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Aliases for TTC23 Gene

Aliases for TTC23 Gene

  • Tetratricopeptide Repeat Domain 23 2 3 5
  • Cervical Cancer Proto-Oncogene 8 Protein 3 4
  • TPR Repeat Protein 23 3 4
  • HCC-8 3 4
  • Tetratricopeptide Repeat Protein 23 3

External Ids for TTC23 Gene

Previous GeneCards Identifiers for TTC23 Gene

  • GC15M097496
  • GC15M099676
  • GC15M075806

Summaries for TTC23 Gene

GeneCards Summary for TTC23 Gene

TTC23 (Tetratricopeptide Repeat Domain 23) is a Protein Coding gene. An important paralog of this gene is TTC23L.

Additional gene information for TTC23 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC23 Gene

Genomics for TTC23 Gene

GeneHancer (GH) Regulatory Elements for TTC23 Gene

Promoters and enhancers for TTC23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I099248 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 574.2 +0.9 850 4.5 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TTC23 LRRC28 PIR36219 SYNM GC15M099193
GH15I099563 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 -315.2 -315231 5.5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2A ENSG00000259921 HSP90B2P CERS3-AS1 TTC23 LYSMD4 ENSG00000201724 GC15M099683
GH15I099320 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.8 -71.8 -71782 5.4 FOXA2 SIN3A FOS RUNX3 RXRA SP5 REST PPARG MEF2D NFIL3 TTC23 SYNM ENSG00000259257 GC15P099286 LRRC28
GH15I099104 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +144.9 144907 3.8 HDGF ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF143 RUNX3 SP3 NFYC SYNM LOC105371016 PIR44206 ENSG00000261616 TTC23 LRRC28
GH15I099276 Enhancer 0.7 dbSUPER 29.6 -25.9 -25944 2.3 PKNOX1 L3MBTL2 OSR2 ZFP69B ZNF335 PRDM6 ZNF610 ZNF692 ZBTB48 GLIS1 TTC23 LRRC28 MEF2A SYNM HNRNPA1P62 HSP90B2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC23 gene promoter:

Genomic Locations for TTC23 Gene

Genomic Locations for TTC23 Gene
chr15:99,136,323-99,251,226
(GRCh38/hg38)
Size:
114,904 bases
Orientation:
Minus strand
chr15:99,676,528-99,791,428
(GRCh37/hg19)

Genomic View for TTC23 Gene

Genes around TTC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC23 Gene

Proteins for TTC23 Gene

  • Protein details for TTC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W5X9-TTC23_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 23
    Protein Accession:
    Q5W5X9
    Secondary Accessions:
    • A8K6M5
    • Q53HK0
    • Q96BC9
    • Q9H8W9
    • Q9H9S7

    Protein attributes for TTC23 Gene

    Size:
    447 amino acids
    Molecular mass:
    50009 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14144.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC23 Gene

Post-translational modifications for TTC23 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TTC23 Gene

Domains & Families for TTC23 Gene

Gene Families for TTC23 Gene

Protein Domains for TTC23 Gene

Suggested Antigen Peptide Sequences for TTC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC23: view

No data available for UniProtKB/Swiss-Prot for TTC23 Gene

Function for TTC23 Gene

Gene Ontology (GO) - Molecular Function for TTC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC23: view
genes like me logo Genes that share phenotypes with TTC23: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC23 Gene

Localization for TTC23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC23 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC23 Gene

Pathways & Interactions for TTC23 Gene

SuperPathways for TTC23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC23 Gene

Drugs & Compounds for TTC23 Gene

No Compound Related Data Available

Transcripts for TTC23 Gene

mRNA/cDNA for TTC23 Gene

Unigene Clusters for TTC23 Gene

Tetratricopeptide repeat domain 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7: - -
SP8:
SP9: - - - - -

Relevant External Links for TTC23 Gene

GeneLoc Exon Structure for
TTC23
ECgene alternative splicing isoforms for
TTC23

Expression for TTC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC23 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC23 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC23 Gene:

TTC23

SOURCE GeneReport for Unigene cluster for TTC23 Gene:

Hs.513195
genes like me logo Genes that share expression patterns with TTC23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC23 Gene

Orthologs for TTC23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC23 33 34
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia TTC23 33 34
  • 86.05 (n)
cow
(Bos Taurus)
Mammalia TTC23 33 34
  • 82.96 (n)
mouse
(Mus musculus)
Mammalia Ttc23 33 16 34
  • 79.67 (n)
rat
(Rattus norvegicus)
Mammalia Ttc23 33
  • 78.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC23 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC23 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ttc23 33 34
  • 51.95 (n)
Species where no ortholog for TTC23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC23 Gene

ENSEMBL:
Gene Tree for TTC23 (if available)
TreeFam:
Gene Tree for TTC23 (if available)

Paralogs for TTC23 Gene

Paralogs for TTC23 Gene

genes like me logo Genes that share paralogs with TTC23: view

Variants for TTC23 Gene

Sequence variations from dbSNP and Humsavar for TTC23 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000007585 -- 99,178,743(-) C/T intron_variant
rs1000021121 -- 99,250,649(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000038590 -- 99,231,469(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000042908 -- 99,147,655(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000105733 -- 99,225,556(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC23 Gene

Variant ID Type Subtype PubMed ID
nsv570716 CNV gain 21841781
nsv478852 CNV novel sequence insertion 20440878
nsv1055008 CNV gain 25217958
nsv1045124 CNV gain 25217958
esv3892741 CNV gain 25118596
esv3637425 CNV loss 21293372
esv3637424 CNV gain 21293372
esv3637423 CNV loss 21293372
esv3637422 CNV loss 21293372
esv3637421 CNV loss 21293372
esv2760374 CNV loss 21179565
esv2664025 CNV deletion 23128226
esv2661935 CNV deletion 23128226
esv2656470 CNV deletion 23128226

Variation tolerance for TTC23 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC23 Gene

Disorders for TTC23 Gene

Additional Disease Information for TTC23

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TTC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC23 Gene

Publications for TTC23 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B … Wanker EE (Nucleic acids research 2013) 3 58

Products for TTC23 Gene

Sources for TTC23 Gene

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