Aliases for TTC17 Gene
External Ids for TTC17 Gene
- HGNC: 25596
- Entrez Gene: 55761
- Ensembl: ENSG00000052841
- UniProtKB: Q96AE7
Previous GeneCards Identifiers for TTC17 Gene
- GC11P043344
- GC11P043337
- GC11P043090
Summaries for TTC17 Gene
GeneCards Summary for TTC17 Gene
TTC17 (Tetratricopeptide Repeat Domain 17) is a Protein Coding gene.
UniProtKB/Swiss-Prot for TTC17 Gene
-
Plays a role in primary ciliogenesis by modulating actin polymerization.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC17 Gene
Genomics for TTC17 Gene
GeneHancer (GH) Regulatory Elements for TTC17 Gene
Promoters and enhancers for TTC17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TTC17 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TTC17 Gene
Genomic Locations for TTC17 Gene
- chr11:43,358,885-43,494,933
- (GRCh38/hg38)
- Size:
- 136,049 bases
- Orientation:
- Plus strand
- chr11:43,380,435-43,516,483
- (GRCh37/hg19)
Genomic View for TTC17 Gene
Genes around TTC17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p12 by Ensembl
- 11p12-p11.2 by Entrez Gene
- 11p12-p11.2 by HGNC
TTC17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TTC17 Gene
Proteins for TTC17 Gene
-
Protein details for TTC17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96AE7-TTC17_HUMAN
- Recommended name:
- Tetratricopeptide repeat protein 17
- Protein Accession:
- Q96AE7
- G3XAB3
- Q8NEC0
Protein attributes for TTC17 Gene
- Size:
- 1141 amino acids
- Molecular mass:
- 129558 Da
- Quaternary structure:
-
- Interacts with CATIP.
Protein Expression for TTC17 Gene
Post-translational modifications for TTC17 Gene
- Ubiquitination at isoforms=2261
Other Protein References for TTC17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TTC17
- Novus Biologicals Antibodies for TTC17
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Protein Products
-
OriGene Purified Proteins for TTC17
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- Search GeneTex for Proteins for TTC17
Assay Products
No data available for DME Specific Peptides for TTC17 Gene
Domains & Families for TTC17 Gene
Gene Families for TTC17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TTC17 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TTC17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96AE7- Family:
-
- Belongs to the TTC17 family.
Function for TTC17 Gene
Molecular function for TTC17 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in primary ciliogenesis by modulating actin polymerization.
Phenotypes From GWAS Catalog for TTC17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 24475127 |
Phenotypes for TTC17 Gene
- GenomeRNAi human phenotypes for TTC17:
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for TTC17
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- Overview of 96 available TTC17 gene related products
- Applied Biological Materials CRISPR for TTC17
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TTC17
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miRNA for TTC17 Gene
- miRTarBase miRNAs that target TTC17
miRNA Products
- Search ViGene Biosciences for TTC17
Inhibitory RNA Products
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- Overview of 96 available TTC17 gene related products
-
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Clone Products
- Sino Biological Human cDNA Clone for TTC17
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TTC17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TTC17
-
ViGene Biosciences adenoviral particle packaged cDNA for TTC17 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC17 Gene
Localization for TTC17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TTC17 Gene
- Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 24475127 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IDA,IEA | 24475127 |
| GO:0015629 | actin cytoskeleton | IDA | 24475127 |
Pathways & Interactions for TTC17 Gene
No Data Available
Interacting Proteins for TTC17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030030 | cell projection organization | IEA | -- |
| GO:0030041 | actin filament polymerization | IMP | 24475127 |
| GO:0044782 | cilium organization | IMP | 24475127 |
No data available for Pathways by source and SIGNOR curated interactions for TTC17 Gene
Transcripts for TTC17 Gene
mRNA/cDNA for TTC17 Gene
- (6) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (419) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TTC17 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TTC17
- genomics-online: gRNA clones - Search results for 96 available TTC17 gene related products
- Overview of 96 available TTC17 gene related products
- Applied Biological Materials CRISPR for TTC17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TTC17
- GenScript: Design CRISPR guide RNA sequences for TTC17
miRNA Products
- Search ViGene Biosciences for TTC17
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TTC17
- Browse OriGene Inhibitory RNA Products For TTC17
- genomics-online: shRNA clones - Search results for 96 available TTC17 gene related products
- Overview of 96 available TTC17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TTC17 gene
Clone Products
- Sino Biological Human cDNA Clone for TTC17
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TTC17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TTC17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TTC17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 18c | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||
| SP11: |
Expression for TTC17 Gene
This gene is overexpressed in Placenta (25.9), Testis (17.0), Peripheral blood mononuclear cells (12.9), and Retina (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC17 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TTC17 Gene:
TTC17SOURCE GeneReport for Unigene cluster for TTC17 Gene:
Hs.191186mRNA Expression by UniProt/SwissProt for TTC17 Gene:
Q96AE7-TTC17_HUMAN
Tissue specificity:
Expressed in germ cells as well as in somatic cells of the testis (at protein level).
Evidence on tissue expression from TISSUES for TTC17 Gene
- Lung(4.5)
- Nervous system(3.3)
Primer Products
-
OriGene qPCR primer pairs for TTC17
-
OriGene qPCR primer pairs and template standards for TTC17
- genomics-online: primer clones - Search results for 96 available TTC17 gene related products
- Overview of 96 available TTC17 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC17 Gene
Orthologs for TTC17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TTC17 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TTC17 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TTC17 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ttc17 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ttc17 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TTC17 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TTC17 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TTC17 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TTC17 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ttc17 33 |
|
||
| Str.17174 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ttc17 33 |
|
||
| TTC17 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11436 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | T19A5.1 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1286 34 |
|
OneToOne |
- Species where no ortholog for TTC17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TTC17 Gene
(1) SIMAP similar genes for TTC17 Gene using alignment to 6 proteins:
No data available for Paralogs for TTC17 Gene
Variants for TTC17 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012796 | -- | 43,387,004(+) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000050524 | -- | 43,474,047(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000059042 | -- | 43,473,557(+) | C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000098104 | -- | 43,378,383(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000146357 | -- | 43,464,665(+) | A/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv975169 | CNV | duplication | 23825009 |
| nsv7753 | CNV | insertion | 18451855 |
| nsv554119 | CNV | gain | 21841781 |
| nsv519819 | CNV | gain | 19592680 |
| esv3626146 | CNV | gain | 21293372 |
| esv3626145 | CNV | loss | 21293372 |
| esv3578660 | CNV | gain | 25503493 |
| esv2678898 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
4.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.12;
75.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TTC17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TTC17
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC17 Gene
Disorders for TTC17 Gene
Additional Disease Information for TTC17
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TTC17 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC17 Gene
Publications for TTC17 Gene
- C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. (PMID: 24475127) Bontems F … Lane L (PloS one 2014) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for TTC17 Gene
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- Invitrogen Antibodies for TTC17
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TTC17
- VectorBuilder custom plasmid, inducible vectors for TTC17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TTC17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available TTC17 related products ranked by validation data
- antibodies-online: Search results for available TTC17 related products ranked by validation data
- antibodies-online: Search results for available TTC17 related products ranked by validation data
- GeneTex TTC17 antibody for TTC17
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- ViGene Biosciences adenoviral particle packaged cDNA for TTC17 gene
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- genomics-online: gRNA clones - Search results for 96 available TTC17 gene related products
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- Overview of 96 available TTC17 gene related products
- genomics-online: shRNA clones - Search results for 96 available TTC17 gene related products
- Overview of 96 available TTC17 gene related products
Sources for TTC17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
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