The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternat... See more...

Aliases for TSPAN2 Gene

Aliases for TSPAN2 Gene

  • Tetraspanin 2 2 3 5
  • Tetraspan NET-3 3 4
  • Tetraspanin-2 3 4
  • Tetraspanin 2 Isoform 3
  • New EST Tetraspan 3 3
  • Tetraspan TM4SF 3
  • Tetraspan 2 3
  • TSPAN-2 3
  • Tspan-2 4
  • NET3 3
  • TSN2 3

External Ids for TSPAN2 Gene

Previous GeneCards Identifiers for TSPAN2 Gene

  • GC01M115303
  • GC01M115590
  • GC01M113448

Summaries for TSPAN2 Gene

Entrez Gene Summary for TSPAN2 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for TSPAN2 Gene

TSPAN2 (Tetraspanin 2) is a Protein Coding gene. Diseases associated with TSPAN2 include Migraine With Or Without Aura 1. An important paralog of this gene is CD9.

UniProtKB/Swiss-Prot Summary for TSPAN2 Gene

  • May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Gene Wiki entry for TSPAN2 Gene

Additional gene information for TSPAN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN2 Gene

Genomics for TSPAN2 Gene

GeneHancer (GH) Regulatory Elements for TSPAN2 Gene

Promoters and enhancers for TSPAN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J115088 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.6 -0.1 -112 2.8 CTCF USF1 ZNF10 ZIC2 ZBTB10 ZNF423 ZBTB26 TRIM28 ZNF341 POLR2A TSPAN2 LINC01765
GH01J115087 Promoter/Enhancer 0.7 Ensembl dbSUPER 500.7 +1.6 1602 0.2 TRIM28 SETDB1 TSPAN2 HSALNG0006257
GH01J114506 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.3 +579.1 579098 5.6 ZBTB40 EP300 SIN3A NRF1 MYC POLR2G SP1 BCLAF1 GTF2E2 PHF8 TRIM33 lnc-SYCP1-4 TSPAN2 SIKE1 AP4B1 OLFML3 RSBN1 TSHB BCAS2 piR-50444-030
GH01J115061 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 19.8 +26.6 26589 2.3 CTCF JUND ZFX REST EP300 CREB1 POLR2A FOS SRF NR3C1 TSPAN2 TSHB AMPD1 BCAS2 SIKE1 HSALNG0006257 piR-56341-004
GH01J115056 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.4 +32.7 32702 2 TEAD4 EP300 BCL11A POLR2A NR3C1 ARNT NBN BATF MAFK EBF1 lnc-NGF-2 TSPAN2 TSHB AMPD1 HSALNG0006251
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN2

Top Transcription factor binding sites by QIAGEN in the TSPAN2 gene promoter:
  • FOXD3
  • LUN-1
  • Max1
  • MAZR
  • NRSF form 1
  • NRSF form 2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • POU6F1 (c2)

Genomic Locations for TSPAN2 Gene

Genomic Locations for TSPAN2 Gene
chr1:115,048,011-115,089,503
(GRCh38/hg38)
Size:
41,493 bases
Orientation:
Minus strand
chr1:115,590,632-115,632,121
(GRCh37/hg19)
Size:
41,490 bases
Orientation:
Minus strand

Genomic View for TSPAN2 Gene

Genes around TSPAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN2 Gene

Proteins for TSPAN2 Gene

  • Protein details for TSPAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60636-TSN2_HUMAN
    Recommended name:
    Tetraspanin-2
    Protein Accession:
    O60636
    Secondary Accessions:
    • D6PTH4
    • Q5TET2
    • Q8WU05

    Protein attributes for TSPAN2 Gene

    Size:
    221 amino acids
    Molecular mass:
    24148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN2 Gene

Post-translational modifications for TSPAN2 Gene

  • Glycosylation at Asn139
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN2 Gene

No data available for DME Specific Peptides for TSPAN2 Gene

Domains & Families for TSPAN2 Gene

Gene Families for TSPAN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN2 Gene

