Aliases for TTC16 Gene

Aliases for TTC16 Gene

  • Tetratricopeptide Repeat Domain 16 2 3 5
  • Tetratricopeptide Repeat Protein 16 3 4
  • TPR Repeat Protein 16 3 4
  • FLJ32780 2
  • TTC16 5

External Ids for TTC16 Gene

Previous GeneCards Identifiers for TTC16 Gene

  • GC09P125854
  • GC09P127557
  • GC09P129518
  • GC09P130466
  • GC09P100094
  • GC09P130478

Summaries for TTC16 Gene

GeneCards Summary for TTC16 Gene

TTC16 (Tetratricopeptide Repeat Domain 16) is a Protein Coding gene. An important paralog of this gene is TMTC2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC16 Gene

Genomics for TTC16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC16

Top Transcription factor binding sites by QIAGEN in the TTC16 gene promoter:
  • AML1a
  • Bach1
  • E47
  • En-1
  • FOXO4
  • Max1
  • Spz1
  • Tal-1
  • YY1

Genomic Locations for TTC16 Gene

Latest Assembly
chr9:127,716,064-127,731,590
(GRCh38/hg38)
Size:
15,527 bases
Orientation:
Plus strand

Previous Assembly
chr9:130,478,358-130,493,869
(GRCh37/hg19 by Entrez Gene)
Size:
15,512 bases
Orientation:
Plus strand

chr9:130,478,345-130,493,879
(GRCh37/hg19 by Ensembl)
Size:
15,535 bases
Orientation:
Plus strand

Genomic View for TTC16 Gene

Genes around TTC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC16 Gene

Proteins for TTC16 Gene

  • Protein details for TTC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEE8-TTC16_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 16
    Protein Accession:
    Q8NEE8
    Secondary Accessions:
    • B4DYG4
    • B5ME24
    • Q5JU66
    • Q96M72

    Protein attributes for TTC16 Gene

    Size:
    873 amino acids
    Molecular mass:
    98309 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC16 Gene

Post-translational modifications for TTC16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC16 Gene

Domains & Families for TTC16 Gene

Gene Families for TTC16 Gene

Protein Domains for TTC16 Gene

Suggested Antigen Peptide Sequences for TTC16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61473, highly similar to Tetratricopeptide repeat protein 16 (B4DYG4_HUMAN)
  • Tetratricopeptide repeat protein 16 (TTC16_HUMAN)
genes like me logo Genes that share domains with TTC16: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC16 Gene

Function for TTC16 Gene

Phenotypes From GWAS Catalog for TTC16 Gene

Gene Ontology (GO) - Molecular Function for TTC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC16: view
genes like me logo Genes that share phenotypes with TTC16: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC16 Gene

Localization for TTC16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC16 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TTC16 Gene

Pathways & Interactions for TTC16 Gene

PathCards logo

SuperPathways for TTC16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC16 Gene

Drugs & Compounds for TTC16 Gene

No Compound Related Data Available

Transcripts for TTC16 Gene

mRNA/cDNA for TTC16 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC16

Alternative Splicing Database (ASD) splice patterns (SP) for TTC16 Gene

No ASD Table

Relevant External Links for TTC16 Gene

GeneLoc Exon Structure for
TTC16

Expression for TTC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TTC16 Gene

This gene is overexpressed in Testis (x31.1) and Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for TTC16 Gene

This gene is overexpressed in Adipocyte (51.2) and Synovial fluid (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC16 Gene



Protein tissue co-expression partners for TTC16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC16

SOURCE GeneReport for Unigene cluster for TTC16 Gene:

Hs.642748
genes like me logo Genes that share expression patterns with TTC16: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC16 Gene

Orthologs for TTC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC16 30 31
  • 99.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC16 30 31
  • 79.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TTC16 30 31
  • 76.97 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ttc16 30 17 31
  • 72.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100362059 30
  • 69.21 (n)
Oppossum
(Monodelphis domestica)
Mammalia TTC16 31
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTC16 31
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TTC16 30 31
  • 55.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC16 31
  • 45 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToOne
Species where no ortholog for TTC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TTC16 Gene

ENSEMBL:
Gene Tree for TTC16 (if available)
TreeFam:
Gene Tree for TTC16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC16: view image

Paralogs for TTC16 Gene

genes like me logo Genes that share paralogs with TTC16: view

Variants for TTC16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC16 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs78007177 Uncertain Significance: Premature ovarian insufficiency 127,717,702(+) G/A
NM_144965.3(TTC16):c.356G>A (p.Arg119Gln)
MISSENSE
rs13298768 - p.Glu588Gly
rs17852941 - p.Met405Thr
rs17852943 - p.Ala872Ser
rs4837178 - p.Tyr809Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TTC16 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TTC16 Gene

Variant ID Type Subtype PubMed ID
dgv12879n54 CNV loss 21841781
nsv1137506 CNV deletion 24896259
nsv466571 CNV loss 19166990
nsv471323 CNV loss 18288195
nsv615369 CNV loss 21841781

Variation tolerance for TTC16 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC16

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC16 Gene

Disorders for TTC16 Gene

Additional Disease Information for TTC16

No disorders were found for TTC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC16 Gene

Publications for TTC16 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for TTC16 Gene

Sources for TTC16 Gene