Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSTD1 Gene

Aliases for TSTD1 Gene

  • Thiosulfate Sulfurtransferase Like Domain Containing 1 2 3 5
  • Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 1 2 3
  • KAT 3 4
  • TST 3 4
  • Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 1 3
  • Putative Thiosulfate Sulfurtransferase KAT 3
  • Thiosulfate:Glutathione Sulfurtransferase 3
  • EC 2.8.1.- 4

External Ids for TSTD1 Gene

Previous GeneCards Identifiers for TSTD1 Gene

  • GC01M159280
  • GC01M132365

Summaries for TSTD1 Gene

GeneCards Summary for TSTD1 Gene

TSTD1 (Thiosulfate Sulfurtransferase Like Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TSTD3.

UniProtKB/Swiss-Prot for TSTD1 Gene

  • Thiosulfate:glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).

Additional gene information for TSTD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTD1 Gene

Genomics for TSTD1 Gene

GeneHancer (GH) Regulatory Elements for TSTD1 Gene

Promoters and enhancers for TSTD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I161037 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 564.7 +0.2 237 2.2 HDGF PKNOX1 SIN3A ZNF2 YY1 GLIS2 ZNF143 RUNX3 SP3 GLIS1 TSTD1 ENSG00000270149 F11R LOC105371471 ARHGAP30 NECTIN4 ENSG00000232879 USF1
GH01I161066 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.5 -29.6 -29625 5.1 HDGF PKNOX1 BMI1 ZBTB40 KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 ARHGAP30 FCGR2A TSTD1 DUSP12 USP21 PPOX F11R DEDD NECTIN4 ENSG00000232879
GH01I161011 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 33.2 +21.8 21777 11.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 DUSP12 USP21 LOC100287049 DEDD PPOX TSTD1 LOC148430 B4GALT3 ARHGAP30 KLHDC9
GH01I161043 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.1 -7.9 -7899 5.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 GC01P161046 PIR33280 USF1 DEDD TSTD1 LOC100287049 ARHGAP30 LOC105371471 NECTIN4 KLHDC9
GH01I161073 Enhancer 1 Ensembl ENCODE 30.2 -35.5 -35504 2.2 ATF1 FOXA2 ARID4B KLF17 ZNF76 RAD21 ZEB1 GLIS2 SCRT2 ATF7 TSTD1 GC01P161070 LOC105371471 NECTIN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSTD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSTD1 Gene

Genomic Locations for TSTD1 Gene
chr1:161,037,631-161,038,990
(GRCh38/hg38)
Size:
1,360 bases
Orientation:
Minus strand
chr1:161,007,421-161,008,780
(GRCh37/hg19)

Genomic View for TSTD1 Gene

Genes around TSTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTD1 Gene

Proteins for TSTD1 Gene

  • Protein details for TSTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU3-TSTD1_HUMAN
    Recommended name:
    Thiosulfate:glutathione sulfurtransferase
    Protein Accession:
    Q8NFU3
    Secondary Accessions:
    • Q5SY48
    • Q5SY49
    • Q5SY50
    • Q5SY51
    • Q8NFU2
    • Q9BV22

    Protein attributes for TSTD1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12530 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15368.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSTD1 Gene

Post-translational modifications for TSTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSTD1 Gene

No data available for DME Specific Peptides for TSTD1 Gene

Domains & Families for TSTD1 Gene

Gene Families for TSTD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSTD1 Gene

Suggested Antigen Peptide Sequences for TSTD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSTD1: view

No data available for UniProtKB/Swiss-Prot for TSTD1 Gene

Function for TSTD1 Gene

Molecular function for TSTD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.0 mM for glutathione {ECO:0000269 PubMed:24981631}; KM=14.0 mM for thiosulfate {ECO:0000269 PubMed:24981631}; KM=0.04 mM for glutathione (in the presence of sulfur dioxygenase) {ECO:0000269 PubMed:24981631}; KM=10.7 mM for thiosulfate (in the presence of sulfur dioxygenase) {ECO:0000269 PubMed:24981631}; KM=11.0 mM for thiosulfate (when glutathione is the acceptor) {ECO:0000269 PubMed:24981631}; KM=10.4 mM for thiosulfate (when cystein is the acceptor) {ECO:0000269 PubMed:24981631}; KM=36.0 mM for thiosulfate (when coenzyme A is the acceptor) {ECO:0000269 PubMed:24981631}; KM=14.01 mM for thiosulfate (when DTT is the acceptor) {ECO:0000269 PubMed:24981631}; KM=12.0 mM for thiosulfate (when cyanide is the acceptor) {ECO:0000269 PubMed:24981631}; KM=1.7 mM for glutathione (when thiosulfate is the acceptor) {ECO:0000269 PubMed:24981631}; KM=2.5 mM for cystein (when thiosulfate is the acceptor) {ECO:0000269 PubMed:24981631}; KM=0.09 mM for coenzyme A (when thiosulfate is the acceptor) {ECO:0000269 PubMed:24981631}; KM=0.12 mM for DTT (when thiosulfate is the acceptor) {ECO:0000269 PubMed:24981631}; KM=0.22 mM for cyanide (when thiosulfate is the acceptor) {ECO:0000269 PubMed:24981631};
UniProtKB/Swiss-Prot EnzymeRegulation:
GSS(-) is a potent inhibitor of TSTD1, since the presence of the sulfur dioxygenase (SDO) strongly increases the TSTD1 catalytic activity (PubMed:24981631).
UniProtKB/Swiss-Prot Function:
Thiosulfate:glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).

