Aliases for TTC3 Gene

Aliases for TTC3 Gene

  • Tetratricopeptide Repeat Domain 3 2 3 5
  • RNF105 2 3 4
  • DCRR1 2 3 4
  • RING-Type E3 Ubiquitin Transferase TTC3 3 4
  • Tetratricopeptide Repeat Protein 3 3 4
  • E3 Ubiquitin-Protein Ligase TTC3 3 4
  • RING Finger Protein 105 3 4
  • TPR Repeat Protein 3 3 4
  • TPR Repeat Protein D 3 4
  • TPRDIII 2 3
  • TPRD 2 4
  • Protein DCRR1 4
  • EC 2.3.2.27 4
  • TPRDII 2
  • TPRDI 2
  • TTC3 5

External Ids for TTC3 Gene

Previous GeneCards Identifiers for TTC3 Gene

  • GC21P035035
  • GC21P037375
  • GC21P037378
  • GC21P037376
  • GC21P037367
  • GC21P038445
  • GC21P023921

Summaries for TTC3 Gene

GeneCards Summary for TTC3 Gene

TTC3 (Tetratricopeptide Repeat Domain 3) is a Protein Coding gene. Diseases associated with TTC3 include Down Syndrome and Cataract 4, Multiple Types. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot Summary for TTC3 Gene

  • E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323).

Gene Wiki entry for TTC3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC3 Gene

Genomics for TTC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J037071 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 673 +0.0 41 4.4 ARHGAP35 CREB1 GATAD2A HNRNPL PRDM10 ZNF629 ZNF512 LEF1 IKZF1 NFKBIZ TTC3 PIGP lnc-HLCS-5 SETD4 ENSG00000242553 DYRK1A MORC3 TTC3-AS1 ENSG00000270116 lnc-TTC3-4
GH21J037076 Promoter 0.4 EPDnew 600.7 +3.5 3519 0.1 ZNF362 TTC3 ENSG00000270116 lnc-TTC3-4 VPS26C
GH21J037152 Enhancer 1.1 Ensembl ENCODE 65.8 +81.0 81017 3.6 GATAD2A REST TFE3 RCOR2 ZNF7 RXRB IRF2 SP1 CEBPA FOXK2 TTC3 HLCS MRPL20P1 ENSG00000207416 ENSG00000273199 MN309174-436 piR-39858-415 L13712-020 VPS26C
GH21J037059 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 53 -11.9 -11902 3.4 CREB1 GATAD2A PRDM10 ZNF629 RFX1 ZNF692 ZNF7 JUND FOXA1 ZIC2 PIGP TTC3 MRPL20P1 ENSG00000207416 HLCS LOC105372795-001 piR-53029-077 lnc-TTC3-4 RIPPLY3
GH21J037206 Promoter/Enhancer 1.2 Ensembl ENCODE 49.1 +134.8 134833 3.1 SP1 HNRNPL GATAD2A POLR2A ZNF143 RELA ZIC2 ZNF24 REST IKZF2 DSCR9 TTC3 PIGP VPS26C TTC3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC3

Top Transcription factor binding sites by QIAGEN in the TTC3 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-kappaB1
  • Pbx1a
  • RelA

Genomic Locations for TTC3 Gene

Genomic Locations for TTC3 Gene
chr21:37,073,184-37,203,118
(GRCh38/hg38)
Size:
129,935 bases
Orientation:
Plus strand
chr21:38,445,526-38,575,413
(GRCh37/hg19)
Size:
129,888 bases
Orientation:
Plus strand

Genomic View for TTC3 Gene

Genes around TTC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC3 Gene

Proteins for TTC3 Gene

  • Protein details for TTC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53804-TTC3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TTC3
    Protein Accession:
    P53804
    Secondary Accessions:
    • A8K7H7
    • B2RPA7
    • D3DSG9
    • D3DSH2
    • D3DSH3
    • O60767
    • P78476
    • P78477
    • Q569I2
    • Q6P578
    • Q9UEK4

