Aliases for TTC34 Gene

Aliases for TTC34 Gene

  • Tetratricopeptide Repeat Domain 34 2 3 5
  • Tetratricopeptide Repeat Protein 34 3 4
  • TPR Repeat Protein 34 3 4
  • TPR Repeat-Containing Protein ENSP00000383873 3
  • TTC34 5

External Ids for TTC34 Gene

Previous GeneCards Identifiers for TTC34 Gene

  • GC01M002689
  • GC01M002567
  • GC01M001993

Summaries for TTC34 Gene

GeneCards Summary for TTC34 Gene

TTC34 (Tetratricopeptide Repeat Domain 34) is a Protein Coding gene. An important paralog of this gene is TMTC2.

Additional gene information for TTC34 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC34 Gene

Genomics for TTC34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J002801 Enhancer 0.7 Ensembl 600.7 +0.0 8 0.6 CTCF FOXA1 RFX1 PATZ1 REST ZNF341 EGR1 CTBP1 RUNX3 FOXK2 TTC34 lnc-TTC34-7 piR-31462-001 MMEL1
GH01J003618 Promoter/Enhancer 1.1 EPDnew ENCODE 4.6 -817.7 -817675 0.7 GATAD2A CTCF ZNF629 JUND FOXA1 ZIC2 PKNOX1 PATZ1 REST RAD21 TPRG1L WRAP73 LRRC47 TTC34 MEGF6 LOC105378607 ARHGEF16
GH01J002821 Enhancer 0.7 Ensembl CraniofacialAtlas 0.4 -20.4 -20384 0.6 CTCF ZIC2 PATZ1 RAD21 SMC3 SAFB KLF17 ZNF654 KLF14 TRIM22 ENSG00000231630 Hsa-Mir-574_5p-001 TTC34 ACTRT2
GH01J002786 Enhancer 0.5 Ensembl 0.4 +14.9 14915 0.5 CTCF ZNF692 REST RAD21 SMC3 ZFP69B ZNF654 ZBTB7A TRIM22 PRXL2B piR-31462-001 TTC34 MMEL1
GH01J002640 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas 0.1 +159.1 159100 2.5 SP1 HNRNPL PRDM10 RFX1 ZNF692 JUND LARP7 ZIC2 RBFOX2 RXRB MMEL1 ACTRT2 PRXL2B MORN1 PANK4 lnc-TTC34-5 AB372589-001 TTC34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC34

Genomic Locations for TTC34 Gene

Genomic Locations for TTC34 Gene
chr1:2,635,976-2,801,717
(GRCh38/hg38)
Size:
165,742 bases
Orientation:
Minus strand
chr1:2,567,415-2,718,286
(GRCh37/hg19)
Size:
150,872 bases
Orientation:
Minus strand

Genomic View for TTC34 Gene

Genes around TTC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC34 Gene

Proteins for TTC34 Gene

  • Protein details for TTC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYJ7-TTC34_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 34
    Protein Accession:
    A8MYJ7
    Secondary Accessions:
    • A8MXL8

    Protein attributes for TTC34 Gene

    Size:
    566 amino acids
    Molecular mass:
    60903 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC34 Gene

Post-translational modifications for TTC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC34 Gene

Domains & Families for TTC34 Gene

Gene Families for TTC34 Gene

Protein Domains for TTC34 Gene

Suggested Antigen Peptide Sequences for TTC34 Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 34 (TTC34_HUMAN)
genes like me logo Genes that share domains with TTC34: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC34 Gene

Function for TTC34 Gene

Phenotypes From GWAS Catalog for TTC34 Gene

Gene Ontology (GO) - Molecular Function for TTC34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC34: view
genes like me logo Genes that share phenotypes with TTC34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC34 Gene

Localization for TTC34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC34 gene
Compartment Confidence
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TTC34 Gene

Pathways & Interactions for TTC34 Gene

PathCards logo

SuperPathways for TTC34 Gene

No Data Available

Interacting Proteins for TTC34 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000383873 A8MYJ7-TTC34_HUMAN for TTC34 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TTC34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC34 Gene

Drugs & Compounds for TTC34 Gene

No Compound Related Data Available

Transcripts for TTC34 Gene

mRNA/cDNA for TTC34 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC34

Alternative Splicing Database (ASD) splice patterns (SP) for TTC34 Gene

No ASD Table

Relevant External Links for TTC34 Gene

GeneLoc Exon Structure for
TTC34

Expression for TTC34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC34 Gene

mRNA differential expression in normal tissues according to GTEx for TTC34 Gene

This gene is overexpressed in Testis (x12.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC34

SOURCE GeneReport for Unigene cluster for TTC34 Gene:

Hs.632363
genes like me logo Genes that share expression patterns with TTC34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC34 Gene

Orthologs for TTC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC34 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC34 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC34 30 31
  • 81.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TTC34 30 31
  • 79.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc34 30
  • 75.27 (n)
Mouse
(Mus musculus)
Mammalia Ttc34 30 17 31
  • 74.49 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 58 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia TTC34 31
  • 31 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TTC34 31
  • 46 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC34 31
  • 33 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii TTC34 31
  • 41 (a)
OneToOne
Species where no ortholog for TTC34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTC34 Gene

