Aliases for TST Gene
External Ids for TST Gene
Previous GeneCards Identifiers for TST Gene
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for TST Gene
TST (Thiosulfate Sulfurtransferase) is a Protein Coding gene. Diseases associated with TST include Commensal Bacterial Infectious Disease and Salivary Gland Carcinoma. Among its related pathways are Sulfur amino acid metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include thiosulfate sulfurtransferase activity and 5S rRNA binding. An important paralog of this gene is MPST.
UniProtKB/Swiss-Prot Summary for TST Gene
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.