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Aliases for TTC5 Gene

Aliases for TTC5 Gene

  • Tetratricopeptide Repeat Domain 5 2 3 5
  • Stress-Responsive Activator Of P300 3 4
  • TPR Repeat Protein 5 3 4
  • STRAP 3 4
  • Tetratricopeptide Repeat Protein 5 3

External Ids for TTC5 Gene

Previous GeneCards Identifiers for TTC5 Gene

  • GC14M018748
  • GC14M018749
  • GC14M019827
  • GC14M020757
  • GC14M000879

Summaries for TTC5 Gene

GeneCards Summary for TTC5 Gene

TTC5 (Tetratricopeptide Repeat Domain 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TTC5 Gene

  • Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

Additional gene information for TTC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC5 Gene

Genomics for TTC5 Gene

GeneHancer (GH) Regulatory Elements for TTC5 Gene

Promoters and enhancers for TTC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I020305 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.9 +0.2 208 1.6 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF207 ZNF143 DEK TTC5 ENSG00000258459 ENSG00000258768 METTL17 ENSG00000258515 OSGEP
GH14I020679 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22 -378.5 -378539 9.8 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RNASE4 ANG ENSG00000259171 PIR55020 TRP-TGG3-2 TRY-GTA5-5 METTL3 ENSG00000258515 SUPT16H CHD8
GH14I020453 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.4 -149.5 -149549 3.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 SP3 NFYC OSGEP APEX1 SUPT16H METTL17 ENSG00000258515 TEP1 TTC5 PIP4P1 ZNF219 PNP
GH14I020657 Enhancer 1.2 Ensembl ENCODE 33 -351.7 -351733 1.1 HDGF PKNOX1 SIN3A ZNF2 ZNF213 ZNF143 ZNF548 FOS KLF13 SP3 TRY-GTA4-1 METTL3 SUPT16H METTL17 ENSG00000258515 PARP2 TTC5 CHD8 RAB2B ENSG00000258768
GH14I020609 Promoter/Enhancer 1.6 Ensembl ENCODE 22 -303.9 -303856 1.8 PKNOX1 MLX ARNT ARID4B NEUROD1 SIN3A ZNF2 IRF4 YY1 SLC30A9 ENSG00000259060 RNASE11 TRL-AAG2-3 TRP-AGG2-5 PARP2 SUPT16H METTL3 TTC5 ENSG00000258515 CHD8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC5 gene promoter:

Genomic Locations for TTC5 Gene

Genomic Locations for TTC5 Gene
chr14:20,256,558-20,305,994
(GRCh38/hg38)
Size:
49,437 bases
Orientation:
Minus strand
chr14:20,724,717-20,774,153
(GRCh37/hg19)

Genomic View for TTC5 Gene

Genes around TTC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC5 Gene

Proteins for TTC5 Gene

  • Protein details for TTC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z6-TTC5_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 5
    Protein Accession:
    Q8N0Z6
    Secondary Accessions:
    • A8MQ18
    • Q96HF9

    Protein attributes for TTC5 Gene

    Size:
    440 amino acids
    Molecular mass:
    48928 Da
    Quaternary structure:
    • Interacts with JMY and p300/EP300.

    Three dimensional structures from OCA and Proteopedia for TTC5 Gene

neXtProt entry for TTC5 Gene

Post-translational modifications for TTC5 Gene

  • Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.

Other Protein References for TTC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC5 Gene

Domains & Families for TTC5 Gene

Gene Families for TTC5 Gene

Protein Domains for TTC5 Gene

Suggested Antigen Peptide Sequences for TTC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC5: view

No data available for UniProtKB/Swiss-Prot for TTC5 Gene

Function for TTC5 Gene

Molecular function for TTC5 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

Phenotypes From GWAS Catalog for TTC5 Gene

Gene Ontology (GO) - Molecular Function for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC5: view

Phenotypes for TTC5 Gene

GenomeRNAi human phenotypes for TTC5:
genes like me logo Genes that share phenotypes with TTC5: view

miRNA for TTC5 Gene

miRTarBase miRNAs that target TTC5

Clone Products

  • Addgene plasmids for TTC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC5 Gene

Localization for TTC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC5 Gene

Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TTC5: view

Pathways & Interactions for TTC5 Gene

genes like me logo Genes that share pathways with TTC5: view

Pathways by source for TTC5 Gene

Gene Ontology (GO) - Biological Process for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with TTC5: view

No data available for SIGNOR curated interactions for TTC5 Gene

Drugs & Compounds for TTC5 Gene

No Compound Related Data Available

Transcripts for TTC5 Gene

Unigene Clusters for TTC5 Gene

Tetratricopeptide repeat domain 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for TTC5

Alternative Splicing Database (ASD) splice patterns (SP) for TTC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3: - - -

Relevant External Links for TTC5 Gene

GeneLoc Exon Structure for
TTC5
ECgene alternative splicing isoforms for
TTC5

Expression for TTC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC5 Gene

Protein differential expression in normal tissues from HIPED for TTC5 Gene

This gene is overexpressed in Heart (40.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC5 Gene



Protein tissue co-expression partners for TTC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC5 Gene:

TTC5

SOURCE GeneReport for Unigene cluster for TTC5 Gene:

Hs.98553

Evidence on tissue expression from TISSUES for TTC5 Gene

  • Eye(4.1)
  • Pancreas(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with TTC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC5 Gene

Orthologs for TTC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC5 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia TTC5 33 34
  • 91.36 (n)
mouse
(Mus musculus)
Mammalia Ttc5 33 16 34
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Ttc5 33
  • 86.36 (n)
dog
(Canis familiaris)
Mammalia TTC5 33 34
  • 85.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC5 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC5 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc5 33
  • 66.28 (n)
Str.18743 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11459 33
zebrafish
(Danio rerio)
Actinopterygii ttc5 33 34
  • 60.71 (n)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.1 34
  • 25 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os01g0506200 33
  • 44.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for TTC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC5 Gene

ENSEMBL:
Gene Tree for TTC5 (if available)
TreeFam:
Gene Tree for TTC5 (if available)

Paralogs for TTC5 Gene

(1) SIMAP similar genes for TTC5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TTC5 Gene

genes like me logo Genes that share paralogs with TTC5: view

No data available for Paralogs for TTC5 Gene

Variants for TTC5 Gene

Sequence variations from dbSNP and Humsavar for TTC5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000027711 -- 20,302,313(-) T/C intron_variant
rs1000083352 -- 20,289,130(-) G/GG downstream_transcript_variant
rs1000390776 -- 20,306,660(-) G/A/T upstream_transcript_variant
rs1000414367 -- 20,288,876(-) G/A downstream_transcript_variant
rs1000468637 -- 20,289,082(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC5 Gene

Variant ID Type Subtype PubMed ID
esv3633679 CNV loss 21293372

Variation tolerance for TTC5 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC5 Gene

Disorders for TTC5 Gene

Additional Disease Information for TTC5

No disorders were found for TTC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC5 Gene

Publications for TTC5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A TPR motif cofactor contributes to p300 activity in the p53 response. (PMID: 11511361) Demonacos C … La Thangue NB (Molecular cell 2001) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TTC5 Gene

Sources for TTC5 Gene

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