The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This enc... See more...

Aliases for TSPAN8 Gene

Aliases for TSPAN8 Gene

  • Tetraspanin 8 2 3 5
  • Transmembrane 4 Superfamily Member 3 2 3 4
  • Tumor-Associated Antigen CO-029 3 4
  • Tetraspanin-8 3 4
  • Tspan-8 3 4
  • CO-029 2 3
  • TM4SF3 3 4
  • TSPAN8 5

External Ids for TSPAN8 Gene

Previous HGNC Symbols for TSPAN8 Gene

  • TM4SF3

Previous GeneCards Identifiers for TSPAN8 Gene

  • GC12M069806
  • GC12M071518
  • GC12M068568

Summaries for TSPAN8 Gene

Entrez Gene Summary for TSPAN8 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN8 Gene

TSPAN8 (Tetraspanin 8) is a Protein Coding gene. Diseases associated with TSPAN8 include Pancreas, Annular and Maturity-Onset Diabetes Of The Young. Among its related pathways are Extracellular vesicle-mediated signaling in recipient cells. An important paralog of this gene is TSPAN4.

Gene Wiki entry for TSPAN8 Gene

Additional gene information for TSPAN8 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN8 Gene

Genomics for TSPAN8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TSPAN8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J071152 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 609.2 +282.8 282787 13.4 CREB1 GATAD2A REST SOX13 RCOR2 RBFOX2 RXRB IRF2 SP1 CEBPA TSPAN8 ENSG00000258053 piR-53063-047 piR-33432-124 lnc-PTPRR-3 PTPRR LGR5
GH12J071438 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.4 1402 3.6 CEBPG HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 LEF1 SOX13 LGR5 TSPAN8 ZFC3H1
GH12J071469 Enhancer 0.9 Ensembl ENCODE 12.3 -26.9 -26919 2 ZNF629 IKZF1 JUND PKNOX1 ZNF600 EGR1 ZXDB CEBPB FOXK2 FOS TSPAN8 LGR5 ENSG00000277223 HSALNG0092342 THAP2
GH12J071415 Enhancer 0.6 ENCODE 11.5 +26.1 26082 0.2 CEBPG CTCF REST RAD21 TRIM22 CEBPA MAFF SMC3 GATA3 ZNF654 LGR5 TSPAN8 ENSG00000212461 piR-47162-036 PTPRR
GH12J070691 Enhancer 0.9 FANTOM5 Ensembl ENCODE 4.5 +750.1 750097 2.8 CTCF SP1 JUND NR2F2 RAD21 SMC3 RXRA JUN PTPRB TSPAN8 piR-38352-125 FAHD2P1 PTPRR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN8

Top Transcription factor binding sites by QIAGEN in the TSPAN8 gene promoter:
  • Bach2
  • E47
  • FAC1
  • LCR-F1
  • LyF-1
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for TSPAN8 Gene

Genomic Locations for TSPAN8 Gene
chr12:71,125,085-71,441,898
(GRCh38/hg38)
Size:
316,814 bases
Orientation:
Minus strand
chr12:71,518,865-71,835,678
(GRCh37/hg19)
Size:
316,814 bases
Orientation:
Minus strand

Genomic View for TSPAN8 Gene

Genes around TSPAN8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN8 Gene

Proteins for TSPAN8 Gene

  • Protein details for TSPAN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19075-TSN8_HUMAN
    Recommended name:
    Tetraspanin-8
    Protein Accession:
    P19075
    Secondary Accessions:
    • B2R7T7
    • Q9BS78

    Protein attributes for TSPAN8 Gene

    Size:
    237 amino acids
    Molecular mass:
    26044 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN8 Gene

Post-translational modifications for TSPAN8 Gene

  • Glycosylation at Asn118
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN8 Gene

No data available for DME Specific Peptides for TSPAN8 Gene

Domains & Families for TSPAN8 Gene

Gene Families for TSPAN8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for TSPAN8 Gene

InterPro:
Blocks:
  • Transmembrane four family signature
ProtoNet:

Suggested Antigen Peptide Sequences for TSPAN8 Gene

GenScript: Design optimal peptide antigens:
  • Tumor-associated antigen CO-029 (TSN8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P19075

UniProtKB/Swiss-Prot:

TSN8_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN8: view

Function for TSPAN8 Gene

Phenotypes From GWAS Catalog for TSPAN8 Gene

Gene Ontology (GO) - Molecular Function for TSPAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 27180358
genes like me logo Genes that share ontologies with TSPAN8: view
genes like me logo Genes that share phenotypes with TSPAN8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN8

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN8

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN8 Gene

Localization for TSPAN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN8 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN8 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 3
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with TSPAN8: view

Pathways & Interactions for TSPAN8 Gene

genes like me logo Genes that share pathways with TSPAN8: view

Pathways by source for TSPAN8 Gene

Gene Ontology (GO) - Biological Process for TSPAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0010468 regulation of gene expression IEA --
GO:0030195 negative regulation of blood coagulation IEA --
genes like me logo Genes that share ontologies with TSPAN8: view

