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Aliases for TSPYL2 Gene

Aliases for TSPYL2 Gene

  • TSPY Like 2 2 3 5
  • Differentially-Expressed Nucleolar TGF-Beta1 Target Protein 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se20-4 3 4
  • CTCL-Associated Antigen Se20-4 3 4
  • Cell Division Autoantigen 1 3 4
  • Nuclear Protein Of 79 KDa 3 4
  • TSPY-Like Protein 2 3 4
  • DENTT 3 4
  • CDA1 3 4
  • NP79 3 4
  • TSPX 3 4
  • Cutaneous T-Cell Lymphoma-Associated Tumor Antigen Se20-4 3
  • Differentially Expressed Nucleolar TGF-Beta1 Target 3
  • CASK-Interacting Nucleosome Assembly Protein 3
  • Testis-Specific Y-Encoded-Like Protein 2 3
  • Testis-Specific Protein Y Encoded-Like 2 3
  • CTCL Tumor Antigen Se20-4 3
  • HRIHFB2216 3
  • CINAP 3
  • SE204 3
  • CTCL 3

External Ids for TSPYL2 Gene

Previous GeneCards Identifiers for TSPYL2 Gene

  • GC0XP052994
  • GC0XP053128
  • GC0XP050176
  • GC0XP053111

Summaries for TSPYL2 Gene

Entrez Gene Summary for TSPYL2 Gene

  • This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

GeneCards Summary for TSPYL2 Gene

TSPYL2 (TSPY Like 2) is a Protein Coding gene. Diseases associated with TSPYL2 include Gonadoblastoma and Iqsec2. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include rDNA binding. An important paralog of this gene is TSPYL1.

UniProtKB/Swiss-Prot for TSPYL2 Gene

  • Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

Gene Wiki entry for TSPYL2 Gene

Additional gene information for TSPYL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL2 Gene

Genomics for TSPYL2 Gene

GeneHancer (GH) Regulatory Elements for TSPYL2 Gene

Promoters and enhancers for TSPYL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI053080 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 583.7 -0.1 -112 3.4 PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A GLI4 BRCA1 POLR2B GLIS2 TSPYL2 GPR173 FAM156B KDM5C-IT1 KDM5C PHF8 KANTR ACTG1P10 SMC1A ENSG00000233250
GH0XI053084 Enhancer 0.2 ENCODE 550.8 +1.7 1725 0.1 TSPYL2 KANTR
GH0XI053223 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.3 +142.4 142375 2.9 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 KDM5C GPR173 TSPYL2 FAM156B ACTG1P10 KANTR FAM120C HUWE1 ENSG00000227329 FAM156A
GH0XI053420 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29 +340.0 339970 2.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 SMC1A RIBC1 KDM5C FAM156B TSPYL2 GPR173 ACTG1P10 KDM5C-IT1 PHF8 ENSG00000233250
GH0XI053047 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 33 -33.4 -33388 2.3 KLF1 ZSCAN4 KLF17 ZNF335 ZFHX2 GLIS2 ZNF366 POLR2A ZBTB48 KLF7 GPR173 TSPYL2 SSX8 GC0XP053024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSPYL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPYL2 gene promoter:

Genomic Locations for TSPYL2 Gene

Genomic Locations for TSPYL2 Gene
chrX:53,082,360-53,088,546
(GRCh38/hg38)
Size:
6,187 bases
Orientation:
Plus strand
chrX:53,111,542-53,117,728
(GRCh37/hg19)

Genomic View for TSPYL2 Gene

Genes around TSPYL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL2 Gene

Proteins for TSPYL2 Gene

  • Protein details for TSPYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2G4-TSYL2_HUMAN
    Recommended name:
    Testis-specific Y-encoded-like protein 2
    Protein Accession:
    Q9H2G4
    Secondary Accessions:
    • O94799
    • Q96DG7
    • Q9BZW6

    Protein attributes for TSPYL2 Gene

    Size:
    693 amino acids
    Molecular mass:
    79435 Da
    Quaternary structure:
    • Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).
    Miscellaneous:
    • Subject to X inactivation.
    • Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.
    SequenceCaution:
    • Sequence=AAG53596.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TSPYL2 Gene

Post-translational modifications for TSPYL2 Gene

  • Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
  • Ubiquitination at posLast=384384

Other Protein References for TSPYL2 Gene

No data available for DME Specific Peptides for TSPYL2 Gene

Domains & Families for TSPYL2 Gene

Gene Families for TSPYL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSPYL2 Gene

Suggested Antigen Peptide Sequences for TSPYL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2G4

UniProtKB/Swiss-Prot:

TSYL2_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL2: view

Function for TSPYL2 Gene

Molecular function for TSPYL2 Gene

UniProtKB/Swiss-Prot Function:
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
UniProtKB/Swiss-Prot Induction:
Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung cancer cells (at protein level).

