Aliases for TSPAN18 Gene

Aliases for TSPAN18 Gene

  • Tetraspanin 18 2 3 5
  • Tetraspanin-18 3 4
  • Tspan-18 3 4
  • TSPAN 2 3
  • TSPAN18 5

External Ids for TSPAN18 Gene

Previous GeneCards Identifiers for TSPAN18 Gene

  • GC11P044838
  • GC11P044496

Summaries for TSPAN18 Gene

GeneCards Summary for TSPAN18 Gene

TSPAN18 (Tetraspanin 18) is a Protein Coding gene. An important paralog of this gene is TSPAN9.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN18 Gene

Genomics for TSPAN18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TSPAN18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J044725 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 256.2 +1.2 1238 5.7 ZBTB10 NR2C1 CTCF BHLHE40 ZIC2 SIN3A REST ZNF740 VEZF1 TRIM22 TSPAN18 5EW4_A-010 EXT2 TSPAN18-AS1 TP53I11
GH11J044905 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 254.9 +179.7 179698 3.1 TAL1 EBF1 TCF12 ARID1B KLF1 CBFA2T2 ZNF766 MNT CBFA2T3 TSPAN18 lnc-SYT13-9 HSALNG0083897 TP53I11
GH11J044861 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +136.2 136174 3.1 SP1 BCL11A HES1 BHLHE40 ZIC2 ZNF395 CTCF MAX VEZF1 IRF4 TSPAN18 HSALNG0083897 TP53I11 piR-33164-005
GH11J044759 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.1 +37.3 37336 8 IKZF1 BHLHE40 ZIC2 ZNF395 CTCF GABPA TAL1 TAF9B EBF1 MYNN piR-33164-005 TSPAN18 EXT2 HSALNG0083897 TP53I11
GH11J044779 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +53.9 53936 3.2 MNT IKZF1 HES1 BHLHE40 ZEB1 NONO CEBPB ARNT ZNF395 VEZF1 TSPAN18 piR-33164-005 HSALNG0083897 TP53I11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN18

Top Transcription factor binding sites by QIAGEN in the TSPAN18 gene promoter:
  • AML1a
  • Chx10
  • Egr-1
  • Egr-3
  • Egr-4
  • LyF-1
  • NF-1
  • Pax-4a
  • POU3F2

Genomic Locations for TSPAN18 Gene

Latest Assembly
205,959 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
205,463 bases
Plus strand

(GRCh37/hg19 by Ensembl)
205,958 bases
Plus strand

Genomic View for TSPAN18 Gene

Genes around TSPAN18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN18 Gene

Proteins for TSPAN18 Gene

  • Protein details for TSPAN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UY44
    • Q8NBI9

    Protein attributes for TSPAN18 Gene

    248 amino acids
    Molecular mass:
    27710 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11690.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPAN18 Gene

Post-translational modifications for TSPAN18 Gene

  • Glycosylation at Asn111 and Asn129

No data available for DME Specific Peptides for TSPAN18 Gene

Domains & Families for TSPAN18 Gene

Gene Families for TSPAN18 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN18 Gene

  • Transmembrane four family signature

Suggested Antigen Peptide Sequences for TSPAN18 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspanin 18, isoform CRA_e (Q8WUV1_HUMAN)
  • Tetraspanin-18 (TSN18_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN18: view

Function for TSPAN18 Gene

Phenotypes From GWAS Catalog for TSPAN18 Gene

genes like me logo Genes that share phenotypes with TSPAN18: view

Animal Models for TSPAN18 Gene

MGI Knock Outs for TSPAN18:

Animal Models for research

  • Taconic Biosciences Mouse Models for TSPAN18

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN18

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN18 Gene

Localization for TSPAN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN18 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN18 gene
Compartment Confidence
plasma membrane 4
nucleus 3
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TSPAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN18 Gene

Pathways & Interactions for TSPAN18 Gene

PathCards logo

SuperPathways for TSPAN18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN18 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSPAN18 Gene

