This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in ... See more...

Aliases for TST Gene

Aliases for TST Gene

  • Thiosulfate Sulfurtransferase 2 3 4 5
  • Thiosulfate Sulfurtransferase (Rhodanese) 2 3
  • EC 2.8.1.1 4 52
  • Rhodanese 2 4
  • Epididymis Secretory Sperm Binding Protein 3
  • EC 2.8.1 52
  • RDS 3

External Ids for TST Gene

Previous GeneCards Identifiers for TST Gene

  • GC22M034021
  • GC22M035649
  • GC22M035731
  • GC22M037408
  • GC22M020372

Summaries for TST Gene

Entrez Gene Summary for TST Gene

  • This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for TST Gene

TST (Thiosulfate Sulfurtransferase) is a Protein Coding gene. Diseases associated with TST include Commensal Bacterial Infectious Disease and Salivary Gland Carcinoma. Among its related pathways are Metabolism and Sulfur amino acid metabolism. Gene Ontology (GO) annotations related to this gene include thiosulfate sulfurtransferase activity and 5S rRNA binding. An important paralog of this gene is MPST.

UniProtKB/Swiss-Prot Summary for TST Gene

  • Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Gene Wiki entry for TST Gene

Additional gene information for TST Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TST Gene

Genomics for TST Gene

GeneHancer (GH) Regulatory Elements for TST Gene

Promoters and enhancers for TST Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J037014 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.9 -0.5 -490 12.5 HNRNPK ZBTB40 EP300 CTCF POLR2G USF1 NCOR1 PHF8 JUND ZFX MPST TST EIF3D RBFOX2 RPS15AP38 KCTD17 ENSG00000231467 TMPRSS6 NCF4-AS1 NCF4
GH22J037030 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 5.4 -13.4 -13380 5.4 EP300 FOXK2 ZNF217 CTCF TCF12 POLR2G NCOR1 ZIC2 POLR2A KDM6A ENSG00000287236 TMPRSS6 MPST TEX33 ENSG00000231467 NCF4-AS1 NCF4 IL2RB GGA1 ENSG00000229971
GH22J037012 Enhancer 0.8 ENCODE dbSUPER 0.4 +7.7 7718 0 POLR2G NR2F2 RBM22 JUND RAD21 RXRA MAX POLR2A HNF4A REST ENSG00000252412 lnc-TEX33-1 TST
GH22J037010 Enhancer 0.7 Ensembl dbSUPER 0.4 +9.2 9182 0.8 HDAC2 POLR2A POLR2G TAF15 ADNP HNF4A PAF1 AGO2 MAX AGO1 lnc-TEX33-1 TEX33 TST
GH22J037027 Enhancer 0.4 dbSUPER 0.4 -7.5 -7538 1.1 POLR2G SCRT1 GLIS1 NR2F6 SCRT2 KCTD17 ENSG00000231467 TMPRSS6 NCF4-AS1 NCF4 IL2RB ENSG00000229971 TEX33 ENSG00000287236 MPST
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TST on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TST

Top Transcription factor binding sites by QIAGEN in the TST gene promoter:
  • AML1a
  • En-1
  • HNF-4alpha1
  • HNF-4alpha2
  • POU2F1
  • POU2F1a
  • RFX1
  • USF-1
  • USF1
  • ZID

Genomic Locations for TST Gene

Genomic Locations for TST Gene
chr22:37,010,859-37,020,183
(GRCh38/hg38)
Size:
9,325 bases
Orientation:
Minus strand
chr22:37,406,900-37,415,681
(GRCh37/hg19)
Size:
8,782 bases
Orientation:
Minus strand

Genomic View for TST Gene

Genes around TST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TST Gene

Proteins for TST Gene

  • Protein details for TST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16762-THTR_HUMAN
    Recommended name:
    Thiosulfate sulfurtransferase
    Protein Accession:
    Q16762
    Secondary Accessions:
    • B3KRM1
    • Q6IB06

