Aliases for TTK Gene
External Ids for TTK Gene
Previous GeneCards Identifiers for TTK Gene
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
GeneCards Summary for TTK Gene
TTK (TTK Protein Kinase) is a Protein Coding gene. Diseases associated with TTK include Polyposis Syndrome, Hereditary Mixed, 1 and Pancreatic Cancer. Among its related pathways are Cell cycle and Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK2.
UniProtKB/Swiss-Prot Summary for TTK Gene
Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).
Monopolar spindle 1 (Mps1) kinase, also known as TTK protein kinase, is a mitotic kinase that is critical in the regulation of cell division, as it is involved in controlling the progression of cells through mitosis. It is widely found, but is not ubiquitous, in eukaryotes.