Aliases for TSPO Gene
External Ids for TSPO Gene
Previous HGNC Symbols for TSPO Gene
Previous GeneCards Identifiers for TSPO Gene
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
GeneCards Summary for TSPO Gene
TSPO (Translocator Protein) is a Protein Coding gene. Diseases associated with TSPO include Hepatic Encephalopathy and Focal Epilepsy. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include cholesterol binding and androgen binding. An important paralog of this gene is TSPO2.
UniProtKB/Swiss-Prot for TSPO Gene
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).