Aliases for TTC27 Gene

Aliases for TTC27 Gene

  • Tetratricopeptide Repeat Domain 27 2 3 5
  • Tetratricopeptide Repeat Protein 27 3 4
  • TPR Repeat Protein 27 3 4

External Ids for TTC27 Gene

Previous GeneCards Identifiers for TTC27 Gene

  • GC02P032706
  • GC02P032853
  • GC02P032592

Summaries for TTC27 Gene

GeneCards Summary for TTC27 Gene

TTC27 (Tetratricopeptide Repeat Domain 27) is a Protein Coding gene.

Additional gene information for TTC27 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC27 Gene

Genomics for TTC27 Gene

GeneHancer (GH) Regulatory Elements for TTC27 Gene

Promoters and enhancers for TTC27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC27

Top Transcription factor binding sites by QIAGEN in the TTC27 gene promoter:
  • FAC1
  • IRF-2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-5
  • SEF-1 (1)
  • SRY
  • TBP
  • TFIID

Genomic Locations for TTC27 Gene

Genomic Locations for TTC27 Gene
chr2:32,628,020-32,821,051
(GRCh38/hg38)
Size:
193,032 bases
Orientation:
Plus strand
chr2:32,853,087-33,046,118
(GRCh37/hg19)
Size:
193,032 bases
Orientation:
Plus strand

Genomic View for TTC27 Gene

Genes around TTC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC27 Gene

Proteins for TTC27 Gene

  • Protein details for TTC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3X3-TTC27_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 27
    Protein Accession:
    Q6P3X3
    Secondary Accessions:
    • A6NKJ0
    • Q96SS5
    • Q9BVF1
    • Q9NWR4
    • Q9NXG4

    Protein attributes for TTC27 Gene

    Size:
    843 amino acids
    Molecular mass:
    96632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TTC27 Gene

Post-translational modifications for TTC27 Gene

  • Ubiquitination at Lys803
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC27 Gene

Domains & Families for TTC27 Gene

Gene Families for TTC27 Gene

Protein Domains for TTC27 Gene

Suggested Antigen Peptide Sequences for TTC27 Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 27 (TTC27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P3X3

UniProtKB/Swiss-Prot:

TTC27_HUMAN :
  • Belongs to the TTC27 family.
Family:
  • Belongs to the TTC27 family.
genes like me logo Genes that share domains with TTC27: view

Function for TTC27 Gene

Phenotypes From GWAS Catalog for TTC27 Gene

Gene Ontology (GO) - Molecular Function for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI,IEA 29513927
genes like me logo Genes that share ontologies with TTC27: view
genes like me logo Genes that share phenotypes with TTC27: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC27 Gene

Localization for TTC27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC27 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
cytoskeleton 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TTC27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC27 Gene

Pathways & Interactions for TTC27 Gene

PathCards logo

SuperPathways for TTC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC27: view

No data available for Pathways by source and SIGNOR curated interactions for TTC27 Gene

Drugs & Compounds for TTC27 Gene

No Compound Related Data Available

Transcripts for TTC27 Gene

mRNA/cDNA for TTC27 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC27 Gene

No ASD Table

Relevant External Links for TTC27 Gene

GeneLoc Exon Structure for
TTC27

Expression for TTC27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC27 Gene

Protein differential expression in normal tissues from HIPED for TTC27 Gene

This gene is overexpressed in Bone (31.6), Peripheral blood mononuclear cells (15.1), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC27 Gene



Protein tissue co-expression partners for TTC27 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC27

SOURCE GeneReport for Unigene cluster for TTC27 Gene:

Hs.468125

Evidence on tissue expression from TISSUES for TTC27 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TTC27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC27 Gene

Orthologs for TTC27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC27 31 30
  • 98.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TTC27 31 30
  • 90.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TTC27 31 30
  • 89.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc27 17 31 30
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Ttc27 30
  • 84.06 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC27 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC27 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC27 31 30
  • 74.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC27 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc27 30
  • 67.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24470 30
zebrafish
(Danio rerio)
Actinopterygii ttc27 31 30
  • 59.46 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5290 31 30
  • 43.44 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006358 30
  • 41.5 (n)
worm
(Caenorhabditis elegans)
Secernentea T20B12.1 31 30
  • 46.97 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL177C 30
  • 44.03 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07239g 30
  • 42.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMW1 33 31 30
  • 41.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.01 30
  • 46.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09658 30
  • 43.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToOne
Species where no ortholog for TTC27 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC27 Gene

ENSEMBL:
Gene Tree for TTC27 (if available)
TreeFam:
Gene Tree for TTC27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC27: view image

Paralogs for TTC27 Gene

No data available for Paralogs for TTC27 Gene

Variants for TTC27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC27 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs17012268 - p.Arg586His
rs2273660 - p.Tyr476Cys
rs2273664 - p.Arg525His
rs34188947 - p.Thr498Met

Additional dbSNP identifiers (rs#s) for TTC27 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC27 Gene

Variant ID Type Subtype PubMed ID
dgv1109e212 CNV gain 25503493
dgv3749n100 CNV gain 25217958
dgv3750n100 CNV gain 25217958
dgv3751n100 CNV gain 25217958
dgv3752n100 CNV gain 25217958
dgv443n27 CNV gain 19166990
dgv6750n54 CNV gain 21841781
dgv683e214 CNV loss 21293372
esv2422335 CNV duplication 17116639
esv2422472 CNV duplication 17116639
esv2652244 CNV deletion 19546169
esv2661876 CNV deletion 23128226
esv2751888 CNV gain 17911159
esv2763243 CNV gain 21179565
esv3575218 CNV gain 25503493
esv3590249 CNV gain 21293372
esv3590254 CNV gain 21293372
esv3590256 CNV gain 21293372
esv3590257 CNV loss 21293372
esv3590258 CNV loss 21293372
esv3590259 CNV loss 21293372
esv3590263 CNV loss 21293372
esv3590264 CNV gain 21293372
esv3891703 CNV gain 25118596
esv3891714 CNV gain 25118596
nsv1004912 CNV loss 25217958
nsv1005939 CNV gain 25217958
nsv1114065 CNV deletion 24896259
nsv456108 CNV gain 19166990
nsv470448 CNV gain 18288195
nsv516173 CNV gain+loss 19592680
nsv581274 CNV gain 21841781
nsv581281 CNV gain 21841781
nsv581283 CNV loss 21841781
nsv581284 CNV gain 21841781
nsv581285 CNV gain 21841781
nsv581286 CNV loss 21841781
nsv581287 CNV gain 21841781
nsv833692 CNV loss 17160897
nsv833703 CNV loss 17160897

Variation tolerance for TTC27 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.49; 88.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC27 Gene

Disorders for TTC27 Gene

Additional Disease Information for TTC27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TTC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC27 Gene

Publications for TTC27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI. (PMID: 31240132) Hu WF … Woods NT (Cell death discovery 2019) 3 54
  4. SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation. (PMID: 29969578) Xiao N … Yao M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 54
  5. Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes. (PMID: 31046837) Lee JH … Jou I (Acta neuropathologica communications 2019) 3 54

Products for TTC27 Gene

Sources for TTC27 Gene