Aliases for TSSK4 Gene
External Ids for TSSK4 Gene
Previous HGNC Symbols for TSSK4 Gene
Previous GeneCards Identifiers for TSSK4 Gene
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
GeneCards Summary for TSSK4 Gene
TSSK4 (Testis Specific Serine Kinase 4) is a Protein Coding gene. Diseases associated with TSSK4 include Glanders and Oligospermia. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK1B.
UniProtKB/Swiss-Prot Summary for TSSK4 Gene
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).