Aliases for TTC26 Gene
External Ids for TTC26 Gene
Previous GeneCards Identifiers for TTC26 Gene
GeneCards Summary for TTC26 Gene
TTC26 (Tetratricopeptide Repeat Domain 26) is a Protein Coding gene. Diseases associated with TTC26 include Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly and Bardet-Biedl Syndrome 8. Among its related pathways are Intraflagellar transport and Organelle biogenesis and maintenance.
UniProtKB/Swiss-Prot Summary for TTC26 Gene
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.