    Protein attributes for TTC3 Gene

    Size:
    2025 amino acids
    Molecular mass:
    229869 Da
    Quaternary structure:
    • Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated) (PubMed:20059950). Interacts with CIT (PubMed:17488780). Interacts with POLG (PubMed:29290964). Interacts with HSP70 (PubMed:29290964). Interacts with SMURF2 (PubMed:30696809).
    SequenceCaution:
    • Sequence=AAH63033.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH92466.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC3 Gene

Post-translational modifications for TTC3 Gene

  • Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.
  • Proteolytically cleaved into differently sized N- and C-terminal fragments.
  • Ubiquitination at Lys53, Lys470, Lys488, and Lys629
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC3 Gene

Domains & Families for TTC3 Gene

Gene Families for TTC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TTC3 Gene

Suggested Antigen Peptide Sequences for TTC3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59417, highly similar to Tetratricopeptide repeat protein 3 (B4DSZ9_HUMAN)
  • Hypothetical rhabdomyosarcoma antigen MU-RMS-40.11C (Q5GIT6_HUMAN)
  • Tetratricopeptide repeat protein 3 (TTC3_HUMAN)
genes like me logo Genes that share domains with TTC3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC3 Gene

Function for TTC3 Gene

Molecular function for TTC3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30696809};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by TGFB1 signaling.
GENATLAS Biochemistry:
tetratricopeptide-repeat containing gene isoform 3,on the Down syndrome critical region,predominantly expressed in the central nervous system

Enzyme Numbers (IUBMB) for TTC3 Gene

Phenotypes From GWAS Catalog for TTC3 Gene

Gene Ontology (GO) - Molecular Function for TTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA,IDA 20059950
GO:0005515 protein binding IPI 20059950
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TTC3: view
genes like me logo Genes that share phenotypes with TTC3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC3 Gene

Localization for TTC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC3 Gene

Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleavage may reveal an N-terminal nuclear localization signal, allowing N-terminal fragments to enter the nucleus (PubMed:30203323). {ECO:0000269 PubMed:30203323}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
golgi apparatus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20059950
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with TTC3: view

Pathways & Interactions for TTC3 Gene

PathCards logo

SuperPathways for TTC3 Gene

No Data Available

UniProtKB/Swiss-Prot P53804-TTC3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TTC3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for TTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA,IDA 20059950
GO:0016567 protein ubiquitination IEA --
GO:0070936 protein K48-linked ubiquitination IDA 20059950
genes like me logo Genes that share ontologies with TTC3: view

No data available for Pathways by source for TTC3 Gene

Drugs & Compounds for TTC3 Gene

No Compound Related Data Available

Transcripts for TTC3 Gene

mRNA/cDNA for TTC3 Gene

10 REFSEQ mRNAs :
38 NCBI additional mRNA sequence :
25 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC3

Alternative Splicing Database (ASD) splice patterns (SP) for TTC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - - -
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TTC3 Gene

GeneLoc Exon Structure for
TTC3

Expression for TTC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC3 Gene

Protein differential expression in normal tissues from HIPED for TTC3 Gene

This gene is overexpressed in Bone (38.3), Monocytes (13.3), Lung (8.6), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC3 Gene



Protein tissue co-expression partners for TTC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC3

SOURCE GeneReport for Unigene cluster for TTC3 Gene:

Hs.368214

mRNA Expression by UniProt/SwissProt for TTC3 Gene:

P53804-TTC3_HUMAN
Tissue specificity: Found in all tissues examined.

