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Aliases for TTLL10 Gene

Aliases for TTLL10 Gene

  • Tubulin Tyrosine Ligase Like 10 2 3 5
  • Tubulin Tyrosine Ligase-Like Family, Member 5 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 10 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 10 3
  • Tubulin Tyrosine Ligase-Like Family Member 10 2
  • Inactive Polyglycylase TTLL10 3
  • TTLL5 3

External Ids for TTLL10 Gene

Previous HGNC Symbols for TTLL10 Gene

  • TTLL5

Previous GeneCards Identifiers for TTLL10 Gene

  • GC01P001156
  • GC01P000380
  • GC01P001140

Summaries for TTLL10 Gene

GeneCards Summary for TTLL10 Gene

TTLL10 (Tubulin Tyrosine Ligase Like 10) is a Protein Coding gene. Diseases associated with TTLL10 include Fundus Dystrophy. Gene Ontology (GO) annotations related to this gene include protein-glycine ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot for TTLL10 Gene

  • Inactive polyglycylase.

Additional gene information for TTLL10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL10 Gene

Genomics for TTLL10 Gene

GeneHancer (GH) Regulatory Elements for TTLL10 Gene

Promoters and enhancers for TTLL10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I001172 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 555.9 +0.0 34 2 CTCF USF1 RFX1 CEBPB ARID4B BMI1 RAD21 EGR1 POLR2A RFX3 TTLL10 ANKRD65 ACAP3 TTLL10-AS1 GC01M001138
GH01I001179 Promoter 0.8 EPDnew 550.4 +5.8 5785 0.1 RING1 BCL11A CREB1 ATF7 ATF2 BCL11B TTLL10-AS1 TTLL10 LOC105378580 ATAD3B INTS11 CICP3 LINC01786 LINC00115 ENSG00000240731 ENSG00000272455
GH01I001156 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -15.4 -15449 4.4 HDGF ATF1 ARID4B ZNF48 POLR2B ZNF766 ATF7 SP5 NCOA1 ZHX2 GC01P001160 LINC01786 TTLL10 ATAD3B LOC105378580 TTLL10-AS1 INTS11 CICP3 UBE2J2 LINC00115
GH01I001127 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.5 -44.6 -44642 4 FOXA2 ARID4B DMAP1 ZNF48 RAD21 YY1 CREM THAP11 EGR2 MCM3 GC01M001125 SDF4 TTLL10 MXRA8 TTLL10-AS1 ENSG00000230092 B3GALT6 C1QTNF12 UBE2J2 LOC100288379
GH01I001131 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.9 -38.8 -38804 6.5 ELF3 PKNOX1 NFRKB BMI1 RAD21 EGR1 SCRT2 ATF7 IKZF2 RUNX3 LINC01342 TTLL10 TTLL10-AS1 B3GALT6 SDF4 C1QTNF12 UBE2J2 C1orf159 GC01M001125 GC01M001138
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTLL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTLL10 gene promoter:

Genomic Locations for TTLL10 Gene

Genomic Locations for TTLL10 Gene
24,052 bases
Plus strand

Genomic View for TTLL10 Gene

Genes around TTLL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL10 Gene

Proteins for TTLL10 Gene

  • Protein details for TTLL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive polyglycylase TTLL10
    Protein Accession:
    Secondary Accessions:
    • B1AMF6
    • Q5T2W4
    • Q5T2W5
    • Q8N9X2

    Protein attributes for TTLL10 Gene

    673 amino acids
    Molecular mass:
    75042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL10 Gene


neXtProt entry for TTLL10 Gene

Post-translational modifications for TTLL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL10 Gene

Domains & Families for TTLL10 Gene

Gene Families for TTLL10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL10 Gene

Suggested Antigen Peptide Sequences for TTLL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTLL10: view

No data available for UniProtKB/Swiss-Prot for TTLL10 Gene

Function for TTLL10 Gene

Molecular function for TTLL10 Gene

UniProtKB/Swiss-Prot Function:
Inactive polyglycylase.

Phenotypes From GWAS Catalog for TTLL10 Gene

Gene Ontology (GO) - Molecular Function for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18331838
GO:0005524 ATP binding IEA --
GO:0070735 protein-glycine ligase activity TAS --
genes like me logo Genes that share ontologies with TTLL10: view

Phenotypes for TTLL10 Gene

MGI mutant phenotypes for TTLL10:
inferred from 1 alleles
GenomeRNAi human phenotypes for TTLL10:
genes like me logo Genes that share phenotypes with TTLL10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL10 Gene

Localization for TTLL10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL10 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TTLL10 Gene

Pathways & Interactions for TTLL10 Gene

SuperPathways for TTLL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation TAS --
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL10 Gene

Drugs & Compounds for TTLL10 Gene

No Compound Related Data Available

Transcripts for TTLL10 Gene

Unigene Clusters for TTLL10 Gene

Tubulin tyrosine ligase-like family, member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP4: -

Relevant External Links for TTLL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL10 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL10 Gene

This gene is overexpressed in Testis (x32.5) and Fallopian Tube (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of TTLL10 Gene:


SOURCE GeneReport for Unigene cluster for TTLL10 Gene:


Evidence on tissue expression from TISSUES for TTLL10 Gene

  • Stomach(2.1)
genes like me logo Genes that share expression patterns with TTLL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL10 Gene

Orthologs for TTLL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTLL10 33 34
  • 98.46 (n)
(Canis familiaris)
Mammalia LOC489601 33
  • 81.45 (n)
TTLL10 34
  • 63 (a)
(Bos Taurus)
Mammalia TTLL10 33 34
  • 79.53 (n)
(Mus musculus)
Mammalia Ttll10 33 16 34
  • 78.21 (n)
(Rattus norvegicus)
Mammalia Ttll10 33
  • 73.66 (n)
(Monodelphis domestica)
Mammalia TTLL10 34
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
(Gallus gallus)
Aves TTLL10 34
  • 62 (a)
(Anolis carolinensis)
Reptilia TTLL10 34
  • 51 (a)
(Danio rerio)
Actinopterygii ttll10 34
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 34
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
Species where no ortholog for TTLL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL10 Gene

Gene Tree for TTLL10 (if available)
Gene Tree for TTLL10 (if available)

Paralogs for TTLL10 Gene

genes like me logo Genes that share paralogs with TTLL10: view

Variants for TTLL10 Gene

Sequence variations from dbSNP and Humsavar for TTLL10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs139755178 A colorectal cancer sample 1,180,222(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000034101 -- 1,178,288(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000132549 -- 1,179,978(+) C/T intron_variant
rs1000228326 -- 1,185,198(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000283500 -- 1,190,190(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL10 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv3335892 CNV duplication 20981092
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1110655 CNV insertion 24896259
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv544956 CNV loss 21841781
nsv829536 CNV gain 20364138
nsv950452 CNV deletion 24416366

Variation tolerance for TTLL10 Gene

Gene Damage Index Score: 10.13; 90.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL10 Gene

Disorders for TTLL10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTLL10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TTLL10

genes like me logo Genes that share disorders with TTLL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTLL10 Gene

Publications for TTLL10 Gene

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K … Janke C (Cell 2009) 3 4 58
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for TTLL10 Gene

Sources for TTLL10 Gene

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