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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternat... See more...
Aliases for TSPAN2 Gene
Aliases for TSPAN2 Gene
External Ids for TSPAN2 Gene
- HGNC: 20659
- NCBI Entrez Gene: 10100
- Ensembl: ENSG00000134198
- OMIM®: 613133
- UniProtKB/Swiss-Prot: O60636
Previous GeneCards Identifiers for TSPAN2 Gene
- GC01M115303
- GC01M115590
- GC01M113448
Summaries for TSPAN2 Gene
-
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
GeneCards Summary for TSPAN2 Gene
TSPAN2 (Tetraspanin 2) is a Protein Coding gene. Diseases associated with TSPAN2 include Migraine, Familial Hemiplegic, 2 and Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations. An important paralog of this gene is CD9.
UniProtKB/Swiss-Prot Summary for TSPAN2 Gene
-
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
Additional gene information for TSPAN2 Gene
- HGNC (20659)
- NCBI Entrez Gene (10100)
- Ensembl (ENSG00000134198)
- OMIM® (613133)
- UniProtKB/Swiss-Prot (O60636)
- Open Targets Platform(ENSG00000134198)
- Monarch Initiative
- Search for TSPAN2 at DataMed
- Search for TSPAN2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN2 Gene
Genomics for TSPAN2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TSPAN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TSPAN2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN2
- Top Transcription factor binding sites by QIAGEN in the TSPAN2 gene promoter:
-
- FOXD3
- LUN-1
- Max1
- MAZR
- NRSF form 1
- NRSF form 2
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- POU6F1 (c2)
Genomic Locations for TSPAN2 Gene
Latest Assembly
- chr1:115,048,011-115,089,503
- (GRCh38/hg38)
- Size:
- 41,493 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:115,590,632-115,632,124
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 41,493 bases
- Orientation:
- Minus strand
- chr1:115,590,632-115,632,121
- (GRCh37/hg19 by Ensembl)
- Size:
- 41,490 bases
- Orientation:
- Minus strand
Genomic View for TSPAN2 Gene
Genes around TSPAN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
TSPAN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TSPAN2 Gene
Proteins for TSPAN2 Gene
-
Protein details for TSPAN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60636-TSN2_HUMAN
- Recommended name:
- Tetraspanin-2
- Protein Accession:
- O60636
- D6PTH4
- Q5TET2
- Q8WU05
Protein attributes for TSPAN2 Gene
- Size:
- 221 amino acids
- Molecular mass:
- 24148 Da
- Quaternary structure:
- No Data Available
Protein Expression for TSPAN2 Gene
Post-translational modifications for TSPAN2 Gene
Other Protein References for TSPAN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for TSPAN2
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-
Abcam antibodies for TSPAN2
- Invitrogen Antibodies for TSPAN2 (AFLGC-TSPAN2)
-
Biorbyt antibodies for TSPAN2
-
Custom Antibody ServicesProSci Antibodies for TSPAN2
- Sino Biological Antibodies for TSPAN2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TSPAN2
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- Novus Biologicals proteins for TSPAN2
- antibodies-online: Show 3 available TSPAN2 Proteins ranked by validation data
- Compare Top TSPAN2 Proteins
-
Quality Products:
-
Abcam proteins for TSPAN2
Assay products for research
No data available for DME Specific Peptides for TSPAN2 Gene
Domains & Families for TSPAN2 Gene
Gene Families for TSPAN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for TSPAN2 Gene
- InterPro:
- Blocks:
-
- Transmembrane four family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TSPAN2 Gene
- GenScript: Design optimal peptide antigens:
-
- Tetraspanin 2 (B1AKP2_HUMAN)
- Tetraspan NET-3 (TSN2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60636- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for TSPAN2 Gene
Molecular function for TSPAN2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
Phenotypes From GWAS Catalog for TSPAN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25814554 |
Phenotypes for TSPAN2 Gene
- MGI mutant phenotypes for TSPAN2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TSPAN2:
Animal Models for TSPAN2 Gene
- MGI Knock Outs for TSPAN2:
-
- Tspan2 Tspan2<tm1Hbw>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TSPAN2 - Starting at $85 >
- * TSPAN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TSPAN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TSPAN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN2
miRNA for TSPAN2 Gene
- miRTarBase miRNAs that target TSPAN2
-
- mmu-miR-7b-5p (MIRT009435)
- mmu-miR-340-5p (MIRT010641)
- mmu-miR-26a-5p (MIRT011413)
- mmu-let-7b-5p (MIRT012259)
- mmu-miR-19b-3p (MIRT012608)
- mmu-miR-297a-5p (MIRT013152)
- mmu-miR-30e-5p (MIRT013461)
- mmu-miR-136-5p (MIRT015063)
- hsa-miR-1277-5p (MIRT509180)
- hsa-miR-297 (MIRT509181)
- hsa-miR-3924 (MIRT509182)
- hsa-miR-190a-3p (MIRT509183)
- hsa-miR-4789-5p (MIRT509184)
- hsa-miR-3941 (MIRT509185)
- hsa-miR-223-5p (MIRT509186)
- hsa-miR-567 (MIRT509187)
- hsa-miR-511-3p (MIRT509188)
- hsa-miR-5011-5p (MIRT509189)
- hsa-miR-603 (MIRT509190)
- hsa-miR-362-3p (MIRT509191)
- hsa-miR-329-3p (MIRT509192)
- hsa-miR-8485 (MIRT509193)
- hsa-miR-4742-3p (MIRT520444)
- hsa-miR-452-3p (MIRT520445)
- hsa-miR-1185-2-3p (MIRT520446)
- hsa-miR-1185-1-3p (MIRT520447)
- hsa-let-7f-2-3p (MIRT520448)
- hsa-miR-1284 (MIRT520449)
- hsa-miR-664a-3p (MIRT520450)
- hsa-miR-6074 (MIRT520451)
- hsa-miR-5683 (MIRT520452)
- hsa-miR-4282 (MIRT541940)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TSPAN2
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Clone products for research
- Applied Biological Materials (abm): Clones for TSPAN2 - Starting at $45 >
- * TSPAN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TSPAN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TSPAN2
Cell Lines for research
-
Horizon Cell Lines for TSPAN2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN2 Gene