Evidence on tissue expression from TISSUES for TTC3 Gene

  • Nervous system(5)
  • Intestine(4.5)
  • Lung(4)
  • Eye(3.9)
  • Kidney(3.6)
  • Skin(3.4)
  • Heart(2.7)
  • Liver(2.7)
  • Blood(2.6)
  • Spleen(2.6)
  • Muscle(2.5)
  • Bone(2.4)
  • Thyroid gland(2.3)
  • Lymph node(2.3)
  • Stomach(2.2)
  • Bone marrow(2.2)
  • Adrenal gland(2.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TTC3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC3 Gene

Orthologs for TTC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC3 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC3 30 31
  • 88.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TTC3 30 31
  • 86.11 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttc3 30 17 31
  • 82.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc3 30
  • 82.21 (n)
Oppossum
(Monodelphis domestica)
Mammalia TTC3 31
  • 45 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTC3 31
  • 44 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TTC3 30 31
  • 60.23 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 50 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
-- 31
  • 16 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc3 30
  • 52.22 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100329450 30
  • 45.6 (n)
ttc3 31
  • 30 (a)
OneToOne
Species where no ortholog for TTC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTC3 Gene

ENSEMBL:
Gene Tree for TTC3 (if available)
TreeFam:
Gene Tree for TTC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC3: view image

Paralogs for TTC3 Gene

(1) SIMAP similar genes for TTC3 Gene using alignment to 10 proteins:

  • TTC3_HUMAN
  • A8MT23_HUMAN
  • B4DSZ9_HUMAN
  • E9PCE7_HUMAN
  • E9PMP8_HUMAN
  • E9PMS7_HUMAN
  • H7BZ57_HUMAN
  • H7C097_HUMAN
  • H7C3Z1_HUMAN
  • Q5GIT6_HUMAN

Pseudogenes.org Pseudogenes for TTC3 Gene

genes like me logo Genes that share paralogs with TTC3: view

No data available for Paralogs for TTC3 Gene

Variants for TTC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC3 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
709522 Benign: not provided 37,153,144(+) A/G SYNONYMOUS_VARIANT
711760 Benign: not provided 37,144,636(+) A/G SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
718381 Benign: not provided 37,126,118(+) T/C SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
718889 Benign: not provided 37,195,684(+) G/A MISSENSE_VARIANT
720826 Benign: not provided 37,197,573(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TTC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC3 Gene

Variant ID Type Subtype PubMed ID
dgv70n68 CNV gain 17160897
esv2723398 CNV deletion 23290073
esv3406011 CNV insertion 20981092
esv3575389 CNV gain 25503493
nsv1066107 CNV loss 25217958
nsv1123558 CNV deletion 24896259
nsv1136634 CNV deletion 24896259
nsv1139021 CNV deletion 24896259
nsv1139022 CNV deletion 24896259
nsv1152243 CNV duplication 26484159
nsv3510 CNV insertion 18451855
nsv3511 CNV insertion 18451855
nsv3512 CNV deletion 18451855
nsv819934 CNV gain 19587683

Variation tolerance for TTC3 Gene

Residual Variation Intolerance Score: 1.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC3 Gene

Human Gene Mutation Database (HGMD)
TTC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC3 Gene

Disorders for TTC3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TTC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • trisomy 21
cataract 4, multiple types
  • ctrct4
loeys-dietz syndrome 2
  • lds2
cataract 34, multiple types
  • ctrct34
lens disease
  • lens diseases
- elite association - COSMIC cancer census association via MalaCards
Search TTC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TTC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC3 Gene

Publications for TTC3 Gene

  1. Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2. (PMID: 8947847) Tsukahara F … Sakaki Y (Journal of biochemistry 1996) 2 3 4 23
  2. TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation. (PMID: 30696809) Kim JH … Lee YS (Cell death & disease 2019) 3 4
  3. Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase γ. (PMID: 29290964) Gong Y … Dou F (Oncotarget 2017) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Digital quantification of human eye color highlights genetic association of three new loci. (PMID: 20463881) Liu F … Kayser M (PLoS genetics 2010) 3 41

Products for TTC3 Gene

Sources for TTC3 Gene