No data available for SIGNOR curated interactions for TSPAN8 Gene

Drugs & Compounds for TSPAN8 Gene

No Compound Related Data Available

Transcripts for TSPAN8 Gene

mRNA/cDNA for TSPAN8 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN8 Gene

No ASD Table

Relevant External Links for TSPAN8 Gene

GeneLoc Exon Structure for
TSPAN8

Expression for TSPAN8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN8 Gene

This gene is overexpressed in Colon - Transverse (x22.4), Small Intestine - Terminal Ileum (x8.7), and Stomach (x6.0).

Protein differential expression in normal tissues from HIPED for TSPAN8 Gene

This gene is overexpressed in Nasal epithelium (33.9) and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN8

SOURCE GeneReport for Unigene cluster for TSPAN8 Gene:

Hs.170563

mRNA Expression by UniProt/SwissProt for TSPAN8 Gene:

P19075-TSN8_HUMAN
Tissue specificity: Gastric, colon, rectal, and pancreatic carcinomas.

Evidence on tissue expression from TISSUES for TSPAN8 Gene

  • Intestine(4.9)
  • Liver(4.5)
  • Stomach(3.9)
  • Pancreas(3.1)
  • Muscle(2.4)
  • Kidney(2.2)
  • Gall bladder(2.1)
  • Lung(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with TSPAN8: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN8 Gene

Orthologs for TSPAN8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TSPAN8 30 31
  • 98.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TSPAN8 30 31
  • 81.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tspan8 30
  • 75.04 (n)
Mouse
(Mus musculus)
Mammalia Tspan8 30 17 31
  • 73.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TSPAN8 30 31
  • 72.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN8 31
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TSPAN8 30 31
  • 62.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TSPAN8 31
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tspan8 30
  • 60.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia tm4sf3-prov 30
Zebrafish
(Danio rerio)
Actinopterygii tspan4b 31
  • 30 (a)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8588 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tsp5D 31
  • 20 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tsp-8 31
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
OneToMany
Species where no ortholog for TSPAN8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TSPAN8 Gene

ENSEMBL:
Gene Tree for TSPAN8 (if available)
TreeFam:
Gene Tree for TSPAN8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSPAN8: view image

Paralogs for TSPAN8 Gene

(20) SIMAP similar genes for TSPAN8 Gene using alignment to 2 proteins:

  • TSN8_HUMAN
  • F8VWH2_HUMAN
genes like me logo Genes that share paralogs with TSPAN8: view

Variants for TSPAN8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN8 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
710022 Benign: not provided 71,144,171(-) C/T MISSENSE_VARIANT
710174 Benign: not provided 71,139,812(-) C/T MISSENSE_VARIANT
779949 Benign: not provided 71,125,393(-) G/A INTRON_VARIANT
779950 Benign: not provided 71,139,714(-) C/T SYNONYMOUS_VARIANT
779951 Benign: not provided 71,139,801(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TSPAN8 Gene

Structural Variations from Database of Genomic Variants (DGV) for TSPAN8 Gene

Variant ID Type Subtype PubMed ID
dgv2697n54 CNV loss 21841781
dgv294n67 CNV loss 20364138
dgv829n106 OTHER inversion 24896259
esv1243916 CNV insertion 17803354
esv24361 CNV loss 19812545
esv2515057 OTHER inversion 19546169
esv2569493 CNV insertion 19546169
esv2746033 CNV deletion 23290073
esv2746034 CNV deletion 23290073
esv2746035 CNV deletion 23290073
esv3340840 CNV insertion 20981092
esv3549373 CNV deletion 23714750
esv7710 OTHER inversion 19470904
nsv1078883 OTHER inversion 25765185
nsv1140291 OTHER inversion 24896259
nsv1144635 CNV deletion 24896259
nsv1160043 CNV duplication 26073780
nsv1160044 OTHER complex 26073780
nsv559293 CNV loss 21841781
nsv559294 CNV loss 21841781
nsv821005 CNV duplication 20802225
nsv832450 CNV gain 17160897

Variation tolerance for TSPAN8 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.90; 94.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN8 Gene

Human Gene Mutation Database (HGMD)
TSPAN8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN8 Gene

Disorders for TSPAN8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSPAN8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pancreas, annular
  • annular pancreas
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPAN8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TSPAN8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN8 Gene

Publications for TSPAN8 Gene

  1. Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. (PMID: 2395876) Szala S … Linnenbach AJ (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PMID: 20161779) Wen J … Hu R (PloS one 2010) 3 41
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 41
  5. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. (PMID: 19833888) Simonis-Bik AM … 't Hart LM (Diabetes 2010) 3 41

Products for TSPAN8 Gene

Sources for TSPAN8 Gene