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Aliases for TSSK3 Gene

Aliases for TSSK3 Gene

  • Testis Specific Serine Kinase 3 2 3 5
  • Serine/Threonine-Protein Kinase 22C 3 4
  • Testis-Specific Kinase 3 3 4
  • STK22C 3 4
  • SPOGA3 3 4
  • TSSK-3 3 4
  • TSK-3 3 4
  • Serine/Threonine Kinase 22C (Spermiogenesis Associated) 2
  • Testis-Specific Serine/Threonine-Protein Kinase 3 3
  • Testis-Specific Serine/Threonine Kinase 22C 3
  • Spermiogenesis Associated 3 3
  • EC 4
  • STK22D 3
  • TSK3 3

External Ids for TSSK3 Gene

Previous HGNC Symbols for TSSK3 Gene

  • STK22C

Previous GeneCards Identifiers for TSSK3 Gene

  • GC01P032497
  • GC01P032600
  • GC01P032827
  • GC01P030943

Summaries for TSSK3 Gene

Entrez Gene Summary for TSSK3 Gene

  • This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSSK3 Gene

TSSK3 (Testis Specific Serine Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot for TSSK3 Gene

  • May be involved in a signaling pathway during male germ cell development or mature sperm function.

Additional gene information for TSSK3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK3 Gene

Genomics for TSSK3 Gene

GeneHancer (GH) Regulatory Elements for TSSK3 Gene

Promoters and enhancers for TSSK3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J032350 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 660.8 +1.2 1210 4.4 HDGF MLX ARNT ARID4B SIN3A FEZF1 ZBTB7B SLC30A9 ZNF766 ZNF207 TSSK3 LOC105378629 KHDRBS1 RBBP4 TXLNA TMEM39B ZBTB8A S100PBP DCDC2B ENSG00000224066
GH01J032362 Promoter/Enhancer 1.1 EPDnew ENCODE 650.4 +11.0 11006 1 CTCF PKNOX1 NR2F1 ZBED1 RAD21 CCNT2 POLR2B POLR2A CTBP2 RBM22 FAM229A TSSK3 LOC105378629
GH01J032349 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.8 -1818 1.3 DRAP1 FOXA2 MAX MZF1 ZNF664 ZNF316 POLR2A NR2F6 RXRA ETV5 TSSK3 LOC105378629 MARCKSL1
GH01J031924 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 85.2 -415.7 -415688 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B PUM1
GH01J032289 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 70.6 -60.2 -60202 3.8 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 ZNF610 HDAC1 SNRNP40 RBBP4 TSSK3 TXLNA KHDRBS1 TMEM39B S100PBP FAM229A DCDC2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSSK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSSK3 gene promoter:
  • ATF-2
  • c-Jun
  • AP-1
  • STAT1
  • IRF-1
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • STAT1alpha

Genomic Locations for TSSK3 Gene

Genomic Locations for TSSK3 Gene
12,805 bases
Plus strand
12,805 bases
Plus strand

Genomic View for TSSK3 Gene

Genes around TSSK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK3 Gene

Proteins for TSSK3 Gene

  • Protein details for TSSK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine/threonine-protein kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q5TEE5

    Protein attributes for TSSK3 Gene

    268 amino acids
    Molecular mass:
    30102 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • The mouse homolog is Stk22d.

neXtProt entry for TSSK3 Gene

Post-translational modifications for TSSK3 Gene

Other Protein References for TSSK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSSK3 Gene

Domains & Families for TSSK3 Gene

Gene Families for TSSK3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TSSK3 Gene

Suggested Antigen Peptide Sequences for TSSK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK3: view

Function for TSSK3 Gene

Molecular function for TSSK3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-168, potentially by autophosphorylation.

Enzyme Numbers (IUBMB) for TSSK3 Gene

Phenotypes From GWAS Catalog for TSSK3 Gene

Gene Ontology (GO) - Molecular Function for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,ISS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with TSSK3: view
genes like me logo Genes that share phenotypes with TSSK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSSK3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSSK3

Clone Products

  • Addgene plasmids for TSSK3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSK3 Gene

Localization for TSSK3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSK3 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK3 Gene

Pathways & Interactions for TSSK3 Gene

SuperPathways for TSSK3 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK3: view

Pathways by source for TSSK3 Gene

1 Qiagen pathway for TSSK3 Gene

Gene Ontology (GO) - Biological Process for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for SIGNOR curated interactions for TSSK3 Gene

Drugs & Compounds for TSSK3 Gene

(2) Drugs for TSSK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for TSSK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with TSSK3: view

Transcripts for TSSK3 Gene

mRNA/cDNA for TSSK3 Gene

Unigene Clusters for TSSK3 Gene

Testis-specific serine kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSSK3

Clone Products

  • Addgene plasmids for TSSK3

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK3 Gene

No ASD Table

Relevant External Links for TSSK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSSK3 Gene

mRNA differential expression in normal tissues according to GTEx for TSSK3 Gene

This gene is overexpressed in Testis (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of TSSK3 Gene:


SOURCE GeneReport for Unigene cluster for TSSK3 Gene:


Evidence on tissue expression from TISSUES for TSSK3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TSSK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSK3 Gene

Orthologs for TSSK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSSK3 34 33
  • 99.63 (n)
(Monodelphis domestica)
Mammalia TSSK3 34
  • 95 (a)
(Canis familiaris)
Mammalia TSSK3 34 33
  • 94.78 (n)
(Bos Taurus)
Mammalia TSSK3 34 33
  • 94.65 (n)
(Mus musculus)
Mammalia Tssk3 16 34 33
  • 92.79 (n)
(Rattus norvegicus)
Mammalia Tssk3 33
  • 92.66 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
(Gallus gallus)
Aves TSSK3 34 33
  • 75.06 (n)
(Anolis carolinensis)
Reptilia TSSK3 34
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14305 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea Y38H8A.4 34
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN4 34
  • 12 (a)
FRK1 34
  • 11 (a)
-- 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
-- 34
  • 30 (a)
Species where no ortholog for TSSK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK3 Gene

Gene Tree for TSSK3 (if available)
Gene Tree for TSSK3 (if available)
Evolutionary constrained regions (ECRs) for TSSK3: view image

Paralogs for TSSK3 Gene

Variants for TSSK3 Gene

Sequence variations from dbSNP and Humsavar for TSSK3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000068694 -- 32,362,322(+) A/G 5_prime_UTR_variant
rs1000652777 -- 32,361,200(+) G/A upstream_transcript_variant
rs1000982482 -- 32,360,986(+) C/T upstream_transcript_variant
rs1001722336 -- 32,360,696(+) G/A upstream_transcript_variant
rs1002459355 -- 32,361,849(+) G/A upstream_transcript_variant

Variation tolerance for TSSK3 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSSK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK3 Gene

Disorders for TSSK3 Gene

Additional Disease Information for TSSK3

No disorders were found for TSSK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSK3 Gene

Publications for TSSK3 Gene

  1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PMID: 11597141) Visconti PE … Kopf GS (Genomics 2001) 2 3 4 22 58
  2. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. (PMID: 16336268) Bucko-Justyna M … Trzeciak L (The FEBS journal 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for TSSK3 Gene

  • Addgene plasmids for TSSK3

Sources for TSSK3 Gene

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