The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016] See more...

Aliases for TTC36 Gene

Aliases for TTC36 Gene

  • Tetratricopeptide Repeat Domain 36 2 3 5
  • HBP21 2 3 4
  • Tetratricopeptide Repeat Protein 36 3 4
  • HSP70 Binding Protein 21 2 3
  • TPR Repeat Protein 36 3 4
  • HSP70-Binding Protein 21 4
  • TTC36 5

External Ids for TTC36 Gene

Previous GeneCards Identifiers for TTC36 Gene

  • GC11P117904
  • GC11P118398
  • GC11P114334

Summaries for TTC36 Gene

Entrez Gene Summary for TTC36 Gene

  • The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]

GeneCards Summary for TTC36 Gene

TTC36 (Tetratricopeptide Repeat Domain 36) is a Protein Coding gene. Diseases associated with TTC36 include Tyrosinemia, Type Iii and Tyrosinemia.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC36 Gene

Genomics for TTC36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC36

Top Transcription factor binding sites by QIAGEN in the TTC36 gene promoter:
  • C/EBPalpha
  • Chx10
  • CUTL1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Pax-4a
  • Sp1
  • STAT5B

Genomic Locations for TTC36 Gene

Latest Assembly
chr11:118,527,472-118,531,197
(GRCh38/hg38)
Size:
3,726 bases
Orientation:
Plus strand

Previous Assembly
chr11:118,398,189-118,401,708
(GRCh37/hg19 by Entrez Gene)
Size:
3,520 bases
Orientation:
Plus strand

chr11:118,398,187-118,401,912
(GRCh37/hg19 by Ensembl)
Size:
3,726 bases
Orientation:
Plus strand

Genomic View for TTC36 Gene

Genes around TTC36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC36 Gene

Proteins for TTC36 Gene

  • Protein details for TTC36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLP5-TTC36_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 36
    Protein Accession:
    A6NLP5
    Secondary Accessions:
    • B7ZW72
    • B9EJD8

    Protein attributes for TTC36 Gene

    Size:
    189 amino acids
    Molecular mass:
    20896 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC36 Gene

Post-translational modifications for TTC36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC36 Gene

No data available for DME Specific Peptides for TTC36 Gene

Domains & Families for TTC36 Gene

Gene Families for TTC36 Gene

Protein Domains for TTC36 Gene

Suggested Antigen Peptide Sequences for TTC36 Gene

GenScript: Design optimal peptide antigens:
  • HSP70-binding protein 21 (TTC36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NLP5

UniProtKB/Swiss-Prot:

TTC36_HUMAN :
  • Belongs to the TTC36 family.
Family:
  • Belongs to the TTC36 family.
genes like me logo Genes that share domains with TTC36: view

Function for TTC36 Gene

Phenotypes From GWAS Catalog for TTC36 Gene

Gene Ontology (GO) - Molecular Function for TTC36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC36: view

Phenotypes for TTC36 Gene

MGI mutant phenotypes for TTC36:
inferred from 1 alleles
GenomeRNAi human phenotypes for TTC36:
genes like me logo Genes that share phenotypes with TTC36: view

miRNA for TTC36 Gene

miRTarBase miRNAs that target TTC36

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC36

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC36 Gene

Localization for TTC36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC36 gene
Compartment Confidence
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC36 Gene

Pathways & Interactions for TTC36 Gene

PathCards logo

SuperPathways for TTC36 Gene

No Data Available

Interacting Proteins for TTC36 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000307640 A6NLP5-TTC36_HUMAN for TTC36 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TTC36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006570 tyrosine metabolic process IEA --
GO:0007613 memory IEA --
GO:0008542 visual learning IEA --
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IEA --
GO:0021954 central nervous system neuron development IEA --
genes like me logo Genes that share ontologies with TTC36: view

No data available for Pathways by source and SIGNOR curated interactions for TTC36 Gene

Drugs & Compounds for TTC36 Gene

No Compound Related Data Available

Transcripts for TTC36 Gene

mRNA/cDNA for TTC36 Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC36

Alternative Splicing Database (ASD) splice patterns (SP) for TTC36 Gene

No ASD Table

Relevant External Links for TTC36 Gene

GeneLoc Exon Structure for
TTC36

Expression for TTC36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC36 Gene

This gene is overexpressed in Liver (x39.5) and Kidney - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TTC36 Gene

This gene is overexpressed in Liver, secretome (31.6), Gallbladder (18.3), and Serum (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC36 Gene



Protein tissue co-expression partners for TTC36 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC36

SOURCE GeneReport for Unigene cluster for TTC36 Gene:

Hs.653449

Evidence on tissue expression from TISSUES for TTC36 Gene

  • Liver(4.5)
genes like me logo Genes that share expression patterns with TTC36: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC36 Gene

Orthologs for TTC36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC36 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TTC36 29 30
  • 89.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC36 29 30
  • 88.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttc36 29 16 30
  • 86.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc36 29
  • 86.02 (n)
Oppossum
(Monodelphis domestica)
Mammalia TTC36 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTC36 30
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TTC36 29 30
  • 72.34 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc36 29
  • 60.61 (n)
Zebrafish
(Danio rerio)
Actinopterygii ttc36 29 30
  • 61.78 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.267 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG14105 29 30
  • 48.48 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010928 29
  • 48.19 (n)
Worm
(Caenorhabditis elegans)
Secernentea F52H3.5 29 30
  • 47.08 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToOne
Species where no ortholog for TTC36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TTC36 Gene

ENSEMBL:
Gene Tree for TTC36 (if available)
TreeFam:
Gene Tree for TTC36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC36: view image
Alliance of Genome Resources:
Additional Orthologs for TTC36

Paralogs for TTC36 Gene

No data available for Paralogs for TTC36 Gene

Variants for TTC36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC36 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs7111428 -- p.Ile78Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TTC36 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TTC36 Gene

Variant ID Type Subtype PubMed ID
esv3627872 CNV gain 21293372
nsv1044281 CNV gain 25217958

Variation tolerance for TTC36 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC36
Leiden Open Variation Database (LOVD)
TTC36

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC36 Gene

Disorders for TTC36 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TTC36 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tyrosinemia, type iii
  • tyrsn3
tyrosinemia
  • hereditary tyrosinemia
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search TTC36 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTC36

genes like me logo Genes that share disorders with TTC36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC36 Gene

Publications for TTC36 Gene

  1. HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. (PMID: 31537781) Xie Y … Zhou Q (Nature communications 2019) 3
  2. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. (PMID: 26246424) Jiang L … Guan XY (Carcinogenesis 2015) 3
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TTC36 Gene

Sources for TTC36 Gene