Drugs & Compounds for TSPAN18 Gene

No Compound Related Data Available

Transcripts for TSPAN18 Gene

mRNA/cDNA for TSPAN18 Gene

9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN18

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN18 Gene

No ASD Table

Relevant External Links for TSPAN18 Gene

GeneLoc Exon Structure for

Expression for TSPAN18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN18 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.7) and Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for TSPAN18 Gene

This gene is overexpressed in Fetal Brain (20.0), Cerebral cortex (6.9), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN18 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN18

SOURCE GeneReport for Unigene cluster for TSPAN18 Gene:


Evidence on tissue expression from TISSUES for TSPAN18 Gene

  • Nervous system(3.9)
  • Heart(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TSPAN18: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN18 Gene

Orthologs for TSPAN18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN18 30 31
  • 99.6 (n)
(Bos Taurus)
Mammalia TSPAN18 30 31
  • 92.98 (n)
(Canis familiaris)
Mammalia TSPAN18 30 31
  • 91.26 (n)
(Monodelphis domestica)
Mammalia TSPAN18 31
  • 90 (a)
(Mus musculus)
Mammalia Tspan18 30 17 31
  • 87.1 (n)
(Rattus norvegicus)
Mammalia Tspan18 30
  • 87.1 (n)
(Ornithorhynchus anatinus)
Mammalia TSPAN18 31
  • 87 (a)
(Gallus gallus)
Aves TSPAN18 30 31
  • 76.25 (n)
(Anolis carolinensis)
Reptilia TSPAN18 31
  • 83 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tspan18 30
  • 71.52 (n)
Str.15520 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398586 30
(Danio rerio)
Actinopterygii tspan18b 30 31
  • 73.44 (n)
tspan18a 31
  • 67 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Tsp66E 31
  • 27 (a)
(Caenorhabditis elegans)
Secernentea tsp-11 31
  • 20 (a)
tsp-13 31
  • 15 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5127 31
  • 41 (a)
-- 31
  • 37 (a)
CSA.10827 31
  • 36 (a)
CSA.8143 31
  • 35 (a)
CSA.4407 31
  • 31 (a)
CSA.10478 31
  • 29 (a)
-- 31
  • 28 (a)
Species where no ortholog for TSPAN18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TSPAN18 Gene

Gene Tree for TSPAN18 (if available)
Gene Tree for TSPAN18 (if available)
Evolutionary constrained regions (ECRs) for TSPAN18: view image

Paralogs for TSPAN18 Gene

(21) SIMAP similar genes for TSPAN18 Gene using alignment to 8 proteins:

  • E9PL40_HUMAN
  • H0YB98_HUMAN
genes like me logo Genes that share paralogs with TSPAN18: view

Variants for TSPAN18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN18 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs34282417 Benign: not provided 44,909,757(+) C/T
NM_130783.5(TSPAN18):c.116C>T (p.Thr39Ile)
rs34695714 Benign: not provided 44,926,712(+) C/T
NM_130783.5(TSPAN18):c.654C>T (p.Tyr218=)
rs2291334 - p.Val133Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TSPAN18 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TSPAN18 Gene

Variant ID Type Subtype PubMed ID
esv2744420 CNV deletion 23290073
esv28960 CNV gain 19812545
esv3626170 CNV loss 21293372
nsv1042139 CNV loss 25217958
nsv304 CNV deletion 18451855
nsv482977 CNV gain 15286789
nsv510252 OTHER sequence alteration 20534489
nsv554184 CNV loss 21841781
nsv832140 CNV loss 17160897

Variation tolerance for TSPAN18 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN18 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN18 Gene

Disorders for TSPAN18 Gene

Additional Disease Information for TSPAN18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TSPAN18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN18 Gene

Publications for TSPAN18 Gene

  1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue WH … Zhang D (Nature genetics 2011) 3 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for TSPAN18 Gene

Sources for TSPAN18 Gene