Aliases for TTC17 Gene

Aliases for TTC17 Gene

  • Tetratricopeptide Repeat Domain 17 2 3 5
  • Tetratricopeptide Repeat Protein 17 3 4
  • TPR Repeat Protein 17 3 4

External Ids for TTC17 Gene

Previous GeneCards Identifiers for TTC17 Gene

  • GC11P043344
  • GC11P043337
  • GC11P043090

Summaries for TTC17 Gene

GeneCards Summary for TTC17 Gene

TTC17 (Tetratricopeptide Repeat Domain 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TTC17 Gene

  • Plays a role in primary ciliogenesis by modulating actin polymerization.

Additional gene information for TTC17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC17 Gene

Genomics for TTC17 Gene

GeneHancer (GH) Regulatory Elements for TTC17 Gene

Promoters and enhancers for TTC17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC17 gene promoter:
  • aMEF-2
  • AML1a
  • CUTL1
  • E47
  • IRF-7A
  • ITF-2
  • MEF-2
  • MEF-2A
  • Tal-1beta
  • Zic3

Genomic Locations for TTC17 Gene

Genomic Locations for TTC17 Gene
chr11:43,358,885-43,494,933
(GRCh38/hg38)
Size:
136,049 bases
Orientation:
Plus strand
chr11:43,380,435-43,516,483
(GRCh37/hg19)
Size:
136,049 bases
Orientation:
Plus strand

Genomic View for TTC17 Gene

Genes around TTC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC17 Gene

Proteins for TTC17 Gene

  • Protein details for TTC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AE7-TTC17_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 17
    Protein Accession:
    Q96AE7
    Secondary Accessions:
    • G3XAB3
    • Q8NEC0

    Protein attributes for TTC17 Gene

    Size:
    1141 amino acids
    Molecular mass:
    129558 Da
    Quaternary structure:
    • Interacts with CATIP.

    Alternative splice isoforms for TTC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC17 Gene

Post-translational modifications for TTC17 Gene

  • Glycosylation at Asn634
  • Ubiquitination at Lys261
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TTC17_HUMAN (1799)

No data available for DME Specific Peptides for TTC17 Gene

Domains & Families for TTC17 Gene

Gene Families for TTC17 Gene

Protein Domains for TTC17 Gene

Suggested Antigen Peptide Sequences for TTC17 Gene

GenScript: Design optimal peptide antigens:
  • TTC17 protein (Q49A97_HUMAN)
  • TTC17 protein (Q8NEC0_HUMAN)
  • Tetratricopeptide repeat protein 17 (TTC17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96AE7

UniProtKB/Swiss-Prot:

TTC17_HUMAN :
  • Belongs to the TTC17 family.
Family:
  • Belongs to the TTC17 family.
genes like me logo Genes that share domains with TTC17: view

Function for TTC17 Gene

Molecular function for TTC17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.

Phenotypes From GWAS Catalog for TTC17 Gene

Gene Ontology (GO) - Molecular Function for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24475127
genes like me logo Genes that share ontologies with TTC17: view
genes like me logo Genes that share phenotypes with TTC17: view

Animal Model Products

CRISPR Products

miRNA for TTC17 Gene

miRTarBase miRNAs that target TTC17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC17 Gene

Localization for TTC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC17 Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC17 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 4
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 24475127
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,IDA 24475127
GO:0015629 actin cytoskeleton IDA 24475127
genes like me logo Genes that share ontologies with TTC17: view

Pathways & Interactions for TTC17 Gene

PathCards logo

SuperPathways for TTC17 Gene

No Data Available

Interacting Proteins for TTC17 Gene

Gene Ontology (GO) - Biological Process for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030041 actin filament polymerization IBA,IMP 24475127
GO:0044782 cilium organization IMP 24475127
genes like me logo Genes that share ontologies with TTC17: view

No data available for Pathways by source and SIGNOR curated interactions for TTC17 Gene

Drugs & Compounds for TTC17 Gene

No Compound Related Data Available

Transcripts for TTC17 Gene

mRNA/cDNA for TTC17 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 18c ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: - - - - - - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for TTC17 Gene

GeneLoc Exon Structure for
TTC17
ECgene alternative splicing isoforms for
TTC17

Expression for TTC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC17 Gene

Protein differential expression in normal tissues from HIPED for TTC17 Gene

This gene is overexpressed in Placenta (25.9), Testis (17.0), Peripheral blood mononuclear cells (12.9), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC17 Gene



Protein tissue co-expression partners for TTC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC17 Gene:

TTC17

SOURCE GeneReport for Unigene cluster for TTC17 Gene:

Hs.191186

mRNA Expression by UniProt/SwissProt for TTC17 Gene:

Q96AE7-TTC17_HUMAN
Tissue specificity: Expressed in germ cells as well as in somatic cells of the testis (at protein level).

Evidence on tissue expression from TISSUES for TTC17 Gene

  • Lung(4.5)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with TTC17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC17 Gene

Orthologs for TTC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC17 33 32
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TTC17 33 32
  • 92.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TTC17 33 32
  • 92.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc17 17 33 32
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia Ttc17 32
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC17 33
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC17 33
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC17 33 32
  • 77.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC17 33
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc17 32
  • 67.46 (n)
Str.17174 32
zebrafish
(Danio rerio)
Actinopterygii ttc17 32
  • 65.16 (n)
TTC17 33
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11436 33
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T19A5.1 33
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1286 33
  • 30 (a)
OneToOne
Species where no ortholog for TTC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC17 Gene

ENSEMBL:
Gene Tree for TTC17 (if available)
TreeFam:
Gene Tree for TTC17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC17: view image

Paralogs for TTC17 Gene

(1) SIMAP similar genes for TTC17 Gene using alignment to 6 proteins:

  • TTC17_HUMAN
  • E9PN79_HUMAN
  • G3XAB3_HUMAN
  • H0Y6S0_HUMAN
  • Q49A97_HUMAN
  • Q8NEC0_HUMAN
genes like me logo Genes that share paralogs with TTC17: view

No data available for Paralogs for TTC17 Gene

Variants for TTC17 Gene

Sequence variations from dbSNP and Humsavar for TTC17 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000012796 -- 43,387,004(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000050524 -- 43,474,047(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000059042 -- 43,473,557(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000098104 -- 43,378,383(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000146357 -- 43,464,665(+) A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC17 Gene

Variant ID Type Subtype PubMed ID
esv2678898 CNV deletion 23128226
esv3578660 CNV gain 25503493
esv3626145 CNV loss 21293372
esv3626146 CNV gain 21293372
nsv519819 CNV gain 19592680
nsv554119 CNV gain 21841781
nsv7753 CNV insertion 18451855
nsv975169 CNV duplication 23825009

Variation tolerance for TTC17 Gene

Residual Variation Intolerance Score: 4.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC17 Gene

Disorders for TTC17 Gene

Additional Disease Information for TTC17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TTC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC17 Gene

Publications for TTC17 Gene

  1. C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. (PMID: 24475127) Bontems F … Lane L (PloS one 2014) 2 3 4 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for TTC17 Gene

Sources for TTC17 Gene