Aliases for TTLL10 Gene

Aliases for TTLL10 Gene

  • Tubulin Tyrosine Ligase Like 10 2 3 5
  • Tubulin Tyrosine Ligase-Like Family, Member 5 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 10 3 4
  • Inactive Polyglycylase TTLL10 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 10 3
  • Tubulin Tyrosine Ligase-Like Family Member 10 2
  • FLJ36119 2
  • TTLL10 5
  • TTLL5 3

External Ids for TTLL10 Gene

Previous HGNC Symbols for TTLL10 Gene

  • TTLL5

Previous GeneCards Identifiers for TTLL10 Gene

  • GC01P001156
  • GC01P000380
  • GC01P001140

Summaries for TTLL10 Gene

GeneCards Summary for TTLL10 Gene

TTLL10 (Tubulin Tyrosine Ligase Like 10) is a Protein Coding gene. Diseases associated with TTLL10 include Cone-Rod Dystrophy 16 and Cone-Rod Dystrophy 18. Gene Ontology (GO) annotations related to this gene include protein-glycine ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot Summary for TTLL10 Gene

Additional gene information for TTLL10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTLL10 Gene

Genomics for TTLL10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTLL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001172 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 600.7 +0.2 172 0.2 RFX1 RFX3 BMI1 SAP130 MYNN CTCF TTLL10 lnc-TTLL10-2 ANKRD65 ACAP3 TTLL10-AS1 TNFRSF18
GH01J001171 Enhancer 0.8 ENCODE dbSUPER 600.7 -1.6 -1629 0.7 IKZF2 EED DPF2 RELB GATAD2B CREB1 NBN IKZF1 NR2F1 POLR2A TTLL10 lnc-TTLL10-2 MIR429 ENSG00000272141 C1orf159
GH01J001179 Promoter 0.6 EPDnew 600.4 +6.0 5960 0.1 ATF7 ESR1 BCL11A CREB1 BCL11B ATF2 TTLL10-AS1 TTLL10 TNFRSF18
GH01J001156 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 20.5 -15.2 -15243 4.4 HNRNPL GATAD2A IKZF1 JUND LARP7 MTA2 RBFOX2 ZNF24 ZNF740 IKZF2 ENSG00000272141 TTLL10 ATAD3B INTS11 TTLL10-AS1 SLC35E2A LINC01409 LINC01786 UBE2J2 LINC00115
GH01J001131 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 19.9 -38.6 -38629 6.5 SP1 HNRNPL PRDM10 RFX1 LEF1 IKZF1 DDX20 ZIC2 PKNOX1 PATZ1 LINC01342 HSALNG0000093 TTLL10 TTLL10-AS1 SDF4 B3GALT6 C1QTNF12 UBE2J2 C1orf159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTLL10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTLL10

Top Transcription factor binding sites by QIAGEN in the TTLL10 gene promoter:
  • Pax-6
  • POU2F1
  • POU2F1a
  • POU2F1b
  • SEF-1 (1)
  • Sp1

Genomic Locations for TTLL10 Gene

Genomic Locations for TTLL10 Gene
chr1:1,173,709-1,197,936
(GRCh38/hg38)
Size:
24,228 bases
Orientation:
Plus strand
chr1:1,109,264-1,133,315
(GRCh37/hg19)
Size:
24,052 bases
Orientation:
Plus strand

Genomic View for TTLL10 Gene

Genes around TTLL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL10 Gene

Proteins for TTLL10 Gene

  • Protein details for TTLL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVT0-TTL10_HUMAN
    Recommended name:
    Inactive polyglycylase TTLL10
    Protein Accession:
    Q6ZVT0
    Secondary Accessions:
    • B1AMF6
    • Q5T2W4
    • Q5T2W5
    • Q8N9X2

    Protein attributes for TTLL10 Gene

    Size:
    673 amino acids
    Molecular mass:
    75042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL10 Gene

Post-translational modifications for TTLL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL10 Gene

Domains & Families for TTLL10 Gene

Gene Families for TTLL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL10 Gene

InterPro:
Blocks:
  • Tubulin-tyrosine ligase
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL10 Gene

GenScript: Design optimal peptide antigens:
  • Tubulin--tyrosine ligase-like protein 10 (TTL10_HUMAN)
genes like me logo Genes that share domains with TTLL10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTLL10 Gene

Function for TTLL10 Gene

Molecular function for TTLL10 Gene

UniProtKB/Swiss-Prot Function:
Inactive polyglycylase.

Phenotypes From GWAS Catalog for TTLL10 Gene

Gene Ontology (GO) - Molecular Function for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 18331838
GO:0005524 ATP binding IEA --
GO:0070735 NOT protein-glycine ligase activity IDA 19524510
genes like me logo Genes that share ontologies with TTLL10: view
genes like me logo Genes that share phenotypes with TTLL10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL10 Gene

Localization for TTLL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL10 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TTLL10 Gene

Pathways & Interactions for TTLL10 Gene

PathCards logo

SuperPathways for TTLL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation TAS --
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL10 Gene

Drugs & Compounds for TTLL10 Gene

No Compound Related Data Available

Transcripts for TTLL10 Gene

mRNA/cDNA for TTLL10 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTLL10

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for TTLL10 Gene

GeneLoc Exon Structure for
TTLL10

Expression for TTLL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTLL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTLL10 Gene

This gene is overexpressed in Testis (x32.5) and Fallopian Tube (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTLL10

SOURCE GeneReport for Unigene cluster for TTLL10 Gene:

Hs.454835

Evidence on tissue expression from TISSUES for TTLL10 Gene

  • Nervous system(2.6)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with TTLL10: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL10 Gene

Orthologs for TTLL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTLL10 30 31
  • 98.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC489601 30
  • 81.45 (n)
TTLL10 31
  • 63 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TTLL10 30 31
  • 79.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttll10 30 17 31
  • 78.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttll10 30
  • 73.66 (n)
Oppossum
(Monodelphis domestica)
Mammalia TTLL10 31
  • 45 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TTLL10 31
  • 62 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTLL10 31
  • 51 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ttll10 31
  • 40 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 31
  • 11 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Species where no ortholog for TTLL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTLL10 Gene

ENSEMBL:
Gene Tree for TTLL10 (if available)
TreeFam:
Gene Tree for TTLL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTLL10: view image

Paralogs for TTLL10 Gene

genes like me logo Genes that share paralogs with TTLL10: view

Variants for TTLL10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTLL10 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs139755178 A colorectal cancer sample p.Ala130Thr
rs1320571 - p.Ser448Asn
rs13374146 - p.Val249Ala
rs2274791 - p.Gly578Asp

Additional dbSNP identifiers (rs#s) for TTLL10 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTLL10 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv3335892 CNV duplication 20981092
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1110655 CNV insertion 24896259
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv544956 CNV loss 21841781
nsv829536 CNV gain 20364138
nsv950452 CNV deletion 24416366

Variation tolerance for TTLL10 Gene

Gene Damage Index Score: 10.13; 90.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL10 Gene

Disorders for TTLL10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TTLL10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 16
  • cord16
cone-rod dystrophy 18
  • cord18
achromatopsia
  • achromatopsia 2
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TTLL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTLL10 Gene

Publications for TTLL10 Gene

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K … Janke C (Cell 2009) 3 4
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for TTLL10 Gene

Sources for TTLL10 Gene