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Aliases for TTC9 Gene

Aliases for TTC9 Gene

  • Tetratricopeptide Repeat Domain 9 2 3 5
  • TPR Repeat Protein 9A 3 4
  • TTC9A 3 4
  • Tetratricopeptide Repeat Protein 9A 3
  • KIAA0227 4

External Ids for TTC9 Gene

Previous GeneCards Identifiers for TTC9 Gene

  • GC14P069090
  • GC14P070177
  • GC14P071110
  • GC14P051277

Summaries for TTC9 Gene

Entrez Gene Summary for TTC9 Gene

  • This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009]

GeneCards Summary for TTC9 Gene

TTC9 (Tetratricopeptide Repeat Domain 9) is a Protein Coding gene. An important paralog of this gene is TTC9B.

Additional gene information for TTC9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9 Gene

Genomics for TTC9 Gene

GeneHancer (GH) Regulatory Elements for TTC9 Gene

Promoters and enhancers for TTC9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I070640 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 616.9 +0.6 586 3.9 PKNOX1 SIN3A IRF4 GLIS2 ZNF143 KLF7 FOS RUNX3 GLIS1 SP7 TTC9 LOC101928075 ENSG00000259115 GC14P070643 MED6
GH14I070652 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +19.5 19454 17.5 HDGF PKNOX1 FOXA2 SMAD1 NEUROD1 SIN3A ZBTB7B IRF4 ETS1 ZNF207 SRSF5 TTC9 MED6 SYNJ2BP GC14P070671 GC14P070643 GC14M070669
GH14I070697 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +56.6 56557 1.5 MAX BACH1 ZNF644 ZNF316 FOSL2 NFE2 FOS MAFK NFE2L2 ZNF639 LINC01269 TTC9 LOC101928075 MED6 GC14M070669
GH14I070706 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.4 +66.6 66576 4.4 FOXA2 MLX FEZF1 IRF4 ATF7 FOS RUNX3 SP5 JUNB NFIL3 LOC101928075 TTC9 GC14P070715 LINC01269
GH14I070713 Enhancer 0.7 ENCODE 11.8 +72.2 72235 1 CTCF ZNF384 EBF1 YBX1 RAD21 ZNF335 ZNF366 ZNF143 SMC3 ATF7 GC14P070715 LOC101928075 TTC9 LINC01269
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC9 gene promoter:

Genomic Locations for TTC9 Gene

Genomic Locations for TTC9 Gene
chr14:70,641,787-70,675,360
(GRCh38/hg38)
Size:
33,574 bases
Orientation:
Plus strand
chr14:71,108,504-71,142,077
(GRCh37/hg19)

Genomic View for TTC9 Gene

Genes around TTC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9 Gene

Proteins for TTC9 Gene

  • Protein details for TTC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92623-TTC9A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9A
    Protein Accession:
    Q92623
    Secondary Accessions:
    • Q86WT2

    Protein attributes for TTC9 Gene

    Size:
    222 amino acids
    Molecular mass:
    24379 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA13216.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TTC9 Gene

Post-translational modifications for TTC9 Gene

No Post-translational modifications

Other Protein References for TTC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC9 Gene

Domains & Families for TTC9 Gene

Gene Families for TTC9 Gene

Protein Domains for TTC9 Gene

Suggested Antigen Peptide Sequences for TTC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92623

UniProtKB/Swiss-Prot:

TTC9A_HUMAN :
  • Belongs to the TTC9 family.
Family:
  • Belongs to the TTC9 family.
genes like me logo Genes that share domains with TTC9: view

Function for TTC9 Gene

Phenotypes From GWAS Catalog for TTC9 Gene

genes like me logo Genes that share phenotypes with TTC9: view

Animal Models for TTC9 Gene

MGI Knock Outs for TTC9:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTC9 Gene

Localization for TTC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC9 gene
Compartment Confidence
extracellular 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TTC9 Gene

Pathways & Interactions for TTC9 Gene

No Data Available

Interacting Proteins for TTC9 Gene

Gene Ontology (GO) - Biological Process for TTC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with TTC9: view

No data available for Pathways by source and SIGNOR curated interactions for TTC9 Gene

Drugs & Compounds for TTC9 Gene

No Compound Related Data Available

Transcripts for TTC9 Gene

mRNA/cDNA for TTC9 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC9 Gene

Tetratricopeptide repeat domain 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9 Gene

No ASD Table

Relevant External Links for TTC9 Gene

GeneLoc Exon Structure for
TTC9
ECgene alternative splicing isoforms for
TTC9

Expression for TTC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC9 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9).

Protein differential expression in normal tissues from HIPED for TTC9 Gene

This gene is overexpressed in Cervix (30.8), Brain (12.5), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC9 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC9 Gene:

TTC9

SOURCE GeneReport for Unigene cluster for TTC9 Gene:

Hs.79170

Evidence on tissue expression from TISSUES for TTC9 Gene

  • Nervous system(4.6)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with TTC9: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC9 Gene

Orthologs for TTC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC9 33 34
  • 95.35 (n)
cow
(Bos Taurus)
Mammalia TTC9 33 34
  • 92.8 (n)
dog
(Canis familiaris)
Mammalia TTC9 33 34
  • 91.48 (n)
rat
(Rattus norvegicus)
Mammalia Ttc9 33
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Ttc9 33 16 34
  • 85.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC9 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC9 33 34
  • 80.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc9 33
  • 74.51 (n)
Str.20173 33
zebrafish
(Danio rerio)
Actinopterygii LOC560706 33
  • 69.01 (n)
TTC9 34
  • 68 (a)
OneToOne
Species where no ortholog for TTC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9 Gene

ENSEMBL:
Gene Tree for TTC9 (if available)
TreeFam:
Gene Tree for TTC9 (if available)

Paralogs for TTC9 Gene

Paralogs for TTC9 Gene

(2) SIMAP similar genes for TTC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC9: view

Variants for TTC9 Gene

Sequence variations from dbSNP and Humsavar for TTC9 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000048408 -- 70,657,701(+) C/G intron_variant
rs1000205643 -- 70,668,887(+) T/G intron_variant
rs1000231769 -- 70,654,125(+) C/A intron_variant
rs1000246974 -- 70,658,075(+) C/T intron_variant
rs1000281620 -- 70,661,287(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC9 Gene

Variant ID Type Subtype PubMed ID
nsv1143754 CNV deletion 24896259
nsv1070227 CNV deletion 25765185
esv3634866 CNV loss 21293372
esv3581281 CNV loss 25503493
esv2672447 CNV deletion 23128226

Variation tolerance for TTC9 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9 Gene

Disorders for TTC9 Gene

Additional Disease Information for TTC9

No disorders were found for TTC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC9 Gene

Publications for TTC9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  3. Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. (PMID: 25798063) Shrestha S … Lin VC (International journal of biological sciences 2015) 3 58
  4. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. (PMID: 25217961) Al Olama AA … Haiman CA (Nature genetics 2014) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for TTC9 Gene

Sources for TTC9 Gene

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