The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternat... See more...

Aliases for TSPAN9 Gene

Aliases for TSPAN9 Gene

  • Tetraspanin 9 2 3 5
  • Tetraspan NET-5 3 4
  • Tetraspanin-9 3 4
  • Tspan-9 3 4
  • NET-5 2 3
  • NET5 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-5 3
  • New EST Tetraspan 5 3
  • PP1057 3
  • TSPAN9 5

External Ids for TSPAN9 Gene

Previous GeneCards Identifiers for TSPAN9 Gene

  • GC12P003057
  • GC12P003186

Summaries for TSPAN9 Gene

Entrez Gene Summary for TSPAN9 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for TSPAN9 Gene

TSPAN9 (Tetraspanin 9) is a Protein Coding gene. Diseases associated with TSPAN9 include Fallopian Tube Carcinoma. An important paralog of this gene is TSPAN4.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN9 Gene

Genomics for TSPAN9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TSPAN9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J003076 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 626.2 +0.1 146 2.6 HNRNPL ZNF629 ZNF692 ZNF776 ZIC2 ZSCAN4 RBFOX2 PATZ1 SP1 ZNF501 TSPAN9 lnc-TEAD4-3 piR-53431-099 PRMT8
GH12J003199 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 605.7 +123.9 123946 4.2 CTCF PRDM10 ZNF692 ZNF143 ZIC2 POLR2A PATZ1 RAD21 ZNF740 TRIM22 TSPAN9 lnc-FOXM1-3 lnc-TEAD4-5 PRMT8
GH12J003070 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 608.5 -6.1 -6121 1.7 TFAP4 TEAD3 NRF1 TSPAN9 ENSG00000234589 HSALNG0088631 RF00017-1072 RPL13AP24 piR-46238-004 NRIP2 HSALNG0088628 TEAD4
GH12J003075 Enhancer 0.2 Ensembl 608.7 -1.9 -1854 0.2 TSPAN9 lnc-TEAD4-3 RF00017-1072 TEAD4
GH12J003115 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 28.6 +43.0 43046 9.2 ZBTB33 SP1 ZNF341 SCRT2 CEBPB CTCF FOS POLR2A PKNOX1 NR2F2 TSPAN9 ENSG00000278469 piR-43099-098 PRMT8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN9

Top Transcription factor binding sites by QIAGEN in the TSPAN9 gene promoter:
  • AML1a
  • AREB6
  • E47
  • FOXO3
  • FOXO3a
  • FOXO3b
  • LCR-F1
  • POU6F1 (c2)
  • RSRFC4
  • Tal-1beta

Genomic Locations for TSPAN9 Gene

Genomic Locations for TSPAN9 Gene
chr12:3,077,355-3,286,564
(GRCh38/hg38)
Size:
209,210 bases
Orientation:
Plus strand
chr12:3,186,521-3,395,730
(GRCh37/hg19)
Size:
209,210 bases
Orientation:
Plus strand

Genomic View for TSPAN9 Gene

Genes around TSPAN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN9 Gene

Proteins for TSPAN9 Gene

  • Protein details for TSPAN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75954-TSN9_HUMAN
    Recommended name:
    Tetraspanin-9
    Protein Accession:
    O75954
    Secondary Accessions:
    • D3DUQ7
    • Q53FV2
    • Q6FGJ8

    Protein attributes for TSPAN9 Gene

    Size:
    239 amino acids
    Molecular mass:
    26779 Da
    Quaternary structure:
    • Found in a complex with GP6.

neXtProt entry for TSPAN9 Gene

Post-translational modifications for TSPAN9 Gene

No data available for DME Specific Peptides for TSPAN9 Gene

Domains & Families for TSPAN9 Gene

Gene Families for TSPAN9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN9 Gene

InterPro:
Blocks:
  • Transmembrane four family signature
ProtoNet:

Suggested Antigen Peptide Sequences for TSPAN9 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspan NET-5 (TSN9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75954

UniProtKB/Swiss-Prot:

TSN9_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN9: view

Function for TSPAN9 Gene

Phenotypes From GWAS Catalog for TSPAN9 Gene

Gene Ontology (GO) - Molecular Function for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSPAN9: view
genes like me logo Genes that share phenotypes with TSPAN9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN9

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN9 Gene

Localization for TSPAN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN9 Gene

Membrane. Multi-pass membrane protein. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN9 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18795891
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN9: view

Pathways & Interactions for TSPAN9 Gene

PathCards logo

SuperPathways for TSPAN9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TSPAN9: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN9 Gene

Drugs & Compounds for TSPAN9 Gene

No Compound Related Data Available

Transcripts for TSPAN9 Gene

mRNA/cDNA for TSPAN9 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN9

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN9 Gene

No ASD Table

Relevant External Links for TSPAN9 Gene

GeneLoc Exon Structure for
TSPAN9

Expression for TSPAN9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN9 Gene

This gene is overexpressed in Brain - Cerebellum (x5.1), Brain - Cerebellar Hemisphere (x4.7), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for TSPAN9 Gene

This gene is overexpressed in Bone (12.4) and Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN9 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN9

SOURCE GeneReport for Unigene cluster for TSPAN9 Gene:

Hs.504517

mRNA Expression by UniProt/SwissProt for TSPAN9 Gene:

O75954-TSN9_HUMAN
Tissue specificity: Expressed in megakaryocytes and platelets (at protein level).

