This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008] See more...

Aliases for TSSK3 Gene

Aliases for TSSK3 Gene

  • Testis Specific Serine Kinase 3 2 3 5
  • Testis-Specific Serine/Threonine-Protein Kinase 3 3 4
  • Serine/Threonine-Protein Kinase 22C 3 4
  • Testis-Specific Kinase 3 3 4
  • STK22C 3 4
  • SPOGA3 3 4
  • TSSK-3 3 4
  • TSK-3 3 4
  • Serine/Threonine Kinase 22C (Spermiogenesis Associated) 2
  • Testis-Specific Serine/Threonine Kinase 22C 3
  • Spermiogenesis Associated 3 3
  • EC 2.7.11.1 4
  • EC 2.7.11 52
  • STK22D 3
  • TSK3 3

External Ids for TSSK3 Gene

Previous HGNC Symbols for TSSK3 Gene

  • STK22C

Previous GeneCards Identifiers for TSSK3 Gene

  • GC01P032497
  • GC01P032600
  • GC01P032827
  • GC01P030943

Summaries for TSSK3 Gene

Entrez Gene Summary for TSSK3 Gene

  • This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSSK3 Gene

TSSK3 (Testis Specific Serine Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot Summary for TSSK3 Gene

  • May be involved in a signaling pathway during male germ cell development or mature sperm function.

Additional gene information for TSSK3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSSK3 Gene

Genomics for TSSK3 Gene

GeneHancer (GH) Regulatory Elements for TSSK3 Gene

Promoters and enhancers for TSSK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSSK3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSSK3

Top Transcription factor binding sites by QIAGEN in the TSSK3 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • ATF-2
  • c-Jun
  • IRF-1
  • STAT1
  • STAT1alpha

Genomic Locations for TSSK3 Gene

Genomic Locations for TSSK3 Gene
chr1:32,351,521-32,364,325
(GRCh38/hg38)
Size:
12,805 bases
Orientation:
Plus strand
chr1:32,817,122-32,829,926
(GRCh37/hg19)
Size:
12,805 bases
Orientation:
Plus strand

Genomic View for TSSK3 Gene

Genes around TSSK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK3 Gene

Proteins for TSSK3 Gene

  • Protein details for TSSK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PN8-TSSK3_HUMAN
    Recommended name:
    Testis-specific serine/threonine-protein kinase 3
    Protein Accession:
    Q96PN8
    Secondary Accessions:
    • Q5TEE5

    Protein attributes for TSSK3 Gene

    Size:
    268 amino acids
    Molecular mass:
    30102 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse homolog is Stk22d.

neXtProt entry for TSSK3 Gene

Selected DME Specific Peptides for TSSK3 Gene

Q96PN8:
  • VAIKVIDK
  • TDFGFAK

Post-translational modifications for TSSK3 Gene

Other Protein References for TSSK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TSSK3 Gene

Gene Families for TSSK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TSSK3 Gene

Suggested Antigen Peptide Sequences for TSSK3 Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase 22C (TSSK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96PN8

UniProtKB/Swiss-Prot:

TSSK3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK3: view

Function for TSSK3 Gene

Molecular function for TSSK3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-168, potentially by autophosphorylation.

Enzyme Numbers (IUBMB) for TSSK3 Gene

Phenotypes From GWAS Catalog for TSSK3 Gene

Gene Ontology (GO) - Molecular Function for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS,IBA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with TSSK3: view
genes like me logo Genes that share phenotypes with TSSK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSSK3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSSK3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSK3 Gene

Localization for TSSK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSK3 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TSSK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK3 Gene

Pathways & Interactions for TSSK3 Gene

PathCards logo

SuperPathways for TSSK3 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.37
genes like me logo Genes that share pathways with TSSK3: view

Pathways by source for TSSK3 Gene

1 Qiagen pathway for TSSK3 Gene
  • Sperm Motility

Gene Ontology (GO) - Biological Process for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for SIGNOR curated interactions for TSSK3 Gene

Drugs & Compounds for TSSK3 Gene

(2) Drugs for TSSK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for TSSK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with TSSK3: view

Transcripts for TSSK3 Gene

mRNA/cDNA for TSSK3 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSSK3

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK3 Gene

No ASD Table

Relevant External Links for TSSK3 Gene

GeneLoc Exon Structure for
TSSK3

Expression for TSSK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSSK3 Gene

mRNA differential expression in normal tissues according to GTEx for TSSK3 Gene

This gene is overexpressed in Testis (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSSK3

SOURCE GeneReport for Unigene cluster for TSSK3 Gene:

Hs.512763

Evidence on tissue expression from TISSUES for TSSK3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TSSK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSK3 Gene

Orthologs for TSSK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSSK3 31 30
  • 99.63 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSSK3 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSK3 31 30
  • 94.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TSSK3 31 30
  • 94.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tssk3 17 31 30
  • 92.79 (n)
rat
(Rattus norvegicus)
Mammalia Tssk3 30
  • 92.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 24 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TSSK3 31 30
  • 75.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSSK3 31
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14305 31
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y38H8A.4 31
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN4 31
  • 12 (a)
ManyToMany
FRK1 31
  • 11 (a)
ManyToMany
-- 31
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for TSSK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK3 Gene

ENSEMBL:
Gene Tree for TSSK3 (if available)
TreeFam:
Gene Tree for TSSK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSSK3: view image

Paralogs for TSSK3 Gene

genes like me logo Genes that share paralogs with TSSK3: view

Variants for TSSK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSSK3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs35457991 - p.Ser235Leu
rs35508255 - p.Ile71Val
rs55786268 - p.Ala140Thr

Additional dbSNP identifiers (rs#s) for TSSK3 Gene

Variation tolerance for TSSK3 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSSK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSSK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK3 Gene

Disorders for TSSK3 Gene

Additional Disease Information for TSSK3

No disorders were found for TSSK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSK3 Gene

Publications for TSSK3 Gene

  1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PMID: 11597141) Visconti PE … Kopf GS (Genomics 2001) 2 3 4 23 54
  2. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. (PMID: 16336268) Bucko-Justyna M … Trzeciak L (The FEBS journal 2005) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for TSSK3 Gene

Sources for TSSK3 Gene