Localization for TSPAN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSPAN2 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,TAS | 9714763 |
Pathways & Interactions for TSPAN2 Gene
Interacting Proteins for TSPAN2 Gene
Selected Interacting proteins:
O60636-TSN2_HUMAN
ENSP00000358529
for TSPAN2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TSPAN2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
| GO:0014002 | astrocyte development | IEA | -- |
| GO:0014005 | microglia development | IEA | -- |
| GO:0042552 | myelination | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TSPAN2 Gene
Transcripts for TSPAN2 Gene
mRNA/cDNA for TSPAN2 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369515 793 nts (view in UCSC)
- ENST00000369516 3216 nts (view in UCSC)
- ENST00000433172 671 nts (view in UCSC)
- ENST00000491992 464 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TSPAN2 - Starting at $85 >
- * TSPAN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TSPAN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TSPAN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TSPAN2
- Browse OriGene Inhibitory RNA Products For TSPAN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN2
Clone products for research
- Applied Biological Materials (abm): Clones for TSPAN2 - Starting at $45 >
- * TSPAN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TSPAN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TSPAN2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | - |
Relevant External Links for TSPAN2 Gene
- GeneLoc Exon Structure for
- TSPAN2
Expression for TSPAN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TSPAN2 Gene
This gene is overexpressed in Colon - Sigmoid (x5.5), Whole Blood (x5.0), Artery - Tibial (x4.4), and Uterus (x4.3).
This gene is overexpressed in Colon (16.6), Fetal Brain (12.6), Platelet (8.6), Peripheral blood mononuclear cells (7.2), and Prostate (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN2
SOURCE GeneReport for Unigene cluster for TSPAN2 Gene:
Hs.310458Evidence on tissue expression from TISSUES for TSPAN2 Gene
- Kidney(4.3)
Primer products for research
-
OriGene qPCR primer pairs for TSPAN2
-
OriGene qPCR primer pairs and template standards for TSPAN2
Gene Expression Assays for research
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN2 Gene
Orthologs for TSPAN2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TSPAN2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TSPAN2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TSPAN2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tspan2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tspan2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TSPAN2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TSPAN2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TSPAN2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TSPAN2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tspan2 30 |
|
||
| Str.12918 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | tspan2 31 |
|
OneToMany | |
| TSPAN2 (2 of 2) 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp96F 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | tsp-9 31 |
|
OneToMany |
- Species where no ortholog for TSPAN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TSPAN2 Gene
- ENSEMBL:
- Gene Tree for TSPAN2 (if available)
- TreeFam:
- Gene Tree for TSPAN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TSPAN2: view image
Paralogs for TSPAN2 Gene
Paralogs for TSPAN2 Gene
(12) SIMAP similar genes for TSPAN2 Gene using alignment to 3 proteins:
- TSN2_HUMAN
- B1AKP1_HUMAN
- B1AKP2_HUMAN
Variants for TSPAN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs189737200 | Benign: not provided | 115,060,547(-) |
G/A NM_005725.6(TSPAN2):c.271-9C>T |
INTRON | |
| rs9659602 | Benign: not provided. - | 115,058,974(-) |
C/Ap.Arg118Leu NM_005725.6(TSPAN2):c.353G>T (p.Arg118Leu) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.70;
46.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TSPAN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TSPAN2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN2 Gene
Disorders for TSPAN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| migraine, familial hemiplegic, 2 |
|
|
| vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations |
|
|
| spastic paraplegia 2, x-linked |
|
|
| migraine, familial hemiplegic, 1 |
|
|
| hypertrophic neuropathy of dejerine-sottas |
|
|
Search TSPAN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TSPAN2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN2 Gene
Publications for TSPAN2 Gene
- Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd SC … Levy S (Biochimica et biophysica acta 1998) 2 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F (Journal of cell science 2001) 2 3
ExternalLinks
Products for TSPAN2 Gene
- Custom Antibody ServicesOriGene Antibodies for TSPAN2
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- Sino Biological Antibodies for TSPAN2
- Browse Sino Biological Assays
- Browse Antibodies
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for TSPAN2
- Novus Biologicals proteins for TSPAN2
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for TSPAN2 (AFLGC-TSPAN2)
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- antibodies-online: Show 20 available TSPAN2 Antibodies ranked by validation data
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- antibodies-online: Search results for available TSPAN2 related products ranked by validation data
- antibodies-online: Show 3 available TSPAN2 Proteins ranked by validation data
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- Quality Products:
- Custom Antibody ServicesProSci Antibodies for TSPAN2
- Search for TSPAN2 Proteins at ProSci
- Horizon Cell Lines for TSPAN2
- Browse GeneCopoeia Cell Lines
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- Biorbyt antibodies for TSPAN2
Sources for TSPAN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB