TSPAN17 Gene (Protein Coding)

Tetraspanin 17

GC05P176647
GIFtS:
34
This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014] See more...

Aliases for TSPAN17 Gene

Aliases for TSPAN17 Gene

  • Tetraspanin 17 2 3 5
  • F-Box Only Protein 23, Transmembrane 4 Superfamily Member 17 2 3
  • Tetraspan Protein SB134 3 4
  • Tetraspanin-17 3 4
  • TM4SF17 3 4
  • FBXO23 3 4
  • Transmembrane 4 Superfamily Member 17 4
  • F-Box Only Protein 23 4
  • Tspan-17 4
  • FBX23 3

External Ids for TSPAN17 Gene

Previous HGNC Symbols for TSPAN17 Gene

  • FBXO23
  • TM4SF17

Previous GeneCards Identifiers for TSPAN17 Gene

  • GC05P176008
  • GC05P176074
  • GC05P170998

Summaries for TSPAN17 Gene

Entrez Gene Summary for TSPAN17 Gene

  • This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for TSPAN17 Gene

TSPAN17 (Tetraspanin 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot Summary for TSPAN17 Gene

Additional gene information for TSPAN17 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN17 Gene

Genomics for TSPAN17 Gene

GeneHancer (GH) Regulatory Elements for TSPAN17 Gene

Promoters and enhancers for TSPAN17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN17 gene promoter:
  • AP-2gamma
  • NRSF form 1
  • NRSF form 2
  • p53
  • Pax-2
  • Pax-2a
  • SRF (504 AA)

Genomic Locations for TSPAN17 Gene

Genomic Locations for TSPAN17 Gene
chr5:176,647,387-176,659,058
(GRCh38/hg38)
Size:
11,672 bases
Orientation:
Plus strand
chr5:176,074,388-176,086,059
(GRCh37/hg19)
Size:
11,672 bases
Orientation:
Plus strand

Genomic View for TSPAN17 Gene

Genes around TSPAN17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN17 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TSPAN17 Gene

Proteins for TSPAN17 Gene

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  2. Protein
  3. Assay

  • Protein details for TSPAN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FV3-TSN17_HUMAN
    Recommended name:
    Tetraspanin-17
    Protein Accession:
    Q96FV3
    Secondary Accessions:
    • Q6NXF7
    • Q96S98
    • Q9UKB9

    Protein attributes for TSPAN17 Gene

    Size:
    270 amino acids
    Molecular mass:
    30264 Da
    Quaternary structure:
    • Interacts with ADAM10.
    SequenceCaution:
    • Sequence=AAF04524.1; Type=Frameshift; Positions=66, 81, 83; Evidence={ECO:0000305};

    Alternative splice isoforms for TSPAN17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN17 Gene

Post-translational modifications for TSPAN17 Gene

  • Glycosylation at Asn51 and Asn171

Other Protein References for TSPAN17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPAN17 Gene

Domains & Families for TSPAN17 Gene

Gene Families for TSPAN17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN17 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPAN17 Gene

GenScript: Design optimal peptide antigens:
  • FLJ00016 protein (Q9H7Q1_HUMAN)
  • Transmembrane 4 superfamily member 17 (TSN17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FV3

UniProtKB/Swiss-Prot:

TSN17_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN17: view

Function for TSPAN17 Gene

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  2. CRISPR
  3. miRNA
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  6. Cell Line

Molecular function for TSPAN17 Gene

UniProtKB/Swiss-Prot Function:
Regulates ADAM10 maturation.

Phenotypes From GWAS Catalog for TSPAN17 Gene

Gene Ontology (GO) - Molecular Function for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN17: view
genes like me logo Genes that share phenotypes with TSPAN17: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN17

CRISPR Products

miRNA for TSPAN17 Gene

miRTarBase miRNAs that target TSPAN17

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN17 Gene

Localization for TSPAN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN17 gene
Compartment Confidence
plasma membrane 4
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN17: view

Pathways & Interactions for TSPAN17 Gene

PathCards logo

SuperPathways for TSPAN17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0051604 protein maturation IBA 21873635
GO:0072594 establishment of protein localization to organelle IDA 23091066
genes like me logo Genes that share ontologies with TSPAN17: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN17 Gene

Drugs & Compounds for TSPAN17 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TSPAN17 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TSPAN17 Gene

(5) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(232) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN17

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - - - - - - -
SP8:

Relevant External Links for TSPAN17 Gene

GeneLoc Exon Structure for
TSPAN17
ECgene alternative splicing isoforms for
TSPAN17

Expression for TSPAN17 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN17 Gene

mRNA expression in normal human tissues for TSPAN17 Gene
mRNA expression by GTEx for TSPAN17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TSPAN17 Gene:

TSPAN17

SOURCE GeneReport for Unigene cluster for TSPAN17 Gene:

Hs.532129

Evidence on tissue expression from TISSUES for TSPAN17 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with TSPAN17: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN17 Gene

Orthologs for TSPAN17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TSPAN17 33 32
  • 99.29 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TSPAN17 33 32
  • 95.56 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia TSPAN17 33
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tspan17 17 33 32
  • 91.36 (n)
rat
(Rattus norvegicus)
 Mammalia Tspan17 32
  • 91.36 (n)
dog
(Canis familiaris)
 Mammalia TSPAN17 33 32
  • 90.83 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TSPAN17 33
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TSPAN17 33
  • 87 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tspan17 32
  • 78.27 (n)
zebrafish
(Danio rerio)
 Actinopterygii tspan17 32
  • 78.02 (n)
TSPAN17 33
  • 78 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Tsp26A 33 32
  • 57.16 (n)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea tsp-12 33
  • 36 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 41 (a)
 OneToMany
Species where no ortholog for TSPAN17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN17 Gene

ENSEMBL:
Gene Tree for TSPAN17 (if available)
TreeFam:
Gene Tree for TSPAN17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSPAN17: view image

Paralogs for TSPAN17 Gene

Paralogs for TSPAN17 Gene

(16) SIMAP similar genes for TSPAN17 Gene using alignment to 7 proteins:

  • TSN17_HUMAN
  • C9J7R4_HUMAN
  • D6RBW9_HUMAN
  • D6RDX8_HUMAN
  • D6RI03_HUMAN
  • H0Y9A5_HUMAN
  • J3KNG2_HUMAN

Pseudogenes.org Pseudogenes for TSPAN17 Gene

genes like me logo Genes that share paralogs with TSPAN17: view

Variants for TSPAN17 Gene

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Sequence variations from dbSNP and Humsavar for TSPAN17 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000153661 -- 176,648,525(+) C/T intron_variant
rs1000214522 -- 176,653,799(+) T/C intron_variant
rs1000275022 -- 176,651,335(+) A/G intron_variant
rs1000401913 -- 176,646,544(+) C/T upstream_transcript_variant
rs1000486767 -- 176,659,273(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN17 Gene

Variant ID Type Subtype PubMed ID
nsv462556 CNV loss 19166990
nsv600346 CNV loss 21841781
nsv600347 CNV loss 21841781

Variation tolerance for TSPAN17 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN17 Gene

Human Gene Mutation Database (HGMD)
TSPAN17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN17 Gene

Disorders for TSPAN17 Gene

Additional Disease Information for TSPAN17

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TSPAN17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN17 Gene

Publications for TSPAN17 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 56
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56

ExternalLinks

View latest publications for TSPAN17 gene in Mastermind

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