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Aliases for TTC33 Gene

Aliases for TTC33 Gene

  • Tetratricopeptide Repeat Domain 33 2 3 5
  • Osmosis Responsive Factor 2 3
  • TPR Repeat Protein 33 3 4
  • Tetratricopeptide Repeat Protein 33 3
  • Osmosis-Responsive Factor 4
  • OSRF 3

External Ids for TTC33 Gene

Previous GeneCards Identifiers for TTC33 Gene

  • GC05M040751
  • GC05M040663
  • GC05M040713
  • GC05M040715

Summaries for TTC33 Gene

GeneCards Summary for TTC33 Gene

TTC33 (Tetratricopeptide Repeat Domain 33) is a Protein Coding gene.

Additional gene information for TTC33 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC33 Gene

Genomics for TTC33 Gene

GeneHancer (GH) Regulatory Elements for TTC33 Gene

Promoters and enhancers for TTC33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I040754 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 556.8 +0.7 668 2.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC TTC33 PRKAA1 CARD6 PTGER4 GC05M040716
GH05I040832 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.3 -78.5 -78504 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC05M040833 RPL37 SNORD72 PRKAA1 CARD6 TTC33 PLCXD3
GH05I040674 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.3 +73.6 73559 15.8 ATF1 PKNOX1 SIN3A FEZF1 ZNF2 BRCA1 YY1 GLIS2 ARID2 ZNF143 PTGER4 CARD6 TTC33 PRKAA1 LOC105374738 GC05M040716
GH05I040733 Enhancer 0.9 Ensembl ENCODE 17.5 +21.1 21061 3.3 CTCF JUN ZBTB40 RAD21 RFX5 YY1 ZNF143 SMC3 FOS ZNF654 TTC33 PTGER4 CARD6 GC05M040716
GH05I040795 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 6.2 -41.9 -41902 5 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZNF213 PRKAA1 CARD6 TTC33 ENSG00000212567 GC05M040791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC33 gene promoter:

Genomic Locations for TTC33 Gene

Genomic Locations for TTC33 Gene
chr5:40,512,333-40,755,975
(GRCh38/hg38)
Size:
243,643 bases
Orientation:
Minus strand
chr5:40,711,678-40,756,077
(GRCh37/hg19)

Genomic View for TTC33 Gene

Genes around TTC33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC33 Gene

Proteins for TTC33 Gene

  • Protein details for TTC33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PID6-TTC33_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 33
    Protein Accession:
    Q6PID6
    Secondary Accessions:
    • B2R6G0
    • O95105

    Protein attributes for TTC33 Gene

    Size:
    262 amino acids
    Molecular mass:
    29411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC33 Gene

Post-translational modifications for TTC33 Gene

Other Protein References for TTC33 Gene

No data available for DME Specific Peptides for TTC33 Gene

Domains & Families for TTC33 Gene

Gene Families for TTC33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TTC33 Gene

Suggested Antigen Peptide Sequences for TTC33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC33: view

No data available for UniProtKB/Swiss-Prot for TTC33 Gene

Function for TTC33 Gene

Phenotypes From GWAS Catalog for TTC33 Gene

Gene Ontology (GO) - Molecular Function for TTC33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC33: view
genes like me logo Genes that share phenotypes with TTC33: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC33 Gene

Localization for TTC33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC33 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC33 Gene

Pathways & Interactions for TTC33 Gene

SuperPathways for TTC33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC33 Gene

Drugs & Compounds for TTC33 Gene

No Compound Related Data Available

Transcripts for TTC33 Gene

mRNA/cDNA for TTC33 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC33 Gene

Tetratricopeptide repeat domain 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC33 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for TTC33 Gene

GeneLoc Exon Structure for
TTC33
ECgene alternative splicing isoforms for
TTC33

Expression for TTC33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC33 Gene

Protein differential expression in normal tissues from HIPED for TTC33 Gene

This gene is overexpressed in Platelet (32.6), Pancreas (19.8), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC33 Gene



Protein tissue co-expression partners for TTC33 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC33 Gene:

TTC33

SOURCE GeneReport for Unigene cluster for TTC33 Gene:

Hs.348915

Evidence on tissue expression from TISSUES for TTC33 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with TTC33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC33 Gene

Orthologs for TTC33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC33 33 34
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia TTC33 33 34
  • 91.98 (n)
dog
(Canis familiaris)
Mammalia TTC33 33 34
  • 91.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC33 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc33 33
  • 83.46 (n)
mouse
(Mus musculus)
Mammalia Ttc33 33 16 34
  • 81.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC33 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC33 33 34
  • 78.16 (n)
lizard
(Anolis carolinensis)
Reptilia TTC33 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc33 33
  • 63.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14643 33
zebrafish
(Danio rerio)
Actinopterygii ttc33 33 34
  • 60.15 (n)
Species where no ortholog for TTC33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC33 Gene

ENSEMBL:
Gene Tree for TTC33 (if available)
TreeFam:
Gene Tree for TTC33 (if available)

Paralogs for TTC33 Gene

No data available for Paralogs for TTC33 Gene

Variants for TTC33 Gene

Sequence variations from dbSNP and Humsavar for TTC33 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000036683 -- 40,748,259(-) C/T intron_variant
rs1000106105 -- 40,742,199(-) T/G intron_variant
rs1000154750 -- 40,741,137(-) T/A intron_variant
rs1000178110 -- 40,713,726(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000207940 -- 40,738,801(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC33 Gene

Variant ID Type Subtype PubMed ID
esv3604823 CNV loss 21293372
esv2730119 CNV deletion 23290073
esv2668589 CNV deletion 23128226

Variation tolerance for TTC33 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC33 Gene

Disorders for TTC33 Gene

Additional Disease Information for TTC33

No disorders were found for TTC33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC33 Gene

Publications for TTC33 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for TTC33 Gene

Sources for TTC33 Gene

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