Gene Ontology (GO) - Molecular Function for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding NAS 11395479
GO:0005515 protein binding IPI 26496610
genes like me logo Genes that share ontologies with TSPYL2: view
genes like me logo Genes that share phenotypes with TSPYL2: view

Animal Models for TSPYL2 Gene

MGI Knock Outs for TSPYL2:

Animal Model Products

CRISPR Products

miRNA for TSPYL2 Gene

miRTarBase miRNAs that target TSPYL2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPYL2 Gene

Localization for TSPYL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPYL2 Gene

Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPYL2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11395479
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 11395479
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSPYL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPYL2 Gene

Pathways & Interactions for TSPYL2 Gene

genes like me logo Genes that share pathways with TSPYL2: view

Gene Ontology (GO) - Biological Process for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0008156 negative regulation of DNA replication IDA 11395479
genes like me logo Genes that share ontologies with TSPYL2: view

No data available for SIGNOR curated interactions for TSPYL2 Gene

Drugs & Compounds for TSPYL2 Gene

No Compound Related Data Available

Transcripts for TSPYL2 Gene

Unigene Clusters for TSPYL2 Gene

TSPY-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - -
SP2:
SP3:
SP4: -
SP5: - - - -

Relevant External Links for TSPYL2 Gene

GeneLoc Exon Structure for
TSPYL2
ECgene alternative splicing isoforms for
TSPYL2

Expression for TSPYL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPYL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPYL2 Gene

This gene is overexpressed in Lung (41.1), Testis (9.7), and Fetal Brain (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPYL2 Gene



Protein tissue co-expression partners for TSPYL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPYL2 Gene:

TSPYL2

SOURCE GeneReport for Unigene cluster for TSPYL2 Gene:

Hs.136164

mRNA Expression by UniProt/SwissProt for TSPYL2 Gene:

Q9H2G4-TSYL2_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.

Evidence on tissue expression from TISSUES for TSPYL2 Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Blood(2.3)
  • Heart(2.1)
  • Spleen(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TSPYL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPYL2 Gene

Orthologs for TSPYL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPYL2 33
  • 85.58 (n)
-- 34
  • 31 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TSPYL2 33 34
  • 84.41 (n)
cow
(Bos Taurus)
Mammalia TSPYL2 33 34
  • 81.15 (n)
mouse
(Mus musculus)
Mammalia Tspyl2 33 16 34
  • 77.04 (n)
rat
(Rattus norvegicus)
Mammalia Tspyl2 33
  • 75.97 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TSPY2 34
  • 21 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Set 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-2 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 34
  • 26 (a)
OneToMany
Species where no ortholog for TSPYL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL2 Gene

ENSEMBL:
Gene Tree for TSPYL2 (if available)
TreeFam:
Gene Tree for TSPYL2 (if available)

Paralogs for TSPYL2 Gene

(3) SIMAP similar genes for TSPYL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPYL2: view

Variants for TSPYL2 Gene

Sequence variations from dbSNP and Humsavar for TSPYL2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs781884842 likely-benign, not specified 53,082,577(+) CCGCCGCCGCCGCCGCCGCCGC/CCGCCGCCGCCGC/CCGCCGCCGCCGCCGC/CCGCCGCCGCCGCCGCCGC/CCGCCGCCGCCGCCGCCGCCGCCGC/CCGCCGCCGCCGCCGCCGCCGCCGCCGC/CCGCCGCCGCCGCCGCCGCCGCCGCCGCCGC coding_sequence_variant, inframe_deletion, inframe_insertion, non_coding_transcript_variant
rs1000151289 -- 53,084,999(+) A/G coding_sequence_variant, intron_variant, missense_variant
rs1000479665 -- 53,084,497(+) C/A intron_variant
rs1002373876 -- 53,086,551(+) G/C 3_prime_UTR_variant, intron_variant
rs1002926853 -- 53,082,587(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPYL2 Gene

Variant ID Type Subtype PubMed ID
nsv508773 CNV insertion 20534489
nsv435891 CNV deletion 17901297
esv2740175 CNV deletion 23290073

Variation tolerance for TSPYL2 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPYL2 Gene

Human Gene Mutation Database (HGMD)
TSPYL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPYL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPYL2 Gene

Disorders for TSPYL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSPYL2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gonadoblastoma
  • gby
iqsec2
  • iqsec2-related epilepsy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPYL2

genes like me logo Genes that share disorders with TSPYL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPYL2 Gene

Publications for TSPYL2 Gene

  1. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. (PMID: 11395479) Chai Z … Toh BH (The Journal of biological chemistry 2001) 2 3 4 58
  2. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. (PMID: 11318608) Ozbun LL … Jakowlew SB (Genomics 2001) 2 3 4 58
  3. Identification of a homozygous missense mutation in LRP2 and a hemizygous missense mutation in TSPYL2 in a family with mild intellectual disability. (PMID: 26529358) Vasli N … John P (Psychiatric genetics 2016) 3 4 58
  4. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. (PMID: 18381359) Kandalaft LE … Jakowlew SB (Carcinogenesis 2008) 3 22 58
  5. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. (PMID: 17317670) Tu Y … Chai Z (The Journal of biological chemistry 2007) 3 4 58

Products for TSPYL2 Gene

Sources for TSPYL2 Gene

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