Aliases for TTC23L Gene

Aliases for TTC23L Gene

  • Tetratricopeptide Repeat Domain 23 Like 2 3 5
  • Tetratricopeptide Repeat Protein 23-Like 3 4
  • Tetratricopeptide Repeat Domain 23-Like 2
  • FLJ25439 2
  • MC25-1 3
  • TTC23L 5

External Ids for TTC23L Gene

Previous GeneCards Identifiers for TTC23L Gene

  • GC05P034876
  • GC05P034840
  • GC05P034787

Summaries for TTC23L Gene

GeneCards Summary for TTC23L Gene

TTC23L (Tetratricopeptide Repeat Domain 23 Like) is a Protein Coding gene. An important paralog of this gene is TTC23.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC23L Gene

Genomics for TTC23L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC23L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC23L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC23L

Top Transcription factor binding sites by QIAGEN in the TTC23L gene promoter:
  • Arnt
  • Evi-1
  • FOXF2
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for TTC23L Gene

Genomic Locations for TTC23L Gene
chr5:34,838,833-34,900,511
(GRCh38/hg38)
Size:
61,679 bases
Orientation:
Plus strand
chr5:34,838,938-34,899,567
(GRCh37/hg19)
Size:
60,630 bases
Orientation:
Plus strand

Genomic View for TTC23L Gene

Genes around TTC23L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC23L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC23L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC23L Gene

Proteins for TTC23L Gene

  • Protein details for TTC23L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF05-TT23L_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 23-like
    Protein Accession:
    Q6PF05
    Secondary Accessions:
    • G8IJH6
    • Q6RGS4
    • Q8N7R3
    • Q96LJ2

    Protein attributes for TTC23L Gene

    Size:
    361 amino acids
    Molecular mass:
    40837 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK097766; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for TTC23L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC23L Gene

Post-translational modifications for TTC23L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC23L Gene

Domains & Families for TTC23L Gene

Gene Families for TTC23L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTC23L Gene

Suggested Antigen Peptide Sequences for TTC23L Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 23-like (TT23L_HUMAN)
genes like me logo Genes that share domains with TTC23L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC23L Gene

Function for TTC23L Gene

Phenotypes From GWAS Catalog for TTC23L Gene

Gene Ontology (GO) - Molecular Function for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with TTC23L: view
genes like me logo Genes that share phenotypes with TTC23L: view

Animal Model Products

CRISPR Products

miRNA for TTC23L Gene

miRTarBase miRNAs that target TTC23L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC23L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC23L Gene

Localization for TTC23L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC23L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase. {ECO:0000269 PubMed:25751302}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC23L gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 1
endoplasmic reticulum 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with TTC23L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TTC23L Gene

Pathways & Interactions for TTC23L Gene

PathCards logo

SuperPathways for TTC23L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress NAS 25751302
genes like me logo Genes that share ontologies with TTC23L: view

No data available for Pathways by source and SIGNOR curated interactions for TTC23L Gene

Drugs & Compounds for TTC23L Gene

No Compound Related Data Available

Transcripts for TTC23L Gene

mRNA/cDNA for TTC23L Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC23L

Alternative Splicing Database (ASD) splice patterns (SP) for TTC23L Gene

No ASD Table

Relevant External Links for TTC23L Gene

GeneLoc Exon Structure for
TTC23L

Expression for TTC23L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC23L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TTC23L Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for TTC23L Gene

This gene is overexpressed in Fetal Brain (49.2) and Platelet (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC23L Gene



Protein tissue co-expression partners for TTC23L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC23L

SOURCE GeneReport for Unigene cluster for TTC23L Gene:

Hs.435742
genes like me logo Genes that share expression patterns with TTC23L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC23L Gene

Orthologs for TTC23L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC23L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC23L 30 31
  • 97.96 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC23L 30 31
  • 86.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc23l 30
  • 80.66 (n)
Cow
(Bos Taurus)
Mammalia TTC23L 30 31
  • 79.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttc23l 30 17 31
  • 79.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TTC23L 31
  • 39 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC23L 31
  • 28 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc23l 30
  • 56.61 (n)
Species where no ortholog for TTC23L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TTC23L Gene

ENSEMBL:
Gene Tree for TTC23L (if available)
TreeFam:
Gene Tree for TTC23L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC23L: view image

Paralogs for TTC23L Gene

Paralogs for TTC23L Gene

genes like me logo Genes that share paralogs with TTC23L: view

Variants for TTC23L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC23L Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs34566695 - p.Thr150Met
rs34702907 - p.Lys247Asn
rs35665026 - p.Arg325Lys
rs35769440 - p.Asn153Asp
rs6451173 - p.His22Arg

Additional dbSNP identifiers (rs#s) for TTC23L Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC23L Gene

Variant ID Type Subtype PubMed ID
dgv1020e199 CNV deletion 23128226
dgv5629n100 CNV gain 25217958
esv1002836 CNV deletion 20482838
esv2235962 CNV deletion 18987734
esv2664297 CNV deletion 23128226
esv2730057 CNV deletion 23290073
esv2730058 CNV deletion 23290073
esv3565797 CNV deletion 23714750
esv3604679 CNV gain 21293372
esv3604684 CNV gain 21293372
esv3604689 CNV loss 21293372
esv3604690 CNV gain 21293372
esv4902 CNV loss 18987735
nsv1112419 CNV deletion 24896259
nsv327644 CNV deletion 16902084
nsv522144 CNV loss 19592680
nsv597809 CNV gain 21841781

Variation tolerance for TTC23L Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC23L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC23L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC23L Gene

Disorders for TTC23L Gene

Additional Disease Information for TTC23L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for TTC23L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC23L Gene

Publications for TTC23L Gene

  1. FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones. (PMID: 25751302) Pan TL … Ouyang P (Cell cycle (Georgetown, Tex.) 2015) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. (PMID: 29426014) Martínez-Noël G … Howley PM (Journal of molecular biology 2018) 3

Products for TTC23L Gene

Sources for TTC23L Gene