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TSPOAP1 (TSPO Associated Protein 1) is a Protein Coding gene. Diseases associated with TSPOAP1 include Fuchs' Endothelial Dystrophy. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. An important paralog of this gene is RIMBP3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21078624 |
GO:0030156 | benzodiazepine receptor binding | IPI | 9915832 |
GO:0099626 | voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA,IBA | 9915832 |
GO:0005739 | mitochondrion | IDA,IBA | 9915832 |
GO:0005829 | cytosol | TAS | -- |
GO:0044305 | calyx of Held | IEA | -- |
GO:0098978 | glutamatergic synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neurotransmitter Release Cycle | ||
2 | Transmission across Chemical Synapses |
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3 | Benzodiazepine Pathway, Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006700 | C21-steroid hormone biosynthetic process | TAS | -- |
GO:0007269 | neurotransmitter secretion | TAS | -- |
GO:0007274 | NOT neuromuscular synaptic transmission | IBA | 21873635 |
GO:0008150 | biological_process | ND | -- |
GO:0014047 | glutamate secretion | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | BZRAP1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | BZRAP1 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | BZRAP1 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Bzrap1 32 |
|
||
mouse (Mus musculus) |
Mammalia | Bzrap1 33 32 |
|
OneToOne | |
Tspoap1 17 |
|
||||
oppossum (Monodelphis domestica) |
Mammalia | BZRAP1 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | BZRAP1 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | BZRAP1 32 |
|
||
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | bzrap1 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rimbp2 33 |
|
ManyToMany | |
fruit fly (Drosophila melanogaster) |
Insecta | Rbp 33 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | tag-168 33 |
|
OneToMany |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs61741210 | benign, not specified | 58,309,371(-) | C/T | coding_sequence_variant, missense_variant | |
rs61743284 | benign, not specified | 58,327,685(-) | C/T | coding_sequence_variant, missense_variant | |
rs1000021468 | -- | 58,324,445(-) | C/A/T | intron_variant | |
rs1000027554 | -- | 58,313,529(-) | T/G | intron_variant | |
rs1000032783 | -- | 58,322,017(-) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv2109 | CNV | deletion | 18451855 |
nsv457859 | CNV | loss | 19166990 |
nsv457860 | CNV | loss | 19166990 |
nsv470593 | CNV | loss | 18288195 |
nsv509663 | CNV | insertion | 20534489 |
nsv517229 | CNV | gain+loss | 19592680 |
nsv575798 | CNV | loss | 21841781 |
nsv575799 | CNV | loss | 21841781 |
nsv952349 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fuchs' endothelial dystrophy |
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