Aliases for TSSK4 Gene
External Ids for TSSK4 Gene
Previous HGNC Symbols for TSSK4 Gene
Previous GeneCards Identifiers for TSSK4 Gene
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
GeneCards Summary for TSSK4 Gene
TSSK4 (Testis Specific Serine Kinase 4) is a Protein Coding gene. Diseases associated with TSSK4 include Oligospermia. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK2.
UniProtKB/Swiss-Prot Summary for TSSK4 Gene
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).