Aliases for TTC33 Gene

Aliases for TTC33 Gene

  • Tetratricopeptide Repeat Domain 33 2 3 5
  • Tetratricopeptide Repeat Protein 33 3 4
  • Osmosis Responsive Factor 2 3
  • TPR Repeat Protein 33 3 4
  • Osmosis-Responsive Factor 4
  • OSRF 3

External Ids for TTC33 Gene

Previous GeneCards Identifiers for TTC33 Gene

  • GC05M040751
  • GC05M040663
  • GC05M040713
  • GC05M040715

Summaries for TTC33 Gene

GeneCards Summary for TTC33 Gene

TTC33 (Tetratricopeptide Repeat Domain 33) is a Protein Coding gene. Diseases associated with TTC33 include Mixed Fibrolamellar Hepatocellular Carcinoma.

Additional gene information for TTC33 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC33 Gene

Genomics for TTC33 Gene

GeneHancer (GH) Regulatory Elements for TTC33 Gene

Promoters and enhancers for TTC33 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC33 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC33

Top Transcription factor binding sites by QIAGEN in the TTC33 gene promoter:
  • C/EBPbeta
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • TBP
  • TFIID

Genomic Locations for TTC33 Gene

Genomic Locations for TTC33 Gene
chr5:40,512,333-40,755,970
(GRCh38/hg38)
Size:
243,638 bases
Orientation:
Minus strand
chr5:40,711,678-40,756,077
(GRCh37/hg19)
Size:
44,400 bases
Orientation:
Minus strand

Genomic View for TTC33 Gene

Genes around TTC33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC33 Gene

Proteins for TTC33 Gene

  • Protein details for TTC33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PID6-TTC33_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 33
    Protein Accession:
    Q6PID6
    Secondary Accessions:
    • B2R6G0
    • O95105

    Protein attributes for TTC33 Gene

    Size:
    262 amino acids
    Molecular mass:
    29411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC33 Gene

Post-translational modifications for TTC33 Gene

  • Ubiquitination at Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC33 Gene

No data available for DME Specific Peptides for TTC33 Gene

Domains & Families for TTC33 Gene

Gene Families for TTC33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TTC33 Gene

Suggested Antigen Peptide Sequences for TTC33 Gene

GenScript: Design optimal peptide antigens:
  • Osmosis-responsive factor (TTC33_HUMAN)
genes like me logo Genes that share domains with TTC33: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC33 Gene

Function for TTC33 Gene

Phenotypes From GWAS Catalog for TTC33 Gene

Gene Ontology (GO) - Molecular Function for TTC33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC33: view
genes like me logo Genes that share phenotypes with TTC33: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC33 Gene

Localization for TTC33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC33 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC33 Gene

Pathways & Interactions for TTC33 Gene

PathCards logo

SuperPathways for TTC33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC33 Gene

Drugs & Compounds for TTC33 Gene

No Compound Related Data Available

Transcripts for TTC33 Gene

mRNA/cDNA for TTC33 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC33 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for TTC33 Gene

GeneLoc Exon Structure for
TTC33

Expression for TTC33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC33 Gene

Protein differential expression in normal tissues from HIPED for TTC33 Gene

This gene is overexpressed in Platelet (32.6), Pancreas (19.8), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC33 Gene



Protein tissue co-expression partners for TTC33 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC33

SOURCE GeneReport for Unigene cluster for TTC33 Gene:

Hs.348915

Evidence on tissue expression from TISSUES for TTC33 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with TTC33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC33 Gene

Orthologs for TTC33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC33 31 30
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TTC33 31 30
  • 91.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TTC33 31 30
  • 91.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC33 31
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc33 30
  • 83.46 (n)
mouse
(Mus musculus)
Mammalia Ttc33 17 31 30
  • 81.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC33 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC33 31 30
  • 78.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC33 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc33 30
  • 63.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14643 30
zebrafish
(Danio rerio)
Actinopterygii ttc33 31 30
  • 60.15 (n)
OneToOne
Species where no ortholog for TTC33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC33 Gene

ENSEMBL:
Gene Tree for TTC33 (if available)
TreeFam:
Gene Tree for TTC33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC33: view image

Paralogs for TTC33 Gene

No data available for Paralogs for TTC33 Gene

Variants for TTC33 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC33 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs837105 - p.Leu69Met

Additional dbSNP identifiers (rs#s) for TTC33 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC33 Gene

Variant ID Type Subtype PubMed ID
esv2668589 CNV deletion 23128226
esv2730119 CNV deletion 23290073
esv3604823 CNV loss 21293372

Variation tolerance for TTC33 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC33

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC33 Gene

Disorders for TTC33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed fibrolamellar hepatocellular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TTC33 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTC33

genes like me logo Genes that share disorders with TTC33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC33 Gene

Publications for TTC33 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 54
  4. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for TTC33 Gene

Sources for TTC33 Gene