Blocks:
  • Transmembrane four family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPAN2 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspanin 2 (B1AKP2_HUMAN)
  • Tetraspan NET-3 (TSN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60636

UniProtKB/Swiss-Prot:

TSN2_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN2: view

Function for TSPAN2 Gene

Molecular function for TSPAN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Phenotypes From GWAS Catalog for TSPAN2 Gene

Gene Ontology (GO) - Molecular Function for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
genes like me logo Genes that share ontologies with TSPAN2: view
genes like me logo Genes that share phenotypes with TSPAN2: view

Animal Models for TSPAN2 Gene

MGI Knock Outs for TSPAN2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN2 Gene

Localization for TSPAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN2 gene
Compartment Confidence
plasma membrane 4
nucleus 4
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA 9714763
genes like me logo Genes that share ontologies with TSPAN2: view

Pathways & Interactions for TSPAN2 Gene

PathCards logo

SuperPathways for TSPAN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007420 brain development IEA --
GO:0014002 astrocyte development IEA --
GO:0014005 microglia development IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with TSPAN2: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN2 Gene

Drugs & Compounds for TSPAN2 Gene

No Compound Related Data Available

Transcripts for TSPAN2 Gene

mRNA/cDNA for TSPAN2 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for TSPAN2 Gene

GeneLoc Exon Structure for
TSPAN2

Expression for TSPAN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.5), Whole Blood (x5.0), Artery - Tibial (x4.4), and Uterus (x4.3).

Protein differential expression in normal tissues from HIPED for TSPAN2 Gene

This gene is overexpressed in Colon (16.6), Fetal Brain (12.6), Platelet (8.6), Peripheral blood mononuclear cells (7.2), and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN2

SOURCE GeneReport for Unigene cluster for TSPAN2 Gene:

Hs.310458

Evidence on tissue expression from TISSUES for TSPAN2 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with TSPAN2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN2 Gene

Orthologs for TSPAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN2 31 30
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN2 31 30
  • 91.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN2 31 30
  • 90.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan2 30
  • 88.99 (n)
mouse
(Mus musculus)
Mammalia Tspan2 17 31 30
  • 88.84 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN2 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN2 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN2 31 30
  • 69.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN2 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan2 30
  • 62.73 (n)
Str.12918 30
zebrafish
(Danio rerio)
Actinopterygii tspan2 31
  • 55 (a)
OneToMany
TSPAN2 (2 of 2) 31
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 31
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 31
  • 26 (a)
OneToMany
Species where no ortholog for TSPAN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN2 Gene

ENSEMBL:
Gene Tree for TSPAN2 (if available)
TreeFam:
Gene Tree for TSPAN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSPAN2: view image

Paralogs for TSPAN2 Gene

(12) SIMAP similar genes for TSPAN2 Gene using alignment to 3 proteins:

  • TSN2_HUMAN
  • B1AKP1_HUMAN
  • B1AKP2_HUMAN
genes like me logo Genes that share paralogs with TSPAN2: view

Variants for TSPAN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
769241 Benign: not provided 115,060,547(-) G/A INTRON_VARIANT
791110 Benign: not provided 115,058,974(-) C/A MISSENSE_VARIANT
rs9659602 - p.Arg118Leu

Additional dbSNP identifiers (rs#s) for TSPAN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TSPAN2 Gene

Variant ID Type Subtype PubMed ID
esv26121 CNV loss 19812545
esv3587278 CNV loss 21293372
nsv463295 CNV loss 19166990
nsv528883 CNV loss 19592680
nsv547570 CNV loss 21841781

Variation tolerance for TSPAN2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN2 Gene

Disorders for TSPAN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPAN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TSPAN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN2 Gene

Publications for TSPAN2 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd SC … Levy S (Biochimica et biophysica acta 1998) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F (Journal of cell science 2001) 2 3 54

Products for TSPAN2 Gene

Sources for TSPAN2 Gene