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Aliases for TTC9B Gene

Aliases for TTC9B Gene

  • Tetratricopeptide Repeat Domain 9B 2 3 5
  • TPR Repeat Protein 9B 3 4
  • Tetratricopeptide Repeat Protein 9B 3

External Ids for TTC9B Gene

Previous GeneCards Identifiers for TTC9B Gene

  • GC19M045417
  • GC19M040721
  • GC19M037156

Summaries for TTC9B Gene

GeneCards Summary for TTC9B Gene

TTC9B (Tetratricopeptide Repeat Domain 9B) is a Protein Coding gene. Diseases associated with TTC9B include Endogenous Depression. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is TTC9.

Additional gene information for TTC9B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9B Gene

Genomics for TTC9B Gene

GeneHancer (GH) Regulatory Elements for TTC9B Gene

Promoters and enhancers for TTC9B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040219 Enhancer 1.4 FANTOM5 Ensembl ENCODE 650.7 -1.7 -1672 1.5 SIN3A ZNF2 GLIS2 ZFP91 FOS KLF13 SP3 YY2 REST ZNF518A TTC9B ENSG00000269843 SNRPA FBL ITPKC RPS16 ZNF780A ZNF780B LGALS14 ENSG00000269792
GH19J040220 Promoter/Enhancer 1.3 EPDnew ENCODE 650.7 0.0 0 0.1 HDAC1 RB1 KLF17 SIN3A KLF14 ZNF766 GLIS2 E2F8 ZNF143 RCOR1 TTC9B CNTD2
GH19J040217 Enhancer 0.9 ENCODE 650.7 +1.2 1150 0.2 PKNOX1 RB1 SIN3A ZNF2 RAD21 ZEB1 ZNF335 GLIS2 EGR1 ZNF366 TTC9B ENSG00000269843 SNRPA PLEKHG2 GC19P040214
GH19J040218 Enhancer 0.9 ENCODE 650.7 +0.9 890 0.2 RB1 KLF17 SIN3A ZNF2 RAD21 ZEB1 ZNF335 GLIS2 EGR1 SCRT2 TTC9B SNRPA ENSG00000269843 FBL RN7SL566P AKT2 PLEKHG2 ZNF780A COQ8B ITPKC
GH19J040190 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 12.5 +27.2 27161 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF213 MAP3K10 ZNF780B NUMBL SNRPA ENSG00000269843 CYP2G1P FBL PSMC4 SUPT5H EID2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC9B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC9B gene promoter:
  • NRSF form 1
  • NRSF form 2
  • HOXA5
  • Roaz
  • NF-1
  • Pax-4a
  • YY1

Genomic Locations for TTC9B Gene

Genomic Locations for TTC9B Gene
2,342 bases
Minus strand
2,342 bases
Minus strand

Genomic View for TTC9B Gene

Genes around TTC9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9B Gene

Proteins for TTC9B Gene

  • Protein details for TTC9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 9B
    Protein Accession:
    Secondary Accessions:
    • A8K0I5
    • Q96NP9

    Protein attributes for TTC9B Gene

    239 amino acids
    Molecular mass:
    25932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC9B Gene


neXtProt entry for TTC9B Gene

Post-translational modifications for TTC9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC9B Gene

Domains & Families for TTC9B Gene

Gene Families for TTC9B Gene

Protein Domains for TTC9B Gene

Suggested Antigen Peptide Sequences for TTC9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TTC9 family.
  • Belongs to the TTC9 family.
genes like me logo Genes that share domains with TTC9B: view

Function for TTC9B Gene

Gene Ontology (GO) - Molecular Function for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC9B: view
genes like me logo Genes that share phenotypes with TTC9B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC9B Gene

Localization for TTC9B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC9B gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TTC9B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TTC9B Gene

Pathways & Interactions for TTC9B Gene

SuperPathways for TTC9B Gene

No Data Available

Interacting Proteins for TTC9B Gene

Gene Ontology (GO) - Biological Process for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC9B: view

No data available for Pathways by source and SIGNOR curated interactions for TTC9B Gene

Drugs & Compounds for TTC9B Gene

No Compound Related Data Available

Transcripts for TTC9B Gene

mRNA/cDNA for TTC9B Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC9B Gene

Tetratricopeptide repeat domain 9B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9B Gene

No ASD Table

Relevant External Links for TTC9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC9B Gene

This gene is overexpressed in Brain - Amygdala (x7.9), Brain - Cortex (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Cerebellar Hemisphere (x6.0), Brain - Cerebellum (x5.6), Brain - Frontal Cortex (BA9) (x5.3), and Brain - Hippocampus (x5.1).

Protein differential expression in normal tissues from HIPED for TTC9B Gene

This gene is overexpressed in Brain (54.5) and Frontal cortex (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC9B Gene

Protein tissue co-expression partners for TTC9B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC9B Gene:


SOURCE GeneReport for Unigene cluster for TTC9B Gene:


Evidence on tissue expression from TISSUES for TTC9B Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with TTC9B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC9B Gene

Orthologs for TTC9B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC9B 34
  • 98 (a)
(Canis familiaris)
Mammalia TTC9B 34 33
  • 90.78 (n)
(Mus musculus)
Mammalia Ttc9b 16 34 33
  • 89.03 (n)
(Rattus norvegicus)
Mammalia Ttc9b 33
  • 88.47 (n)
(Bos Taurus)
Mammalia TTC9B 34 33
  • 87.94 (n)
(Monodelphis domestica)
Mammalia TTC9B 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TTC9B 34
  • 77 (a)
(Anolis carolinensis)
Reptilia TTC9B 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc9b 33
  • 64.47 (n)
(Danio rerio)
Actinopterygii ttc9b 34 33
  • 68.44 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9184 33
Species where no ortholog for TTC9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9B Gene

Gene Tree for TTC9B (if available)
Gene Tree for TTC9B (if available)
Evolutionary constrained regions (ECRs) for TTC9B: view image

Paralogs for TTC9B Gene

Paralogs for TTC9B Gene

(2) SIMAP similar genes for TTC9B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC9B: view

Variants for TTC9B Gene

Sequence variations from dbSNP and Humsavar for TTC9B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000490061 -- 40,217,548(-) C/A intron_variant
rs1000752459 -- 40,218,558(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000819645 -- 40,217,357(-) T/C coding_sequence_variant, missense_variant
rs1000995801 -- 40,220,234(-) G/A upstream_transcript_variant
rs1001225345 -- 40,218,805(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC9B Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372
nsv9728 CNV loss 18304495

Variation tolerance for TTC9B Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9B Gene

Disorders for TTC9B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC9B Gene - From: DISEASES

Disorder Aliases PubMed IDs
endogenous depression
  • unipolar depression
- elite association - COSMIC cancer census association via MalaCards
Search TTC9B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTC9B

genes like me logo Genes that share disorders with TTC9B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC9B Gene

Publications for TTC9B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels. (PMID: 26503311) Osborne L … Kaminsky Z (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016) 3 58
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R … Aloy P (Journal of molecular biology 2015) 3 58
  5. Seeing the future: epigenetic biomarkers of postpartum depression. (PMID: 24317310) Kaminsky Z … Payne J (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014) 3 58

Products for TTC9B Gene

Sources for TTC9B Gene

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