    Protein attributes for TST Gene

    Size:
    297 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for TST Gene

Selected DME Specific Peptides for TST Gene

Q16762:
  • APRVWWMFR
  • ERHVPGASFFDIEECRD
  • SKRFQLVDSR
  • THVVVYDG
  • SPYEMMLPSEA

Post-translational modifications for TST Gene

  • Glycosylation at Ser35
  • Ubiquitination at Lys14
  • Modification sites at PhosphoSitePlus

Other Protein References for TST Gene

Domains & Families for TST Gene

Gene Families for TST Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TST Gene

Blocks:
  • Rhodanese-like
  • Thiosulfate sulfurtransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TST Gene

GenScript: Design optimal peptide antigens:
  • Rhodanese (THTR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16762

UniProtKB/Swiss-Prot:

THTR_HUMAN :
  • Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
Domain:
  • Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
genes like me logo Genes that share domains with TST: view

Function for TST Gene

Molecular function for TST Gene

UniProtKB/Swiss-Prot Function:
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate; Xref=Rhea:RHEA:16881, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:18022, ChEBI:CHEBI:18407, ChEBI:CHEBI:33542; EC=2.8.1.1;.
GENATLAS Biochemistry:
thiosulfate

Enzyme Numbers (IUBMB) for TST Gene

Phenotypes From GWAS Catalog for TST Gene

Gene Ontology (GO) - Molecular Function for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004792 thiosulfate sulfurtransferase activity TAS --
GO:0008097 5S rRNA binding IDA 20663881
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TST: view
genes like me logo Genes that share phenotypes with TST: view

Animal Models for TST Gene

MGI Knock Outs for TST:
  • Tst Tst<tm1.1(KOMP)Vlcg>
  • Tst Tst<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for TST Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TST

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TST Gene

Localization for TST Gene

Subcellular locations from UniProtKB/Swiss-Prot for TST Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TST gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005739 mitochondrion IBA,IDA --
GO:0005759 mitochondrial matrix NAS,TAS --
genes like me logo Genes that share ontologies with TST: view

Pathways & Interactions for TST Gene

genes like me logo Genes that share pathways with TST: view

Gene Ontology (GO) - Biological Process for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0009440 cyanate catabolic process TAS 9070219
GO:0019346 transsulfuration IBA 21873635
GO:0030855 epithelial cell differentiation IDA 21492153
GO:0035928 rRNA import into mitochondrion IMP 20663881
genes like me logo Genes that share ontologies with TST: view

No data available for SIGNOR curated interactions for TST Gene

Drugs & Compounds for TST Gene

(15) Drugs for TST Gene - From: DrugBank, ClinicalTrials, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiosulfuric acid Approved, Investigational Pharma Enzyme, substrate 0
Isoniazid Approved, Investigational Pharma 211
Zaleplon Approved, Illicit, Investigational Pharma Full agonist, Allosteric regulator 23
Iron Approved, Experimental Pharma 1496
Pyruvic acid Approved, Investigational Nutra 0

(8) Additional Compounds for TST Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cyanide
  • Carbon nitride ion
  • Chuck norrisium
  • Cyanide ion
  • Cyanide(1-) ion
  • Cyano
57-12-5
thiosulfate
  • [SO2(OH)(SH)]
  • H2S2O3
  • Thiosulfuric acid
  • Hydroxidodioxidosulfidosulfuric acid
  • Hydroxidodioxidosulphidosulphate
14383-50-7
3-Mercaptopyruvic acid
  • 3-mercapto-2-Oxopropanoic acid
  • 3-Mercaptopyruvate
  • Mercaptopyruvate
  • 3-mercapto-2-Oxopropanoate
  • Mercaptopyruvic acid
2464-23-5
Hydrogen cyanide
  • [CHN]
  • Blausaeure
  • Cyanwasserstoff
  • Formonitrile
  • HCN
Sulfite
  • [so(OH)2]
  • Acide sulfureux
  • acido Sulfuroso
  • H2SO3
  • S(O)(OH)2
14265-45-3, 15181-46-1
genes like me logo Genes that share compounds with TST: view

Transcripts for TST Gene

mRNA/cDNA for TST Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TST

Alternative Splicing Database (ASD) splice patterns (SP) for TST Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for TST Gene

GeneLoc Exon Structure for
TST

Expression for TST Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TST Gene

mRNA differential expression in normal tissues according to GTEx for TST Gene

This gene is overexpressed in Liver (x10.0) and Colon - Transverse (x5.9).

