Aliases for TTC26 Gene

Aliases for TTC26 Gene

  • Tetratricopeptide Repeat Domain 26 2 3 5
  • Intraflagellar Transport Protein 56 3 4
  • Tetratricopeptide Repeat Protein 26 3 4
  • TPR Repeat Protein 26 3 4
  • IFT56 3 4
  • Dyf-13 3
  • DYF13 3

External Ids for TTC26 Gene

Previous GeneCards Identifiers for TTC26 Gene

  • GC07P138469
  • GC07P138818
  • GC07P133128

Summaries for TTC26 Gene

GeneCards Summary for TTC26 Gene

TTC26 (Tetratricopeptide Repeat Domain 26) is a Protein Coding gene. Diseases associated with TTC26 include Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly and Bardet-Biedl Syndrome 8. Among its related pathways are Intraflagellar transport and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot Summary for TTC26 Gene

  • Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.

Additional gene information for TTC26 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC26 Gene

Genomics for TTC26 Gene

GeneHancer (GH) Regulatory Elements for TTC26 Gene

Promoters and enhancers for TTC26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J139100 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 531.6 -26.8 -26831 13.1 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G BCLAF1 NONO GTF2E2 TTC26 ZC3HAV1 UBN2 LUC7L2 ZC3HAV1L PARP12 piR-56451-096
GH07J139133 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509.1 +0.5 458 1.9 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 POLR2G SP1 NCOR1 GTF2E2 TTC26 RF00017-6676
GH07J139131 Enhancer 0.6 dbSUPER 509.3 -1.7 -1665 2.2 ZNF316 CEBPG BCOR ZFP91 ZNF146 CEBPB SPI1 HLF NFIC PRDM1 TTC26 ZC3HAV1L ZC3HAV1 lnc-ZC3HAV1-2
GH07J139339 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.1 +207.8 207838 4 RXRA FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G LUC7L2 AJ535831-005 FMC1 FMC1-LUC7L2 TRR-CCT4-1 piR-30229 UBN2 ENSG00000273391 TTC26 KLRG2
GH07J138527 Enhancer 0.9 ENCODE 26.3 -605.2 -605151 0.9 HNRNPK TCF12 POLR2G ZBTB11 AFF1 TRIM28 HES1 ZNF740 TOE1 MYC LUC7L2 TTC26 UBN2 HSALNG0061681 RF00994-1034 TRIM24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC26 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC26

Top Transcription factor binding sites by QIAGEN in the TTC26 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Evi-1
  • HSF1 (long)
  • HSF1short

Genomic Locations for TTC26 Gene

Genomic Locations for TTC26 Gene
chr7:139,133,370-139,191,986
(GRCh38/hg38)
Size:
58,617 bases
Orientation:
Plus strand
chr7:138,818,490-138,876,732
(GRCh37/hg19)
Size:
58,243 bases
Orientation:
Plus strand

Genomic View for TTC26 Gene

Genes around TTC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC26 Gene

Proteins for TTC26 Gene

  • Protein details for TTC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVF1-IFT56_HUMAN
    Recommended name:
    Intraflagellar transport protein 56
    Protein Accession:
    A0AVF1
    Secondary Accessions:
    • A4D1S3
    • B7Z5M0
    • C9J2N7
    • F8W724
    • Q9H9S8
    • Q9NTC0

    Protein attributes for TTC26 Gene

    Size:
    554 amino acids
    Molecular mass:
    64178 Da
    Quaternary structure:
    • Component of the IFT complex B. Interacts with IFT46; the interaction is direct.
    SequenceCaution:
    • Sequence=EAL24039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC26 Gene

Post-translational modifications for TTC26 Gene

  • Ubiquitination at Lys257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC26 Gene

Domains & Families for TTC26 Gene

Gene Families for TTC26 Gene

Protein Domains for TTC26 Gene

Suggested Antigen Peptide Sequences for TTC26 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60534 (B7Z2T3_HUMAN)
  • cDNA FLJ55883 (B7Z6R6_HUMAN)
  • Tetratricopeptide repeat protein 26 (TTC26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A0AVF1

UniProtKB/Swiss-Prot:

IFT56_HUMAN :
  • Belongs to the IFT56 family.
Family:
  • Belongs to the IFT56 family.
genes like me logo Genes that share domains with TTC26: view

Function for TTC26 Gene

Molecular function for TTC26 Gene

UniProtKB/Swiss-Prot Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.

