Aliases for TTC5 Gene

Aliases for TTC5 Gene

  • Tetratricopeptide Repeat Domain 5 2 3 5
  • Strap 2 3 4
  • Stress-Responsive Activator Of P300 3 4
  • Tetratricopeptide Repeat Protein 5 3 4
  • TPR Repeat Protein 5 3 4
  • TTC5 5

External Ids for TTC5 Gene

Previous GeneCards Identifiers for TTC5 Gene

  • GC14M018748
  • GC14M018749
  • GC14M019827
  • GC14M020757
  • GC14M000879

Summaries for TTC5 Gene

GeneCards Summary for TTC5 Gene

TTC5 (Tetratricopeptide Repeat Domain 5) is a Protein Coding gene. Diseases associated with TTC5 include Neurodevelopmental Disorder With Cerebral Atrophy And Variable Facial Dysmorphism. Among its related pathways are p53 pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot Summary for TTC5 Gene

  • Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC5 Gene

Genomics for TTC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC5

Top Transcription factor binding sites by QIAGEN in the TTC5 gene promoter:
  • AML1a
  • Brachyury
  • C/EBPalpha
  • CHOP-10
  • ER-alpha
  • NF-kappaB
  • NF-kappaB1
  • Pbx1a
  • STAT3

Genomic Locations for TTC5 Gene

Latest Assembly
chr14:20,256,558-20,305,960
(GRCh38/hg38)
Size:
49,403 bases
Orientation:
Minus strand

Previous Assembly
chr14:20,754,386-20,774,110
(GRCh37/hg19 by Entrez Gene)
Size:
19,725 bases
Orientation:
Minus strand

chr14:20,724,717-20,774,153
(GRCh37/hg19 by Ensembl)
Size:
49,437 bases
Orientation:
Minus strand

Genomic View for TTC5 Gene

Genes around TTC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC5 Gene

Proteins for TTC5 Gene

  • Protein details for TTC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z6-TTC5_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 5
    Protein Accession:
    Q8N0Z6
    Secondary Accessions:
    • A8MQ18
    • Q96HF9

    Protein attributes for TTC5 Gene

    Size:
    440 amino acids
    Molecular mass:
    48928 Da
    Quaternary structure:
    • Interacts with JMY and p300/EP300.

    Three dimensional structures from OCA and Proteopedia for TTC5 Gene

neXtProt entry for TTC5 Gene

Post-translational modifications for TTC5 Gene

  • Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC5 Gene

No data available for DME Specific Peptides for TTC5 Gene

Domains & Families for TTC5 Gene

Gene Families for TTC5 Gene

Protein Domains for TTC5 Gene

Suggested Antigen Peptide Sequences for TTC5 Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 5 (TTC5_HUMAN)
genes like me logo Genes that share domains with TTC5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC5 Gene

Function for TTC5 Gene

Molecular function for TTC5 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

Phenotypes From GWAS Catalog for TTC5 Gene

Gene Ontology (GO) - Molecular Function for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC5: view

Phenotypes for TTC5 Gene

genes like me logo Genes that share phenotypes with TTC5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC5 Gene

Localization for TTC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC5 Gene

Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC5 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TTC5: view

Pathways & Interactions for TTC5 Gene

genes like me logo Genes that share pathways with TTC5: view

Pathways by source for TTC5 Gene

SIGNOR curated interactions for TTC5 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with TTC5: view

Drugs & Compounds for TTC5 Gene

No Compound Related Data Available

Transcripts for TTC5 Gene

mRNA/cDNA for TTC5 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC5

Alternative Splicing Database (ASD) splice patterns (SP) for TTC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3: - - -

Relevant External Links for TTC5 Gene

GeneLoc Exon Structure for
TTC5

Expression for TTC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC5 Gene

This gene is overexpressed in Heart (40.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC5 Gene



Protein tissue co-expression partners for TTC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC5

SOURCE GeneReport for Unigene cluster for TTC5 Gene:

Hs.98553

Evidence on tissue expression from TISSUES for TTC5 Gene

  • Skin(4.2)
  • Eye(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with TTC5: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC5 Gene

Orthologs for TTC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC5 29 30
  • 99.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TTC5 29 30
  • 91.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttc5 29 16 30
  • 86.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc5 29
  • 86.36 (n)
Dog
(Canis familiaris)
Mammalia TTC5 29 30
  • 85.19 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TTC5 30
  • 80 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC5 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc5 29
  • 66.28 (n)
Str.18743 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.11459 29
Zebrafish
(Danio rerio)
Actinopterygii ttc5 29 30
  • 60.71 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y37E3.1 30
  • 25 (a)
OneToOne
Rice
(Oryza sativa)
Liliopsida Os01g0506200 29
  • 44.73 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToOne
Species where no ortholog for TTC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TTC5 Gene

ENSEMBL:
Gene Tree for TTC5 (if available)
TreeFam:
Gene Tree for TTC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC5: view image
Alliance of Genome Resources:
Additional Orthologs for TTC5

Paralogs for TTC5 Gene

(1) SIMAP similar genes for TTC5 Gene using alignment to 4 proteins:

  • TTC5_HUMAN
  • G3V3I6_HUMAN
  • H0Y6R6_HUMAN
  • H9KV81_HUMAN

Pseudogenes.org Pseudogenes for TTC5 Gene

genes like me logo Genes that share paralogs with TTC5: view

No data available for Paralogs for TTC5 Gene

Variants for TTC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs34675160 -- p.Gln14His
rs3742945 -- p.Gln47Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TTC5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TTC5 Gene

Variant ID Type Subtype PubMed ID
esv3633679 CNV loss 21293372

Variation tolerance for TTC5 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC5
Leiden Open Variation Database (LOVD)
TTC5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC5 Gene

Disorders for TTC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC5 Gene - From: OMI

- elite association - COSMIC cancer census association via MalaCards
Search TTC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTC5

genes like me logo Genes that share disorders with TTC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC5 Gene

Publications for TTC5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A TPR motif cofactor contributes to p300 activity in the p53 response. (PMID: 11511361) Demonacos C … La Thangue NB (Molecular cell 2001) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. TTC5 mediates autoregulation of tubulin via mRNA degradation. (PMID: 31727855) Lin Z … Hegde RS (Science (New York, N.Y.) 2020) 3

Products for TTC5 Gene

Sources for TTC5 Gene