Aliases for TTLL12 Gene
External Ids for TTLL12 Gene
Previous GeneCards Identifiers for TTLL12 Gene
GeneCards Summary for TTLL12 Gene
TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene. Diseases associated with TTLL12 include Acute Closed-Angle Glaucoma and Orofaciodigital Syndrome Viii. An important paralog of this gene is TTLL13P.
UniProtKB/Swiss-Prot Summary for TTLL12 Gene
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).