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This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
TST (Thiosulfate Sulfurtransferase) is a Protein Coding gene. Diseases associated with TST include Commensal Bacterial Infectious Disease and Salivary Gland Carcinoma. Among its related pathways are Sulfur amino acid metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include thiosulfate sulfurtransferase activity and 5S rRNA binding. An important paralog of this gene is MPST.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0004792 | thiosulfate sulfurtransferase activity | TAS | -- |
GO:0008097 | 5S rRNA binding | IDA | 20663881 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 23580065 |
GO:0005739 | mitochondrion | IBA,IDA | -- |
GO:0005759 | mitochondrial matrix | NAS,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sulfur amino acid metabolism | ||
2 | Metabolism |
.40
|
|
3 | Sulfur metabolism | ||
4 | Sulfur relay system | ||
5 | Viral mRNA Translation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000098 | sulfur amino acid catabolic process | TAS | -- |
GO:0009440 | cyanate catabolic process | TAS | 9070219 |
GO:0019346 | transsulfuration | IBA | 21873635 |
GO:0030855 | epithelial cell differentiation | IDA | 21492153 |
GO:0035928 | rRNA import into mitochondrion | IMP | 20663881 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Thiosulfuric acid | Approved, Investigational | Pharma | Enzyme, substrate | 0 | ||
Isoniazid | Approved, Investigational | Pharma | 215 | |||
Zaleplon | Approved, Illicit, Investigational | Pharma | Allosteric regulator, Full agonist | 24 | ||
Iron | Approved, Experimental | Pharma | 1560 | |||
Pyruvic acid | Approved, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
cyanide |
|
57-12-5 | ||||
thiosulfate |
|
14383-50-7 | ||||
3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
Hydrogen cyanide |
|
|
||||
Sulfite |
|
14265-45-3, 15181-46-1 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TST 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TST 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TST 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tst 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tst 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TST 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TST 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TST 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TST 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492858 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | MPST 31 |
|
OneToMany | |
wufa96h11 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | mpst-7 30 31 |
|
ManyToMany | |
mpst-5 31 |
|
ManyToMany | |||
mpst-6 31 |
|
ManyToMany | |||
mpst-4 31 |
|
ManyToMany | |||
mpst-1 31 |
|
ManyToMany | |||
mpst-2 31 |
|
ManyToMany | |||
mpst-3 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TUM1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
757701 | Likely Benign: not provided | 37,018,280(-) | G/C | SYNONYMOUS_VARIANT | |
766035 | Likely Benign: not provided | 37,018,129(-) | G/A | INTRON_VARIANT | |
rs1049270 | - | p.Glu228Gly | |||
rs35156365 | - | p.Glu102Asp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2661268 | CNV | deletion | 23128226 |
esv34015 | CNV | loss | 18971310 |
esv3558139 | CNV | deletion | 23714750 |
esv3647699 | CNV | loss | 21293372 |
nsv1057409 | CNV | gain | 25217958 |
nsv3622 | CNV | insertion | 18451855 |
nsv459882 | CNV | gain | 19166990 |
nsv588984 | CNV | gain | 21841781 |
nsv829203 | CNV | loss | 20364138 |
nsv834187 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
commensal bacterial infectious disease |
|
|
salivary gland carcinoma |
|
|
carbuncle |
|
|
encephalopathy, ethylmalonic |
|
|
myeloproliferative syndrome, transient |
|
|