34 33
  • 52.76 (n)
Species where no ortholog for TTLL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL2 Gene

Gene Tree for TTLL2 (if available)
Gene Tree for TTLL2 (if available)
Evolutionary constrained regions (ECRs) for TTLL2: view image

Paralogs for TTLL2 Gene

(1) SIMAP similar genes for TTLL2 Gene using alignment to 2 proteins:

  • D6R9R4_HUMAN
genes like me logo Genes that share paralogs with TTLL2: view

Variants for TTLL2 Gene

Sequence variations from dbSNP and Humsavar for TTLL2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000102585 -- 167,331,774(+) C/T intron_variant
rs1000620193 -- 167,335,633(+) A/C intron_variant
rs1000632454 -- 167,327,449(+) C/G intron_variant
rs1001158993 -- 167,331,019(+) G/C intron_variant
rs1001424110 -- 167,340,062(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL2 Gene

Variant ID Type Subtype PubMed ID
nsv949893 CNV deletion 24416366
nsv7389 OTHER inversion 18451855
nsv605345 CNV gain 21841781
nsv605344 CNV loss 21841781
nsv605338 CNV gain 21841781
nsv517210 CNV gain+loss 19592680
nsv470873 CNV gain 18288195
nsv464145 CNV loss 19166990
nsv464141 CNV gain 19166990
nsv1024654 CNV loss 25217958
nsv1022342 CNV loss 25217958
esv3611660 CNV gain 21293372
esv3611659 CNV loss 21293372
esv3611656 CNV loss 21293372
esv3611649 CNV gain 21293372
esv3576253 CNV gain 25503493
esv34252 CNV gain 17911159
esv33288 CNV loss 17666407
esv3282385 CNV deletion 24192839
esv2761058 CNV gain 21179565
esv2759492 CNV gain 17122850
esv2733230 CNV deletion 23290073
esv24545 CNV gain+loss 19812545
dgv6198n100 CNV gain 25217958
dgv6197n100 CNV loss 25217958
dgv6196n100 CNV gain 25217958
dgv6194n100 CNV gain 25217958
dgv3714e59 CNV duplication 20981092
dgv11056n54 CNV gain 21841781

Variation tolerance for TTLL2 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL2 Gene

Disorders for TTLL2 Gene

Additional Disease Information for TTLL2

No disorders were found for TTLL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL2 Gene

Publications for TTLL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V … De Sario A (Gene 2000) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G … Rudan I (PLoS genetics 2013) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TTLL2 Gene

Sources for TTLL2 Gene

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