Enzyme Numbers (IUBMB) for TSTD1 Gene

Phenotypes From GWAS Catalog for TSTD1 Gene

Gene Ontology (GO) - Molecular Function for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0050337 thiosulfate-thiol sulfurtransferase activity TAS --
genes like me logo Genes that share ontologies with TSTD1: view

Phenotypes for TSTD1 Gene

GenomeRNAi human phenotypes for TSTD1:
genes like me logo Genes that share phenotypes with TSTD1: view

miRNA for TSTD1 Gene

miRTarBase miRNAs that target TSTD1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSTD1 Gene

Localization for TSTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSTD1 Gene

Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSTD1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12817473
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSTD1: view

Pathways & Interactions for TSTD1 Gene

SuperPathways for TSTD1 Gene

No Data Available

Interacting Proteins for TSTD1 Gene

Gene Ontology (GO) - Biological Process for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS --
genes like me logo Genes that share ontologies with TSTD1: view

No data available for Pathways by source and SIGNOR curated interactions for TSTD1 Gene

Drugs & Compounds for TSTD1 Gene

(4) Additional Compounds for TSTD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cyanide
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
57-12-5
Sulfite
  • Bisulfite
  • Sulfite dianion
  • Sulfite ion
  • Sulfite ions
  • Sulfonate
14265-45-3
thiocyanate
  • Rhodanide
  • SCN
  • Ammonium sulfocyanate
  • HSCN
  • Hydrogen thiocyanate
302-04-5
thiosulfate
  • Hyposulfite
  • S-Hydril
  • Sodium hyposulfite
  • Sodium oxide sulfide (Na2S2O3)
  • Sodium thiosulfate
14383-50-7
genes like me logo Genes that share compounds with TSTD1: view

Transcripts for TSTD1 Gene

mRNA/cDNA for TSTD1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSTD1 Gene

Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSTD1 Gene

No ASD Table

Relevant External Links for TSTD1 Gene

GeneLoc Exon Structure for
TSTD1
ECgene alternative splicing isoforms for
TSTD1

Expression for TSTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTD1 Gene

This gene is overexpressed in Salivary gland (9.9), Skin (7.5), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSTD1 Gene



Protein tissue co-expression partners for TSTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSTD1 Gene:

TSTD1

SOURCE GeneReport for Unigene cluster for TSTD1 Gene:

Hs.720030

mRNA Expression by UniProt/SwissProt for TSTD1 Gene:

Q8NFU3-TSTD1_HUMAN
Tissue specificity: Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.
genes like me logo Genes that share expression patterns with TSTD1: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSTD1 Gene

Orthologs for TSTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSTD1 33 34
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia TSTD1 33 34
  • 86.43 (n)
dog
(Canis familiaris)
Mammalia TSTD1 33 34
  • 85.96 (n)
rat
(Rattus norvegicus)
Mammalia Tstd1 33
  • 82.46 (n)
mouse
(Mus musculus)
Mammalia Tstd1 33 16 34
  • 80.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TSTD1 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSTD1 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSTD1 34
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSTD1 34
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC563265 33
  • 56.79 (n)
TSTD1 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12279 34
  • 37 (a)
OneToMany
Hsp67Bb 34
  • 33 (a)
OneToMany
CG6000 34
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDL2 34 36
  • 23 (a)
OneToMany
RDL1 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for TSTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSTD1 Gene

ENSEMBL:
Gene Tree for TSTD1 (if available)
TreeFam:
Gene Tree for TSTD1 (if available)

Paralogs for TSTD1 Gene

Paralogs for TSTD1 Gene

Pseudogenes.org Pseudogenes for TSTD1 Gene

genes like me logo Genes that share paralogs with TSTD1: view

Variants for TSTD1 Gene

Sequence variations from dbSNP and Humsavar for TSTD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs2073658 risk-factor, Hyperlipidemia, familial combined, susceptibility to 161,040,972(-) C/T upstream_transcript_variant
rs3737787 risk-factor, Hyperlipidemia, familial combined, susceptibility to 161,039,733(-) G/A upstream_transcript_variant
rs1000010156 -- 161,040,145(-) A/G upstream_transcript_variant
rs1000080464 -- 161,038,710(-) G/A intron_variant
rs1000550967 -- 161,040,479(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSTD1 Gene

Variant ID Type Subtype PubMed ID
nsv3221 CNV deletion 18451855
nsv548059 CNV gain 21841781

Variation tolerance for TSTD1 Gene

Gene Damage Index Score: 1.06; 21.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSTD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTD1 Gene

Disorders for TSTD1 Gene

Additional Disease Information for TSTD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TSTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTD1 Gene

Publications for TSTD1 Gene

  1. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. (PMID: 12817473) Wenzel K … Hoehe MR (Biological chemistry 2003) 2 3 4 58
  2. Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog. (PMID: 24981631) Melideo SL … Jorns MS (Biochemistry 2014) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TSTD1 Gene

Sources for TSTD1 Gene

Content
Loading form....