Phenotypes From GWAS Catalog for TTC26 Gene

Gene Ontology (GO) - Molecular Function for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0120170 intraciliary transport particle B binding IBA 21873635
genes like me logo Genes that share ontologies with TTC26: view
genes like me logo Genes that share phenotypes with TTC26: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC26 Gene

Localization for TTC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC26 Gene

Cell projection, cilium. Note=Localizes at the base to the ciliary transition zone. {ECO:0000250 UniProtKB:Q8BS45}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC26 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2
plasma membrane 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA --
GO:0005929 cilium TAS --
GO:0030992 intraciliary transport particle B ISS,IBA --
GO:0036064 ciliary basal body IBA 21873635
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TTC26: view

Pathways & Interactions for TTC26 Gene

genes like me logo Genes that share pathways with TTC26: view

Pathways by source for TTC26 Gene

Gene Ontology (GO) - Biological Process for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway ISS --
GO:0007286 spermatid development IEA --
GO:0015031 protein transport IEA --
GO:0035082 axoneme assembly ISS --
GO:0035720 intraciliary anterograde transport IBA 21873635
genes like me logo Genes that share ontologies with TTC26: view

No data available for SIGNOR curated interactions for TTC26 Gene

Drugs & Compounds for TTC26 Gene

No Compound Related Data Available

Transcripts for TTC26 Gene

mRNA/cDNA for TTC26 Gene

9 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC26 Gene

No ASD Table

Relevant External Links for TTC26 Gene

GeneLoc Exon Structure for
TTC26

Expression for TTC26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC26 Gene

This gene is overexpressed in Testis (45.5) and Urine (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC26 Gene



Protein tissue co-expression partners for TTC26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC26

SOURCE GeneReport for Unigene cluster for TTC26 Gene:

Hs.644553

Evidence on tissue expression from TISSUES for TTC26 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TTC26: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC26 Gene

Orthologs for TTC26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC26 31 30
  • 99.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TTC26 31 30
  • 93.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TTC26 31 30
  • 93.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc26 30
  • 90.79 (n)
mouse
(Mus musculus)
Mammalia Ttc26 17 31 30
  • 90.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC26 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC26 31 30
  • 78.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC26 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc26 30
  • 77.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10313 30
zebrafish
(Danio rerio)
Actinopterygii ttc26 31 30
  • 72.44 (n)
OneToOne
Dr.14525 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2641 30
fruit fly
(Drosophila melanogaster)
Insecta CG4525 31 30
  • 58.61 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001809 30
  • 56.97 (n)
worm
(Caenorhabditis elegans)
Secernentea dyf-13 31 30
  • 49.19 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 75 (a)
OneToOne
Species where no ortholog for TTC26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC26 Gene

ENSEMBL:
Gene Tree for TTC26 (if available)
TreeFam:
Gene Tree for TTC26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC26: view image

Paralogs for TTC26 Gene

No data available for Paralogs for TTC26 Gene

Variants for TTC26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC26 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs13225917 - p.Asp310Asn

Additional dbSNP identifiers (rs#s) for TTC26 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC26 Gene

Variant ID Type Subtype PubMed ID
esv2669645 CNV deletion 23128226
esv2735212 CNV deletion 23290073
esv2759567 CNV gain 17122850
esv3368950 CNV insertion 20981092
esv3615209 CNV loss 21293372
nsv831155 CNV loss 17160897

Variation tolerance for TTC26 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC26 Gene

Disorders for TTC26 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TTC26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
short-rib thoracic dysplasia 3 with or without polydactyly
  • majewski syndrome
bardet-biedl syndrome 8
  • bbs8
short-rib thoracic dysplasia 12
  • srtd12
polycystic liver disease
  • congenital cystic liver disease
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TTC26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTC26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TTC26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC26 Gene

Publications for TTC26 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The human cytoplasmic dynein interactome reveals novel activators of motility. (PMID: 28718761) Redwine WB … Reck-Peterson SL (eLife 2017) 3 54
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 54

Products for TTC26 Gene

Sources for TTC26 Gene