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Aliases for TTC32 Gene

Aliases for TTC32 Gene

  • Tetratricopeptide Repeat Domain 32 2 3 5
  • TPR Repeat Protein 32 4

External Ids for TTC32 Gene

Previous GeneCards Identifiers for TTC32 Gene

  • GC02M019959
  • GC02M020096

Summaries for TTC32 Gene

GeneCards Summary for TTC32 Gene

TTC32 (Tetratricopeptide Repeat Domain 32) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding.

Additional gene information for TTC32 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC32 Gene

Genomics for TTC32 Gene

GeneHancer (GH) Regulatory Elements for TTC32 Gene

Promoters and enhancers for TTC32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I019899 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 594.3 +0.4 375 3.6 CLOCK DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 SSRP1 ZNF610 TTC32 ENSG00000271991 MATN3 LINC00954 PUM2 WDR35
GH02I019903 Enhancer 0.5 ENCODE dbSUPER 550.8 -1.6 -1649 0.2 ZBTB33 TTC32 ENSG00000271991 MATN3 GC02P019954
GH02I020065 Enhancer 1.3 Ensembl ENCODE dbSUPER 62.8 -164.0 -163999 1.9 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 FOS SP5 ZNF662 TTC32 WDR35 LINC01376 PUM2 MATN3 ENSG00000234378 LOC105373463 GC02M020086
GH02I019988 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34.1 -88.0 -88048 2.2 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 WDR35 LOC101928222 TTC32 MATN3 RNFT1P1
GH02I020166 Enhancer 1.3 Ensembl ENCODE dbSUPER 41.1 -264.6 -264646 2 HDGF ARNT ZNF493 ZNF133 YBX1 TCF12 ZNF548 FOS RUNX3 ZNF202 PUM2 TTC32 MATN3 WDR35 LINC00954 LINC01376 SDC1 LAPTM4A GC02M020159 GC02P020178
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC32 gene promoter:

Genomic Locations for TTC32 Gene

Genomic Locations for TTC32 Gene
chr2:19,896,643-19,901,986
(GRCh38/hg38)
Size:
5,344 bases
Orientation:
Minus strand
chr2:20,096,404-20,101,747
(GRCh37/hg19)

Genomic View for TTC32 Gene

Genes around TTC32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC32 Gene

Proteins for TTC32 Gene

  • Protein details for TTC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5I0X7-TTC32_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 32
    Protein Accession:
    Q5I0X7

    Protein attributes for TTC32 Gene

    Size:
    151 amino acids
    Molecular mass:
    17296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC32 Gene

Post-translational modifications for TTC32 Gene

No Post-translational modifications

Other Protein References for TTC32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC32 Gene

Domains & Families for TTC32 Gene

Gene Families for TTC32 Gene

Protein Domains for TTC32 Gene

Suggested Antigen Peptide Sequences for TTC32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC32: view

No data available for UniProtKB/Swiss-Prot for TTC32 Gene

Function for TTC32 Gene

Phenotypes From GWAS Catalog for TTC32 Gene

Gene Ontology (GO) - Molecular Function for TTC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC32: view
genes like me logo Genes that share phenotypes with TTC32: view

miRNA for TTC32 Gene

miRTarBase miRNAs that target TTC32

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC32 Gene

Localization for TTC32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC32 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC32 Gene

Pathways & Interactions for TTC32 Gene

SuperPathways for TTC32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC32 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC32 Gene

Drugs & Compounds for TTC32 Gene

No Compound Related Data Available

Transcripts for TTC32 Gene

mRNA/cDNA for TTC32 Gene

Unigene Clusters for TTC32 Gene

Tetratricopeptide repeat domain 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC32 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for TTC32 Gene

GeneLoc Exon Structure for
TTC32
ECgene alternative splicing isoforms for
TTC32

Expression for TTC32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC32 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC32 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC32 Gene:

TTC32

SOURCE GeneReport for Unigene cluster for TTC32 Gene:

Hs.591547

Evidence on tissue expression from TISSUES for TTC32 Gene

  • Eye(4.8)
  • Skin(3.4)
genes like me logo Genes that share expression patterns with TTC32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC32 Gene

Orthologs for TTC32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC32 33 34
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia TTC32 33 34
  • 89.27 (n)
dog
(Canis familiaris)
Mammalia TTC32 33 34
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Ttc32 33 16 34
  • 82.85 (n)
rat
(Rattus norvegicus)
Mammalia Ttc32 33
  • 81.56 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC32 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC32 33 34
  • 63.98 (n)
lizard
(Anolis carolinensis)
Reptilia TTC32 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc32 33
  • 63.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33815 33
zebrafish
(Danio rerio)
Actinopterygii ttc32 33 34
  • 63.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2870 33
Species where no ortholog for TTC32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC32 Gene

ENSEMBL:
Gene Tree for TTC32 (if available)
TreeFam:
Gene Tree for TTC32 (if available)

Paralogs for TTC32 Gene

No data available for Paralogs for TTC32 Gene

Variants for TTC32 Gene

Sequence variations from dbSNP and Humsavar for TTC32 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000167483 -- 19,897,584(-) C/G intron_variant
rs1000486709 -- 19,903,745(-) A/G upstream_transcript_variant
rs1000732187 -- 19,903,447(-) C/T upstream_transcript_variant
rs1000994132 -- 19,901,927(-) C/T 5_prime_UTR_variant
rs1001222310 -- 19,902,163(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC32 Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV loss 17803354
nsv521619 CNV loss 19592680
nsv522640 CNV loss 19592680

Variation tolerance for TTC32 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC32 Gene

Disorders for TTC32 Gene

Additional Disease Information for TTC32

No disorders were found for TTC32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC32 Gene

Publications for TTC32 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  4. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. (PMID: 22751097) Lu X … Gu D (Nature genetics 2012) 3 58
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58

Products for TTC32 Gene

Sources for TTC32 Gene

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