ENSEMBL:
Gene Tree for TTC34 (if available)
TreeFam:
Gene Tree for TTC34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC34: view image

Paralogs for TTC34 Gene

Pseudogenes.org Pseudogenes for TTC34 Gene

genes like me logo Genes that share paralogs with TTC34: view

Variants for TTC34 Gene

Additional dbSNP identifiers (rs#s) for TTC34 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC34 Gene

Variant ID Type Subtype PubMed ID
dgv11n100 CNV gain 25217958
dgv16n106 CNV duplication 24896259
dgv17n106 CNV deletion 24896259
dgv1e215 CNV deletion 23714750
dgv1n6 CNV deletion 16902084
dgv20e59 CNV duplication 20981092
dgv21e59 CNV duplication 20981092
dgv4e199 CNV deletion 23128226
dgv51n54 CNV loss 21841781
dgv5e199 CNV deletion 23128226
esv1001627 CNV deletion 20482838
esv1006680 CNV deletion 20482838
esv1068112 CNV insertion 17803354
esv1095177 CNV insertion 17803354
esv1125194 CNV deletion 17803354
esv1134902 CNV deletion 17803354
esv1159004 CNV insertion 17803354
esv1162144 CNV deletion 17803354
esv1286791 CNV deletion 17803354
esv1312498 CNV deletion 17803354
esv1348726 CNV insertion 17803354
esv1366162 CNV deletion 17803354
esv1381913 CNV insertion 17803354
esv1394797 CNV deletion 17803354
esv1460747 CNV deletion 17803354
esv1701153 CNV deletion 17803354
esv1779754 CNV insertion 17803354
esv1780740 CNV deletion 17803354
esv1995006 CNV deletion 18987734
esv21805 CNV gain+loss 19812545
esv23086 CNV gain+loss 19812545
esv2661153 CNV deletion 23128226
esv2663943 CNV deletion 23128226
esv2672332 CNV deletion 23128226
esv3583359 CNV gain 25503493
esv3585031 CNV gain 21293372
esv3585032 CNV loss 21293372
esv3892858 CNV gain 25118596
esv6481 CNV loss 19470904
esv6961 CNV loss 19470904
esv8624 CNV loss 19470904
esv989273 CNV deletion 20482838
esv990905 CNV deletion 20482838
esv992616 CNV deletion 20482838
esv993173 CNV deletion 20482838
esv994553 CNV insertion 20482838
esv997173 CNV deletion 20482838
esv999533 CNV deletion 20482838
esv999575 CNV deletion 20482838
nsv1075768 CNV duplication 25765185
nsv1076882 CNV deletion 25765185
nsv1077280 CNV duplication 25765185
nsv1115330 CNV duplication 24896259
nsv1116582 CNV tandem duplication 24896259
nsv1116583 CNV tandem duplication 24896259
nsv1122282 CNV deletion 24896259
nsv1122283 CNV deletion 24896259
nsv1128583 CNV duplication 24896259
nsv1133124 CNV tandem duplication 24896259
nsv1137717 CNV deletion 24896259
nsv1142047 CNV tandem duplication 24896259
nsv1149955 CNV duplication 26484159
nsv1151032 CNV deletion 26484159
nsv1151057 CNV duplication 26484159
nsv159137 CNV deletion 16902084
nsv159383 CNV deletion 16902084
nsv159461 CNV deletion 16902084
nsv159584 CNV deletion 16902084
nsv159794 CNV deletion 16902084
nsv159997 CNV deletion 16902084
nsv160000 CNV deletion 16902084
nsv160029 CNV deletion 16902084
nsv160053 CNV insertion 16902084
nsv160247 CNV deletion 16902084
nsv160272 CNV deletion 16902084
nsv160294 CNV deletion 16902084
nsv160341 CNV deletion 16902084
nsv160689 CNV deletion 16902084
nsv160877 CNV deletion 16902084
nsv160879 CNV deletion 16902084
nsv160953 CNV deletion 16902084
nsv161117 CNV deletion 16902084
nsv428399 CNV gain 18775914
nsv470684 CNV loss 18288195
nsv545083 CNV gain 21841781
nsv545084 CNV loss 21841781
nsv545085 CNV gain 21841781
nsv545086 CNV loss 21841781
nsv545092 CNV gain 21841781
nsv545093 CNV gain 21841781
nsv545094 CNV gain 21841781
nsv5853 CNV insertion 18451855
nsv6964 CNV insertion 18451855
nsv7534 CNV insertion 18451855
nsv820462 CNV duplication 20802225
nsv821258 CNV duplication 20802225
nsv824586 CNV gain 20364138
nsv951028 CNV duplication 24416366
nsv951593 CNV deletion 24416366

Variation tolerance for TTC34 Gene

Gene Damage Index Score: 3.27; 52.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC34 Gene

Disorders for TTC34 Gene

Additional Disease Information for TTC34

No disorders were found for TTC34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC34 Gene

Publications for TTC34 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3

Products for TTC34 Gene

Sources for TTC34 Gene