Aliases for TTC31 Gene

Aliases for TTC31 Gene

  • Tetratricopeptide Repeat Domain 31 2 3 5
  • Tetratricopeptide Repeat Protein 31 3 4
  • TPR Repeat Protein 31 3 4
  • FLJ12788 2
  • TTC31 5

External Ids for TTC31 Gene

Previous GeneCards Identifiers for TTC31 Gene

  • GC02P074564
  • GC02P074710
  • GC02P074446

Summaries for TTC31 Gene

GeneCards Summary for TTC31 Gene

TTC31 (Tetratricopeptide Repeat Domain 31) is a Protein Coding gene. An important paralog of this gene is SPAG1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC31 Gene

Genomics for TTC31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC31 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC31

Top Transcription factor binding sites by QIAGEN in the TTC31 gene promoter:
  • Elk-1
  • ER-alpha
  • GCNF
  • GCNF-1
  • GCNF-2
  • MyoD
  • NF-1
  • NF-1/L
  • Olf-1
  • Pax-6

Genomic Locations for TTC31 Gene

Latest Assembly
chr2:74,483,073-74,494,559
(GRCh38/hg38)
Size:
11,487 bases
Orientation:
Plus strand

Previous Assembly
chr2:74,710,208-74,721,686
(GRCh37/hg19 by Entrez Gene)
Size:
11,479 bases
Orientation:
Plus strand

chr2:74,710,200-74,722,013
(GRCh37/hg19 by Ensembl)
Size:
11,814 bases
Orientation:
Plus strand

Genomic View for TTC31 Gene

Genes around TTC31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC31 Gene

Proteins for TTC31 Gene

  • Protein details for TTC31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AM3-TTC31_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 31
    Protein Accession:
    Q49AM3
    Secondary Accessions:
    • Q4KN40
    • Q53FD4
    • Q9H9F7

    Protein attributes for TTC31 Gene

    Size:
    519 amino acids
    Molecular mass:
    57105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC31 Gene

Post-translational modifications for TTC31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC31 Gene

Domains & Families for TTC31 Gene

Gene Families for TTC31 Gene

Protein Domains for TTC31 Gene

Suggested Antigen Peptide Sequences for TTC31 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57634 (B4DWL4_HUMAN)
  • cDNA FLJ57684 (B4DZV1_HUMAN)
  • FLJ12788 protein (Q4KMS4_HUMAN)
  • TTC31 protein (Q86XF2_HUMAN)
  • Tetratricopeptide repeat protein 31 (TTC31_HUMAN)
genes like me logo Genes that share domains with TTC31: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC31 Gene

Function for TTC31 Gene

Phenotypes From GWAS Catalog for TTC31 Gene

Gene Ontology (GO) - Molecular Function for TTC31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC31: view
genes like me logo Genes that share phenotypes with TTC31: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC31

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC31 Gene

Localization for TTC31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC31 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC31 Gene

Pathways & Interactions for TTC31 Gene

PathCards logo

SuperPathways for TTC31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC31 Gene

Drugs & Compounds for TTC31 Gene

No Compound Related Data Available

Transcripts for TTC31 Gene

mRNA/cDNA for TTC31 Gene

15 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC31

Alternative Splicing Database (ASD) splice patterns (SP) for TTC31 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - -
SP10: -
SP11: - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16:

ExUns: 14a · 14b · 14c · 14d · 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TTC31 Gene

GeneLoc Exon Structure for
TTC31

Expression for TTC31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC31 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC31 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC31

SOURCE GeneReport for Unigene cluster for TTC31 Gene:

Hs.557709
genes like me logo Genes that share expression patterns with TTC31: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC31 Gene

Orthologs for TTC31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC31 29 30
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC31 29 30
  • 82 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTC31 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TTC31 30
  • 21 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC31 30
  • 39 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii TTC31 30
  • 19 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 30
  • 10 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 14 (a)
OneToOne
Species where no ortholog for TTC31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTC31 Gene

ENSEMBL:
Gene Tree for TTC31 (if available)
TreeFam:
Gene Tree for TTC31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC31: view image
Alliance of Genome Resources:
Additional Orthologs for TTC31

Paralogs for TTC31 Gene

(1) SIMAP similar genes for TTC31 Gene using alignment to 5 proteins:

  • TTC31_HUMAN
  • B4DZV1_HUMAN
  • G5E9H3_HUMAN
  • H7BZ54_HUMAN
  • Q86XF2_HUMAN
genes like me logo Genes that share paralogs with TTC31: view

Variants for TTC31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC31 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs35852562 -- p.Thr205Pro
rs6707475 -- p.Ala28Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TTC31 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TTC31 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv472055 CNV novel sequence insertion 20440878
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for TTC31 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC31
Leiden Open Variation Database (LOVD)
TTC31

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC31 Gene

Disorders for TTC31 Gene

Additional Disease Information for TTC31

No disorders were found for TTC31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC31 Gene

Publications for TTC31 Gene

  1. [Novel bidirectional promoter from human genome]. (PMID: 21790010) Orekhova AS … Rubtsov PM (Molekuliarnaia biologiia 2011) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. (PMID: 30995489) MacLeod G … Angers S (Cell reports 2019) 3
  5. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (PMID: 29395067) Youn JY … Gingras AC (Molecular cell 2018) 3

Products for TTC31 Gene

Sources for TTC31 Gene