Evidence on tissue expression from TISSUES for TSPAN9 Gene

  • Pancreas(4.2)
  • Heart(2.6)
  • Nervous system(2.6)
  • Muscle(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with TSPAN9: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN9 Gene

Orthologs for TSPAN9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN9 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia TSPAN9 30 31
  • 94.14 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia TSPAN9 30 31
  • 91.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tspan9 30
  • 90.38 (n)
Mouse
(Mus musculus)
Mammalia Tspan9 30 17 31
  • 90.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TSPAN9 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia TSPAN9 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TSPAN9 30 31
  • 77.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TSPAN9 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tspan9 30
  • 79.92 (n)
Zebrafish
(Danio rerio)
Actinopterygii tspan9b 31
  • 77 (a)
OneToMany
tspan9a 30 31
  • 75.87 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13798 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tsp5D 30 31
  • 50.45 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007373 30
  • 50 (n)
Worm
(Caenorhabditis elegans)
Secernentea tsp-8 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for TSPAN9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TSPAN9 Gene

ENSEMBL:
Gene Tree for TSPAN9 (if available)
TreeFam:
Gene Tree for TSPAN9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSPAN9: view image

Paralogs for TSPAN9 Gene

(20) SIMAP similar genes for TSPAN9 Gene using alignment to 3 proteins:

  • TSN9_HUMAN
  • B5MD23_HUMAN
  • E9PHL0_HUMAN
genes like me logo Genes that share paralogs with TSPAN9: view

Variants for TSPAN9 Gene

Additional dbSNP identifiers (rs#s) for TSPAN9 Gene

Structural Variations from Database of Genomic Variants (DGV) for TSPAN9 Gene

Variant ID Type Subtype PubMed ID
dgv1345n100 CNV gain 25217958
dgv2292n54 CNV loss 21841781
dgv2293n54 CNV loss 21841781
dgv2294n54 CNV loss 21841781
dgv2295n54 CNV loss 21841781
dgv741e59 CNV duplication 20981092
dgv742e59 CNV duplication 20981092
dgv753n106 CNV deletion 24896259
esv1000555 CNV deletion 20482838
esv1080066 CNV insertion 17803354
esv1506846 CNV insertion 17803354
esv1628800 CNV deletion 17803354
esv2657581 CNV deletion 23128226
esv2673166 CNV deletion 23128226
esv27287 CNV gain 19812545
esv2745427 CNV deletion 23290073
esv2745428 CNV deletion 23290073
esv2745429 CNV deletion 23290073
esv2745431 CNV deletion 23290073
esv2745432 CNV deletion 23290073
esv2745433 CNV deletion 23290073
esv2745434 CNV deletion 23290073
esv2761722 CNV gain 21179565
esv29653 CNV loss 19812545
esv3548648 CNV deletion 23714750
esv3580361 CNV gain 25503493
esv3628339 CNV loss 21293372
esv3628340 CNV loss 21293372
esv3628341 CNV loss 21293372
esv3628342 CNV loss 21293372
esv4288 CNV loss 18987735
esv8687 CNV loss 19470904
nsv1048174 CNV gain 25217958
nsv1068058 CNV deletion 25765185
nsv1071002 CNV deletion 25765185
nsv1126308 CNV deletion 24896259
nsv1147991 CNV deletion 26484159
nsv468976 CNV loss 19166990
nsv468977 CNV loss 19166990
nsv468978 CNV loss 19166990
nsv472896 CNV novel sequence insertion 20440878
nsv472904 CNV novel sequence insertion 20440878
nsv483060 CNV loss 15286789
nsv516931 CNV loss 19592680
nsv526531 CNV loss 19592680
nsv527090 CNV loss 19592680
nsv527091 CNV loss 19592680
nsv528150 CNV loss 19592680
nsv53179 CNV deletion 16902084
nsv557084 CNV loss 21841781
nsv557085 CNV loss 21841781
nsv557089 CNV gain 21841781
nsv557096 CNV loss 21841781
nsv557101 CNV loss 21841781
nsv557105 CNV loss 21841781
nsv557106 CNV loss 21841781
nsv557107 CNV loss 21841781
nsv557110 CNV loss 21841781
nsv557111 CNV loss 21841781
nsv557112 CNV loss 21841781
nsv557113 CNV loss 21841781
nsv557114 CNV gain 21841781
nsv821042 CNV deletion 20802225
nsv821465 CNV deletion 20802225
nsv832312 CNV loss 17160897
nsv8890 CNV loss 18304495
nsv8892 CNV loss 18304495
nsv976556 CNV duplication 23825009

Variation tolerance for TSPAN9 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN9 Gene

Disorders for TSPAN9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fallopian tube carcinoma
  • cancer of the fallopian tube
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPAN9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TSPAN9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN9 Gene

Publications for TSPAN9 Gene

  1. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V … Rubinstein E (Biochimica et biophysica acta 2000) 2 3 4
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 41
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41
  4. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PMID: 18795891) Protty MB … Tomlinson MG (The Biochemical journal 2009) 3 4
  5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 41

Products for TSPAN9 Gene

Sources for TSPAN9 Gene