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Aliases for TTLL13P Gene

Aliases for TTLL13P Gene

  • Tubulin Tyrosine Ligase Like 13, Pseudogene 2 3 5
  • Tubulin Tyrosine Ligase-Like Family Member 13, Pseudogene 2 3
  • Tubulin Tyrosine Ligase-Like Family, Member 13 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 13 3 4
  • TTLL13 3 4
  • Tubulin Tyrosine Ligase-Like Family Member 13 Pseudogene 4
  • Tubulin Polyglutamylase TTLL13 3
  • EC 6.-.-.- 4

External Ids for TTLL13P Gene

Previous HGNC Symbols for TTLL13P Gene

  • TTLL13

Summaries for TTLL13P Gene

GeneCards Summary for TTLL13P Gene

TTLL13P (Tubulin Tyrosine Ligase Like 13, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TTLL6.

UniProtKB/Swiss-Prot for TTLL13P Gene

  • Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

Additional gene information for TTLL13P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL13P Gene

Genomics for TTLL13P Gene

GeneHancer (GH) Regulatory Elements for TTLL13P Gene

Promoters and enhancers for TTLL13P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I090248 Promoter/Enhancer 1.5 Ensembl ENCODE 569.2 -0.1 -96 1.1 PKNOX1 ARID4B NEUROD1 SIN3A FEZF1 ZNF48 YY1 ZNF121 GLIS2 ATF7 TTLL13P ENSG00000261147 CIB1 ENSG00000228998 NIFKP5 ENSG00000270322 GC15P090245 ENSG00000284626
GH15I090263 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.3 +16.2 16219 3.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 CIB1 ENSG00000275674 NGRN ENSG00000228998 TTLL13P ARPIN RPL36AP43 NIFKP5 GDPGP1 GABARAPL3
GH15I090200 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 6 -47.6 -47566 3.9 HDGF SIN3A GLIS2 ATF7 SP3 SP5 SMARCB1 GLIS1 CTCF ZNF449 SEMA4B CIB1 ENSG00000228998 TTLL13P RPS12P26 GC15M090188
GH15I090157 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.8 -86.0 -85988 12.2 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 UNC45A CIB1 ENSG00000259314 POLG RCCD1 SEMA4B LOC100631255 RPL36AP43 GDPGP1 NGRN
GH15I090141 Enhancer 1.4 Ensembl ENCODE dbSUPER 7.6 -106.7 -106691 2.7 PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF2 ZNF766 ZNF143 KLF13 DEK GC15M090124 CIB1 UNC45A NGRN GDPGP1 POLG IDH2 TTLL13P SEMA4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTLL13P on UCSC Golden Path with GeneCards custom track

Genomic Locations for TTLL13P Gene

Genomic Locations for TTLL13P Gene
chr15:90,249,530-90,265,482
(GRCh38/hg38)
Size:
15,953 bases
Orientation:
Plus strand
chr15:90,792,762-90,808,199
(GRCh37/hg19)

Genomic View for TTLL13P Gene

Genes around TTLL13P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL13P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL13P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL13P Gene

Proteins for TTLL13P Gene

  • Protein details for TTLL13P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNM8-TTL13_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL13P
    Protein Accession:
    A6NNM8

    Protein attributes for TTLL13P Gene

    Size:
    815 amino acids
    Molecular mass:
    93645 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC036668; Type=Frameshift; Positions=298; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL13P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL13P Gene

Post-translational modifications for TTLL13P Gene

No Post-translational modifications

Other Protein References for TTLL13P Gene

No data available for DME Specific Peptides for TTLL13P Gene

Domains & Families for TTLL13P Gene

Gene Families for TTLL13P Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL13P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL13P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNM8

UniProtKB/Swiss-Prot:

TTL13_HUMAN :
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL13P: view

Function for TTLL13P Gene

Molecular function for TTLL13P Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

Enzyme Numbers (IUBMB) for TTLL13P Gene

Gene Ontology (GO) - Molecular Function for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0070740 tubulin-glutamic acid ligase activity TAS --
genes like me logo Genes that share ontologies with TTLL13P: view

Phenotypes for TTLL13P Gene

GenomeRNAi human phenotypes for TTLL13P:
genes like me logo Genes that share phenotypes with TTLL13P: view

miRNA for TTLL13P Gene

miRTarBase miRNAs that target TTLL13P

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL13P Gene

Localization for TTLL13P Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL13P gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TTLL13P Gene

Pathways & Interactions for TTLL13P Gene

SuperPathways for TTLL13P Gene

No Data Available

Interacting Proteins for TTLL13P Gene

Selected Interacting proteins: A6NNM8-TTL13_HUMAN for TTLL13P Gene via IID

Symbol External ID(s) Details
CSTF3

Gene Ontology (GO) - Biological Process for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018095 protein polyglutamylation TAS --
genes like me logo Genes that share ontologies with TTLL13P: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL13P Gene

Drugs & Compounds for TTLL13P Gene

No Compound Related Data Available

Transcripts for TTLL13P Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL13P Gene

No ASD Table

Relevant External Links for TTLL13P Gene

GeneLoc Exon Structure for
TTLL13P
ECgene alternative splicing isoforms for
TTLL13P

Expression for TTLL13P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL13P Gene

Protein differential expression in normal tissues from HIPED for TTLL13P Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL13P Gene



Protein tissue co-expression partners for TTLL13P Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL13P Gene:

TTLL13P
genes like me logo Genes that share expression patterns with TTLL13P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL13P Gene

Orthologs for TTLL13P Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL13P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 49 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ttll13 34
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5987 34
  • 29 (a)
ManyToMany
CG16716 34
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToMany
Species where no ortholog for TTLL13P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTLL13P Gene

ENSEMBL:
Gene Tree for TTLL13P (if available)
TreeFam:
Gene Tree for TTLL13P (if available)

Paralogs for TTLL13P Gene

genes like me logo Genes that share paralogs with TTLL13P: view

Variants for TTLL13P Gene

Sequence variations from dbSNP and Humsavar for TTLL13P Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000076592 -- 90,257,050(+) A/G intron_variant
rs1000258463 -- 90,250,306(+) G/A intron_variant
rs1000515748 -- 90,249,955(+) A/T intron_variant
rs1000551771 -- 90,250,252(+) C/T intron_variant
rs1000982471 -- 90,251,669(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL13P Gene

Variant ID Type Subtype PubMed ID
nsv94838 CNV deletion 16902084
nsv94314 CNV deletion 16902084
nsv833087 CNV loss 17160897
nsv1052652 CNV gain 25217958
esv3637218 CNV gain 21293372
esv3637217 CNV loss 21293372
esv3552835 CNV deletion 23714750
esv3194606 CNV deletion 24192839
esv2760054 CNV gain 17122850
esv2751541 CNV gain 17911159

Variation tolerance for TTLL13P Gene

Gene Damage Index Score: 18.97; 98.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL13P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL13P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL13P Gene

Disorders for TTLL13P Gene

Additional Disease Information for TTLL13P

No disorders were found for TTLL13P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL13P Gene

Publications for TTLL13P Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3 58
  2. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. (PMID: 25959773) Garnham CP … Roll-Mecak A (Cell 2015) 4 58
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TTLL13P Gene

Sources for TTLL13P Gene

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