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Aliases for TSPY4 Gene

Aliases for TSPY4 Gene

  • Testis Specific Protein, Y-Linked 4 2 3 5
  • Testis-Specific Y-Encoded Protein 4 3
  • TSPY10 3
  • TSPY8 3

External Ids for TSPY4 Gene

Previous GeneCards Identifiers for TSPY4 Gene

  • GC0YP009236
  • GC0YP009176

Summaries for TSPY4 Gene

GeneCards Summary for TSPY4 Gene

TSPY4 (Testis Specific Protein, Y-Linked 4) is a Protein Coding gene. An important paralog of this gene is TSPY10.

UniProtKB/Swiss-Prot for TSPY4 Gene

  • Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Additional gene information for TSPY4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY4 Gene

Genomics for TSPY4 Gene

Genomic Locations for TSPY4 Gene

Genomic Locations for TSPY4 Gene
2,821 bases
Plus strand

Genomic View for TSPY4 Gene

Genes around TSPY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY4 Gene

No data available for GeneHancer (GH) Regulatory Elements for TSPY4 Gene

Proteins for TSPY4 Gene

  • Protein details for TSPY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded protein 4
    Protein Accession:

    Protein attributes for TSPY4 Gene

    314 amino acids
    Molecular mass:
    35727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY4 Gene

Post-translational modifications for TSPY4 Gene

No Post-translational modifications

Other Protein References for TSPY4 Gene

No data available for DME Specific Peptides for TSPY4 Gene

Domains & Families for TSPY4 Gene

Gene Families for TSPY4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSPY4 Gene


Suggested Antigen Peptide Sequences for TSPY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY4: view

Function for TSPY4 Gene

Molecular function for TSPY4 Gene

UniProtKB/Swiss-Prot Function:
Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPY4 Gene

Localization for TSPY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPY4 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSPY4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPY4 Gene

Pathways & Interactions for TSPY4 Gene

SuperPathways for TSPY4 Gene

No Data Available

Interacting Proteins for TSPY4 Gene

Gene Ontology (GO) - Biological Process for TSPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007506 gonadal mesoderm development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSPY4: view

No data available for Pathways by source and SIGNOR curated interactions for TSPY4 Gene

Drugs & Compounds for TSPY4 Gene

No Compound Related Data Available

Transcripts for TSPY4 Gene

mRNA/cDNA for TSPY4 Gene

(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY4 Gene

No ASD Table

Relevant External Links for TSPY4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPY4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPY4 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY4 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of TSPY4 Gene:

genes like me logo Genes that share expression patterns with TSPY4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPY4 Gene

Orthologs for TSPY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
LOC101059018 33
  • 88.51 (n)
(Bos Taurus)
Mammalia -- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
TSPY-M2 34 34 34
  • 35 (a)
-- 34
  • 33 (a)
-- 34
  • 31 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
(Canis familiaris)
Mammalia -- 34
  • 33 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
(Danio rerio)
Actinopterygii TSPY2 34
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea spr-2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 34
  • 19 (a)
Species where no ortholog for TSPY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY4 Gene

Gene Tree for TSPY4 (if available)
Gene Tree for TSPY4 (if available)

Paralogs for TSPY4 Gene

Paralogs for TSPY4 Gene

(16) SIMAP similar genes for TSPY4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSPY4: view

Variants for TSPY4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY4 Gene

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).

Sequence variations from dbSNP and Humsavar for TSPY4 Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs368120091 -- 9,339,857(+) T/C intron_variant
rs3876329 -- 9,340,133(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs4044229 -- 9,340,318(+) G/C downstream_transcript_variant
rs562494659 -- 9,335,949(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPY4 Gene

Variant ID Type Subtype PubMed ID
nsv1077607 CNV duplication 25765185
nsv1077608 CNV duplication 25765185
nsv1115925 CNV duplication 24896259
nsv1115926 CNV duplication 24896259
nsv1149597 CNV duplication 26484159
nsv1151272 CNV duplication 26484159
nsv7473 OTHER inversion 18451855
nsv953732 CNV duplication 24416366
nsv953735 CNV duplication 24416366

Additional Variant Information for TSPY4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Variation tolerance for TSPY4 Gene

Disorders for TSPY4 Gene

Additional Disease Information for TSPY4

No disorders were found for TSPY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPY4 Gene

Publications for TSPY4 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TSPY4 Gene

Sources for TSPY4 Gene

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