Aliases for TTC9C Gene

Aliases for TTC9C Gene

  • Tetratricopeptide Repeat Domain 9C 2 3 5
  • Tetratricopeptide Repeat Protein 9C 3 4
  • TPR Repeat Protein 9C 3 4
  • MGC29649 2
  • TTC9C 5

External Ids for TTC9C Gene

Previous GeneCards Identifiers for TTC9C Gene

  • GC11P062254
  • GC11P062495
  • GC11P058825

Summaries for TTC9C Gene

GeneCards Summary for TTC9C Gene

TTC9C (Tetratricopeptide Repeat Domain 9C) is a Protein Coding gene. An important paralog of this gene is TTC9.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC9C Gene

Genomics for TTC9C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC9C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC9C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC9C

Top Transcription factor binding sites by QIAGEN in the TTC9C gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • GR
  • GR-alpha
  • Max

Genomic Locations for TTC9C Gene

Latest Assembly
chr11:62,728,069-62,740,293
(GRCh38/hg38)
Size:
12,225 bases
Orientation:
Plus strand

Previous Assembly
chr11:62,495,649-62,506,108
(GRCh37/hg19 by Entrez Gene)
Size:
10,460 bases
Orientation:
Plus strand

chr11:62,495,541-62,507,765
(GRCh37/hg19 by Ensembl)
Size:
12,225 bases
Orientation:
Plus strand

Genomic View for TTC9C Gene

Genes around TTC9C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9C Gene

Proteins for TTC9C Gene

  • Protein details for TTC9C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5M4-TTC9C_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9C
    Protein Accession:
    Q8N5M4
    Secondary Accessions:
    • Q8WYY7

    Protein attributes for TTC9C Gene

    Size:
    171 amino acids
    Molecular mass:
    20013 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC9C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC9C Gene

Post-translational modifications for TTC9C Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC9C Gene

Domains & Families for TTC9C Gene

Gene Families for TTC9C Gene

Protein Domains for TTC9C Gene

Suggested Antigen Peptide Sequences for TTC9C Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 9C (TTC9C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5M4

UniProtKB/Swiss-Prot:

TTC9C_HUMAN :
  • Belongs to the TTC9 family.
Family:
  • Belongs to the TTC9 family.
genes like me logo Genes that share domains with TTC9C: view

Function for TTC9C Gene

Phenotypes From GWAS Catalog for TTC9C Gene

Gene Ontology (GO) - Molecular Function for TTC9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC9C: view
genes like me logo Genes that share phenotypes with TTC9C: view

miRNA for TTC9C Gene

miRTarBase miRNAs that target TTC9C

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC9C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC9C Gene

Localization for TTC9C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC9C gene
Compartment Confidence
nucleus 3
extracellular 1
cytoskeleton 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC9C Gene

Pathways & Interactions for TTC9C Gene

PathCards logo

SuperPathways for TTC9C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC9C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC9C Gene

Drugs & Compounds for TTC9C Gene

No Compound Related Data Available

Transcripts for TTC9C Gene

mRNA/cDNA for TTC9C Gene

6 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC9C

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9C Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: -
SP4: - - - - - -
SP5: -
SP6:

Relevant External Links for TTC9C Gene

GeneLoc Exon Structure for
TTC9C

Expression for TTC9C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC9C Gene

Protein differential expression in normal tissues from HIPED for TTC9C Gene

This gene is overexpressed in Bone (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC9C Gene



Protein tissue co-expression partners for TTC9C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC9C

SOURCE GeneReport for Unigene cluster for TTC9C Gene:

Hs.31704
genes like me logo Genes that share expression patterns with TTC9C: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC9C Gene

Orthologs for TTC9C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC9C 29 30
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 92 (a)
OneToMany
-- 30
  • 92 (a)
OneToMany
TTC9C 29 30
  • 90.64 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia TTC9C 29 30
  • 89.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc9c 29
  • 89.28 (n)
Mouse
(Mus musculus)
Mammalia Ttc9c 29 16 30
  • 88.3 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TTC9C 30
  • 85 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC9C 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc9c 29
  • 57.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii ttc9c 29 30
  • 58.43 (n)
OneToOne
Species where no ortholog for TTC9C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTC9C Gene

ENSEMBL:
Gene Tree for TTC9C (if available)
TreeFam:
Gene Tree for TTC9C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC9C: view image
Alliance of Genome Resources:
Additional Orthologs for TTC9C

Paralogs for TTC9C Gene

(2) SIMAP similar genes for TTC9C Gene using alignment to 5 proteins:

  • TTC9C_HUMAN
  • E7EST3_HUMAN
  • E9PKV8_HUMAN
  • H0YDR3_HUMAN
  • Q8WYY7_HUMAN
genes like me logo Genes that share paralogs with TTC9C: view

Variants for TTC9C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TTC9C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TTC9C Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for TTC9C Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC9C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC9C
Leiden Open Variation Database (LOVD)
TTC9C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC9C Gene

Disorders for TTC9C Gene

Additional Disease Information for TTC9C

No disorders were found for TTC9C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC9C Gene

Publications for TTC9C Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3
  3. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. (PMID: 33001583) Mao CG … Deng B (Thoracic cancer 2020) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for TTC9C Gene

Sources for TTC9C Gene