Aliases for TTC9B Gene

Aliases for TTC9B Gene

  • Tetratricopeptide Repeat Domain 9B 2 3 5
  • Tetratricopeptide Repeat Protein 9B 3 4
  • TPR Repeat Protein 9B 3 4
  • FLJ30373 2
  • TTC9B 5

External Ids for TTC9B Gene

Previous GeneCards Identifiers for TTC9B Gene

  • GC19M045417
  • GC19M040721
  • GC19M037156

Summaries for TTC9B Gene

GeneCards Summary for TTC9B Gene

TTC9B (Tetratricopeptide Repeat Domain 9B) is a Protein Coding gene. Diseases associated with TTC9B include Postpartum Depression and Endogenous Depression. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is TTC9.

Additional gene information for TTC9B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC9B Gene

Genomics for TTC9B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC9B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040217 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 +1.2 1198 1.2 CTCF PRDM10 ZNF629 KDM1A RFX1 ZIC2 ZSCAN4 PKNOX1 PATZ1 REST TTC9B SNRPA PLEKHG2 FBL ENSG00000269843 EID2B SERTAD3 RPS16 ITPKC RN7SL566P
GH19J040219 Enhancer 1.1 FANTOM5 ENCODE 600.7 -1.7 -1672 1.5 PRDM10 ZNF629 ZNF692 JUND PRDM1 ZSCAN4 ZNF24 PATZ1 REST ZNF501 TTC9B ENSG00000269843 SNRPA FBL ITPKC RPS16 ZNF780A ZNF780B PLEKHG2 AKT2
GH19J040220 Promoter/Enhancer 1.1 EPDnew ENCODE 600.7 0.0 0 0.1 REST KDM1A ZNF692 ZNF143 POLR2A PATZ1 RCOR1 ZNF341 ZNF561 ZBTB44 TTC9B lnc-TTC9B-1 NONHSAG025820.2 MAP3K10
GH19J040190 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.5 +26.9 26898 3 HNRNPL PRDM10 ZNF629 SIX5 IKZF1 CTCF ZNF692 POLR2A ZNF174 BACH1 MAP3K10 lnc-TTC9B-2 ZNF780B NUMBL CYP2G1P SUPT5H EID2B PAF1 TTC9B CCNP
GH19J039969 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +247.6 247587 3.6 SP1 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 SIX5 LEF1 PSMC4 lnc-FCGBP-2 piR-56186-028 ZNF780A FCGBP SPTBN4 MAP3K10 AKT2 ENSG00000269843 MED29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC9B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC9B

Top Transcription factor binding sites by QIAGEN in the TTC9B gene promoter:
  • HOXA5
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • Roaz
  • YY1

Genomic Locations for TTC9B Gene

Genomic Locations for TTC9B Gene
chr19:40,216,058-40,218,399
(GRCh38/hg38)
Size:
2,342 bases
Orientation:
Minus strand
chr19:40,721,965-40,724,306
(GRCh37/hg19)
Size:
2,342 bases
Orientation:
Minus strand

Genomic View for TTC9B Gene

Genes around TTC9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9B Gene

Proteins for TTC9B Gene

  • Protein details for TTC9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6N2-TTC9B_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9B
    Protein Accession:
    Q8N6N2
    Secondary Accessions:
    • A8K0I5
    • Q96NP9

    Protein attributes for TTC9B Gene

    Size:
    239 amino acids
    Molecular mass:
    25932 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be due to an intron retention.

    Alternative splice isoforms for TTC9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC9B Gene

Post-translational modifications for TTC9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC9B Gene

Domains & Families for TTC9B Gene

Gene Families for TTC9B Gene

Protein Domains for TTC9B Gene

Suggested Antigen Peptide Sequences for TTC9B Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 9B (TTC9B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6N2

UniProtKB/Swiss-Prot:

TTC9B_HUMAN :
  • Belongs to the TTC9 family.
Family:
  • Belongs to the TTC9 family.
genes like me logo Genes that share domains with TTC9B: view

Function for TTC9B Gene

Phenotypes From GWAS Catalog for TTC9B Gene

Gene Ontology (GO) - Molecular Function for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC9B: view
genes like me logo Genes that share phenotypes with TTC9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC9B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC9B Gene

Localization for TTC9B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC9B gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TTC9B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TTC9B Gene

Pathways & Interactions for TTC9B Gene

PathCards logo

SuperPathways for TTC9B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC9B: view

No data available for Pathways by source and SIGNOR curated interactions for TTC9B Gene

Drugs & Compounds for TTC9B Gene

No Compound Related Data Available

Transcripts for TTC9B Gene

mRNA/cDNA for TTC9B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC9B

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9B Gene

No ASD Table

Relevant External Links for TTC9B Gene

GeneLoc Exon Structure for
TTC9B

Expression for TTC9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC9B Gene

This gene is overexpressed in Brain - Amygdala (x7.9), Brain - Cortex (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Cerebellar Hemisphere (x6.0), Brain - Cerebellum (x5.6), Brain - Frontal Cortex (BA9) (x5.3), and Brain - Hippocampus (x5.1).

Protein differential expression in normal tissues from HIPED for TTC9B Gene

This gene is overexpressed in Brain (54.5) and Frontal cortex (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC9B Gene



Protein tissue co-expression partners for TTC9B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC9B

SOURCE GeneReport for Unigene cluster for TTC9B Gene:

Hs.631572

Evidence on tissue expression from TISSUES for TTC9B Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with TTC9B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC9B Gene

Orthologs for TTC9B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC9B 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC9B 30 31
  • 90.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttc9b 30 17 31
  • 89.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc9b 30
  • 88.47 (n)
Cow
(Bos Taurus)
Mammalia TTC9B 30 31
  • 87.94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TTC9B 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTC9B 31
  • 77 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC9B 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc9b 30
  • 64.47 (n)
Zebrafish
(Danio rerio)
Actinopterygii ttc9b 30 31
  • 68.44 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9184 30
Species where no ortholog for TTC9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTC9B Gene

ENSEMBL:
Gene Tree for TTC9B (if available)
TreeFam:
Gene Tree for TTC9B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC9B: view image

Paralogs for TTC9B Gene

(2) SIMAP similar genes for TTC9B Gene using alignment to 1 proteins:

  • TTC9B_HUMAN
genes like me logo Genes that share paralogs with TTC9B: view

Variants for TTC9B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC9B Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11553464 - p.Leu223Pro

Additional dbSNP identifiers (rs#s) for TTC9B Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC9B Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372
nsv9728 CNV loss 18304495

Variation tolerance for TTC9B Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC9B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9B Gene

Disorders for TTC9B Gene

MalaCards: The human disease database

(2) MalaCards diseases for TTC9B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
postpartum depression
  • maternity blues
endogenous depression
  • unipolar depression
- elite association - COSMIC cancer census association via MalaCards
Search TTC9B in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TTC9B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC9B Gene

Publications for TTC9B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels. (PMID: 26503311) Osborne L … Kaminsky Z (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016) 3
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R … Aloy P (Journal of molecular biology 2015) 3
  5. Seeing the future: epigenetic biomarkers of postpartum depression. (PMID: 24317310) Kaminsky Z … Payne J (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014) 3

Products for TTC9B Gene

Sources for TTC9B Gene