Protein differential expression in normal tissues from HIPED for TST Gene

This gene is overexpressed in Liver, secretome (12.3) and Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TST Gene



Protein tissue co-expression partners for TST Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TST

SOURCE GeneReport for Unigene cluster for TST Gene:

Hs.474783

Evidence on tissue expression from TISSUES for TST Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Blood(4.4)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with TST: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TST Gene

Orthologs for TST Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TST 31 30
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TST 31 30
  • 90.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TST 31 30
  • 88.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tst 30
  • 85.97 (n)
mouse
(Mus musculus)
Mammalia Tst 17 31 30
  • 85.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TST 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TST 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves TST 31 30
  • 72.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TST 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492858 30
  • 65.72 (n)
zebrafish
(Danio rerio)
Actinopterygii MPST 31
  • 55 (a)
OneToMany
wufa96h11 30
worm
(Caenorhabditis elegans)
Secernentea mpst-7 31 30
  • 45.53 (n)
ManyToMany
mpst-5 31
  • 27 (a)
ManyToMany
mpst-6 31
  • 27 (a)
ManyToMany
mpst-4 31
  • 26 (a)
ManyToMany
mpst-1 31
  • 23 (a)
ManyToMany
mpst-2 31
  • 22 (a)
ManyToMany
mpst-3 31
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUM1 31
  • 23 (a)
OneToMany
Species where no ortholog for TST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TST Gene

ENSEMBL:
Gene Tree for TST (if available)
TreeFam:
Gene Tree for TST (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TST: view image

Paralogs for TST Gene

Paralogs for TST Gene

(1) SIMAP similar genes for TST Gene using alignment to 2 proteins:

  • THTR_HUMAN
  • B1AH48_HUMAN
genes like me logo Genes that share paralogs with TST: view

Variants for TST Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TST Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
757701 Likely Benign: not provided 37,018,280(-) G/C SYNONYMOUS_VARIANT
766035 Likely Benign: not provided 37,018,129(-) G/A INTRON_VARIANT
rs1049270 - p.Glu228Gly
rs35156365 - p.Glu102Asp

Additional dbSNP identifiers (rs#s) for TST Gene

Structural Variations from Database of Genomic Variants (DGV) for TST Gene

Variant ID Type Subtype PubMed ID
esv2661268 CNV deletion 23128226
esv34015 CNV loss 18971310
esv3558139 CNV deletion 23714750
esv3647699 CNV loss 21293372
nsv1057409 CNV gain 25217958
nsv3622 CNV insertion 18451855
nsv459882 CNV gain 19166990
nsv588984 CNV gain 21841781
nsv829203 CNV loss 20364138
nsv834187 CNV loss 17160897

Variation tolerance for TST Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TST Gene

Human Gene Mutation Database (HGMD)
TST
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TST

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TST Gene

Disorders for TST Gene

MalaCards: The human disease database

(19) MalaCards diseases for TST Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TST in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TST

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TST Gene

Publications for TST Gene

  1. Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. (PMID: 21685364) Smirnov A … Tarassov I (Genes & development 2011) 3 4 54
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  3. Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients. (PMID: 19695240) Krueger K … Scholze A (Clinical biochemistry 2010) 3 23 54
  4. Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria. (PMID: 20663881) Smirnov A … Tarassov I (The Journal of biological chemistry 2010) 3 4 54
  5. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. (PMID: 16500920) Ramasamy S … Eggo MC (American journal of physiology. Gastrointestinal and liver physiology 2006) 3 23 54

Products for TST Gene

Sources for TST Gene