Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPY10 Gene

Aliases for TSPY10 Gene

  • Testis Specific Protein, Y-Linked 10 2 3 5

External Ids for TSPY10 Gene

Previous GeneCards Identifiers for TSPY10 Gene

  • GC00U926456
  • GC0YP009365

Summaries for TSPY10 Gene

GeneCards Summary for TSPY10 Gene

TSPY10 (Testis Specific Protein, Y-Linked 10) is a Protein Coding gene. Diseases associated with TSPY10 include Persistent Mullerian Duct Syndrome. An important paralog of this gene is TSPY4.

UniProtKB/Swiss-Prot for TSPY10 Gene

  • Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Additional gene information for TSPY10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY10 Gene

Genomics for TSPY10 Gene

GeneHancer (GH) Regulatory Elements for TSPY10 Gene

Promoters and enhancers for TSPY10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI009527 Promoter 0.5 EPDnew 550.8 +0.0 44 0.1 FAM197Y2 TSPY10 FAM197Y1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSPY10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSPY10 Gene

Genomic Locations for TSPY10 Gene
2,804 bases
Plus strand

Genomic View for TSPY10 Gene

Genes around TSPY10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPY10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY10 Gene

Proteins for TSPY10 Gene

  • Protein details for TSPY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded protein 10
    Protein Accession:

    Protein attributes for TSPY10 Gene

    314 amino acids
    Molecular mass:
    35727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY10 Gene

Post-translational modifications for TSPY10 Gene

No Post-translational modifications

Other Protein References for TSPY10 Gene

No data available for DME Specific Peptides for TSPY10 Gene

Domains & Families for TSPY10 Gene

Gene Families for TSPY10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSPY10 Gene


Suggested Antigen Peptide Sequences for TSPY10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY10: view

Function for TSPY10 Gene

Molecular function for TSPY10 Gene

UniProtKB/Swiss-Prot Function:
Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPY10 Gene

Localization for TSPY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPY10 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TSPY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSPY10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPY10 Gene

Pathways & Interactions for TSPY10 Gene

SuperPathways for TSPY10 Gene

No Data Available

Interacting Proteins for TSPY10 Gene

Gene Ontology (GO) - Biological Process for TSPY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007283 spermatogenesis IEA --
GO:0007506 gonadal mesoderm development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSPY10: view

No data available for Pathways by source and SIGNOR curated interactions for TSPY10 Gene

Drugs & Compounds for TSPY10 Gene

No Compound Related Data Available

Transcripts for TSPY10 Gene

mRNA/cDNA for TSPY10 Gene

(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY10 Gene

No ASD Table

Relevant External Links for TSPY10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPY10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPY10 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY10 Gene

This gene is overexpressed in Testis (x53.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPY10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPY10 Gene:


Evidence on tissue expression from TISSUES for TSPY10 Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with TSPY10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPY10 Gene

Orthologs for TSPY10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
LOC101059018 33
  • 88.74 (n)
(Bos Taurus)
Mammalia -- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
TSPY-M2 34 34 34
  • 35 (a)
-- 34
  • 33 (a)
-- 34
  • 31 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
(Canis familiaris)
Mammalia -- 34
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
(Danio rerio)
Actinopterygii TSPY2 34
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea spr-2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 34
  • 19 (a)
Species where no ortholog for TSPY10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY10 Gene

Gene Tree for TSPY10 (if available)
Gene Tree for TSPY10 (if available)

Paralogs for TSPY10 Gene

Paralogs for TSPY10 Gene

(16) SIMAP similar genes for TSPY10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPY10: view

Variants for TSPY10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY10 Gene

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).

Sequence variations from dbSNP and Humsavar for TSPY10 Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs111378692 -- 9,526,489(+) A/C upstream_transcript_variant
rs199621556 -- 9,529,367(+) A/G intron_variant
rs199968266 -- 9,526,785(+) A/C upstream_transcript_variant
rs201273083 -- 9,526,789(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPY10 Gene

Variant ID Type Subtype PubMed ID
nsv1077607 CNV duplication 25765185
nsv1077608 CNV duplication 25765185
nsv1115925 CNV duplication 24896259
nsv1115926 CNV duplication 24896259
nsv1149597 CNV duplication 26484159
nsv1151272 CNV duplication 26484159
nsv7473 OTHER inversion 18451855
nsv953732 CNV duplication 24416366
nsv953733 CNV duplication 24416366
nsv953735 CNV duplication 24416366
nsv953737 CNV duplication 24416366

Additional Variant Information for TSPY10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Variation tolerance for TSPY10 Gene

Disorders for TSPY10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPY10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
persistent mullerian duct syndrome
  • pmds
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPY10

genes like me logo Genes that share disorders with TSPY10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPY10 Gene

Publications for TSPY10 Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TSPY10 Gene

Sources for TSPY10 Gene

Loading form....