Aliases for TTC13 Gene

Aliases for TTC13 Gene

  • Tetratricopeptide Repeat Domain 13 2 3 5
  • Tetratricopeptide Repeat Protein 13 3 4
  • TPR Repeat Protein 13 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • FLJ22584 2
  • TTC13 5

External Ids for TTC13 Gene

Previous GeneCards Identifiers for TTC13 Gene

  • GC01M228076
  • GC01M227348
  • GC01M229108
  • GC01M231041
  • GC01M201526

Summaries for TTC13 Gene

GeneCards Summary for TTC13 Gene

TTC13 (Tetratricopeptide Repeat Domain 13) is a Protein Coding gene. An important paralog of this gene is TMTC2.

Additional gene information for TTC13 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TTC13 Gene

Genomics for TTC13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TTC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J230976 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 614.6 +0.1 74 4 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST SIX5 IKZF1 TTC13 ARV1 C1orf131 EXOC8 FAM89A ENSG00000223393 SPRTN HSALNG0011415 C1orf198
GH01J230985 Enhancer 1 Ensembl ENCODE 11.4 -6.3 -6287 0.8 LEF1 IKZF1 MTA2 ZNF24 ZNF740 DPF2 HDAC1 SOX6 FOXJ2 GATAD2B TTC13 RF00951-011 ARV1 FAM89A
GH01J230987 Enhancer 0.6 Ensembl 13.5 -7.2 -7226 0.2 RFX1 OSR2 BCOR ZNF384 NUFIP1 ZBTB33 ZMYM3 ZNF362 DACH1 KLF14 TTC13 RF00951-011 ARV1 FAM89A
GH01J230971 Enhancer 0.7 ENCODE 9.1 +6.0 6001 2.2 POLR2A HDAC1 ETV6 SOX6 ARID3A RUNX3 NFE2 TCF7 HDAC2 LEF1 C1orf131 FAM89A ARV1 COG2 TTC13 C1orf198 HSALNG0011415
GH01J230986 Enhancer 0.5 Ensembl 11.9 -8.2 -8226 1 REST HMBOX1 JUND FOS FOSL1 FOSL2 ZNF384 POLR2A RF00951-011 TTC13 ARV1 FAM89A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTC13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TTC13

Top Transcription factor binding sites by QIAGEN in the TTC13 gene promoter:
  • aMEF-2
  • E47
  • Evi-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Hand1
  • Lmo2
  • MEF-2
  • MEF-2A

Genomic Locations for TTC13 Gene

Genomic Locations for TTC13 Gene
chr1:230,906,243-230,978,875
(GRCh38/hg38)
Size:
72,633 bases
Orientation:
Minus strand
chr1:231,041,987-231,114,621
(GRCh37/hg19)
Size:
72,635 bases
Orientation:
Minus strand

Genomic View for TTC13 Gene

Genes around TTC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC13 Gene

Proteins for TTC13 Gene

  • Protein details for TTC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBP0-TTC13_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 13
    Protein Accession:
    Q8NBP0
    Secondary Accessions:
    • B1AQI1
    • B1AQI2
    • Q8IVP8
    • Q8NBI0
    • Q8ND20

    Protein attributes for TTC13 Gene

    Size:
    860 amino acids
    Molecular mass:
    96813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC13 Gene

Post-translational modifications for TTC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC13 Gene

Domains & Families for TTC13 Gene

Gene Families for TTC13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TTC13 Gene

Suggested Antigen Peptide Sequences for TTC13 Gene

GenScript: Design optimal peptide antigens:
  • Tetratricopeptide repeat protein 13 (TTC13_HUMAN)
genes like me logo Genes that share domains with TTC13: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TTC13 Gene

Function for TTC13 Gene

Phenotypes From GWAS Catalog for TTC13 Gene

Gene Ontology (GO) - Molecular Function for TTC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC13: view
genes like me logo Genes that share phenotypes with TTC13: view

Animal Model Products

CRISPR Products

miRNA for TTC13 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC13

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC13 Gene

Localization for TTC13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC13 gene
Compartment Confidence
nucleus 2
endoplasmic reticulum 2
extracellular 1
plasma membrane 0
mitochondrion 0
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC13 Gene

Pathways & Interactions for TTC13 Gene

PathCards logo

SuperPathways for TTC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC13 Gene

Drugs & Compounds for TTC13 Gene

No Compound Related Data Available

Transcripts for TTC13 Gene

mRNA/cDNA for TTC13 Gene

10 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TTC13

Alternative Splicing Database (ASD) splice patterns (SP) for TTC13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1: - -
SP2: - - - -
SP3:
SP4:

ExUns: 24
SP1:
SP2:
SP3:
SP4:

Relevant External Links for TTC13 Gene

GeneLoc Exon Structure for
TTC13

Expression for TTC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC13 Gene

Protein differential expression in normal tissues from HIPED for TTC13 Gene

This gene is overexpressed in Placenta (50.6) and Adipocyte (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC13 Gene



Protein tissue co-expression partners for TTC13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TTC13

SOURCE GeneReport for Unigene cluster for TTC13 Gene:

Hs.424788

Evidence on tissue expression from TISSUES for TTC13 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TTC13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC13 Gene

Orthologs for TTC13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TTC13 30 31
  • 99.88 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TTC13 30 31
  • 93.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TTC13 30 31
  • 93.04 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TTC13 31
  • 91 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TTC13 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ttc13 30
  • 86.07 (n)
Mouse
(Mus musculus)
Mammalia Ttc13 30 17 31
  • 85.67 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TTC13 30 31
  • 81.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TTC13 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ttc13 30
  • 75.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15150 30
Zebrafish
(Danio rerio)
Actinopterygii ttc13 30 31
  • 72.4 (n)
OneToOne
Dr.17426 30
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SRFR1 30
  • 44.15 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0113700 30
  • 43.96 (n)
Species where no ortholog for TTC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TTC13 Gene

ENSEMBL:
Gene Tree for TTC13 (if available)
TreeFam:
Gene Tree for TTC13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTC13: view image

Paralogs for TTC13 Gene

(1) SIMAP similar genes for TTC13 Gene using alignment to 7 proteins:

  • TTC13_HUMAN
  • E5RG15_HUMAN
  • E5RHB3_HUMAN
  • E5RJP6_HUMAN
  • E9PGV4_HUMAN
  • H0YB10_HUMAN
  • H0YBV3_HUMAN
genes like me logo Genes that share paralogs with TTC13: view

Variants for TTC13 Gene

Additional dbSNP identifiers (rs#s) for TTC13 Gene

Structural Variations from Database of Genomic Variants (DGV) for TTC13 Gene

Variant ID Type Subtype PubMed ID
esv3589093 CNV gain 21293372
esv3589103 CNV loss 21293372
nsv1000488 CNV gain 25217958
nsv1011066 CNV gain 25217958

Variation tolerance for TTC13 Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TTC13 Gene

Disorders for TTC13 Gene

Additional Disease Information for TTC13

No disorders were found for TTC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC13 Gene

Publications for TTC13 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for TTC13 Gene

Sources for TTC13 Gene