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Aliases for TSPAN16 Gene

Aliases for TSPAN16 Gene

  • Tetraspanin 16 2 3 5
  • Transmembrane 4 Superfamily Member 16 2 3 4
  • Tetraspanin TM4-B 3 4
  • Tetraspanin-16 3 4
  • Tspan-16 3 4
  • TM4SF16 3 4
  • TM4-B 3
  • TM-8 3

External Ids for TSPAN16 Gene

Previous HGNC Symbols for TSPAN16 Gene

  • TM4SF16

Previous GeneCards Identifiers for TSPAN16 Gene

  • GC19P011406
  • GC19P010986

Summaries for TSPAN16 Gene

Entrez Gene Summary for TSPAN16 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for TSPAN16 Gene

TSPAN16 (Tetraspanin 16) is a Protein Coding gene. An important paralog of this gene is TSPAN1.

Additional gene information for TSPAN16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN16 Gene

Genomics for TSPAN16 Gene

GeneHancer (GH) Regulatory Elements for TSPAN16 Gene

Promoters and enhancers for TSPAN16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011295 Promoter 0.7 EPDnew 600.7 +0.0 2 0.1 RAD21 CTCF TSPAN16 ENSG00000267174 HSPC102
GH19J011317 Promoter/Enhancer 1.7 Ensembl ENCODE 24.6 +25.8 25761 8.6 MTA3 ZFX ELF3 ZNF148 ZNF121 CEBPG NFIB BACH1 TFE3 SP7 ENSG00000267576 HSPC102 ENSG00000267174 TSPAN16 ILF3 TIMM29 ZNF844 ZNF433 ZNF627 KRI1
GH19J011360 Promoter/Enhancer 1.2 Ensembl ENCODE 11.8 +65.9 65934 1.9 SP1 GLIS2 RXRA ZIC2 REST POLR2A ZNF341 NRF1 SCRT2 MGA RGL3 PLPPR2 EPOR TSPAN16 SWSAP1
GH19J011447 Promoter/Enhancer 0.9 EPDnew dbSUPER 12 +151.4 151397 0.1 ZNF513 EGR2 PRKCSH EPOR ELAVL3 TSPAN16 KANK2 CCDC151 GC19M011460
GH19J011457 Enhancer 0.7 Ensembl dbSUPER 12.1 +161.5 161461 0.4 ZNF148 ZNF692 REST ZFP69B ELAVL3 TSPAN16 EPOR SWSAP1 CCDC159 ENSG00000267174 GC19M011460 CCDC151
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN16 gene promoter:
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RORalpha2

Genomic Locations for TSPAN16 Gene

Genomic Locations for TSPAN16 Gene
30,858 bases
Plus strand
30,849 bases
Plus strand

Genomic View for TSPAN16 Gene

Genes around TSPAN16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN16 Gene

Proteins for TSPAN16 Gene

  • Protein details for TSPAN16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • K7EN22
    • K7EPD8
    • Q8N6J7

    Protein attributes for TSPAN16 Gene

    245 amino acids
    Molecular mass:
    26266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN16 Gene


neXtProt entry for TSPAN16 Gene

Post-translational modifications for TSPAN16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TSPAN16 Gene

Domains & Families for TSPAN16 Gene

Gene Families for TSPAN16 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN16 Gene

Suggested Antigen Peptide Sequences for TSPAN16 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane 4 superfamily member 16 (TSN16_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN16: view

Function for TSPAN16 Gene

Phenotypes From GWAS Catalog for TSPAN16 Gene

Phenotypes for TSPAN16 Gene

genes like me logo Genes that share phenotypes with TSPAN16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN16 Gene

Localization for TSPAN16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN16 gene
Compartment Confidence
plasma membrane 4
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 10500248
genes like me logo Genes that share ontologies with TSPAN16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN16 Gene

Pathways & Interactions for TSPAN16 Gene

PathCards logo

SuperPathways for TSPAN16 Gene

No Data Available

Interacting Proteins for TSPAN16 Gene

Gene Ontology (GO) - Biological Process for TSPAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN16: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN16 Gene

Drugs & Compounds for TSPAN16 Gene

No Compound Related Data Available

Transcripts for TSPAN16 Gene

mRNA/cDNA for TSPAN16 Gene

Unigene Clusters for TSPAN16 Gene

Tetraspanin 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN16

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN16 Gene

No ASD Table

Relevant External Links for TSPAN16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN16 Gene

mRNA differential expression in normal tissues according to GTEx for TSPAN16 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for TSPAN16 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN16 Gene

Protein tissue co-expression partners for TSPAN16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSPAN16 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN16 Gene:


mRNA Expression by UniProt/SwissProt for TSPAN16 Gene:

Tissue specificity: Broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues.

Evidence on tissue expression from TISSUES for TSPAN16 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TSPAN16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN16 Gene

Orthologs for TSPAN16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSPAN16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN16 35 34
  • 98.77 (n)
(Canis familiaris)
Mammalia TSPAN16 34
  • 81.15 (n)
(Bos Taurus)
Mammalia TSPAN16 35
  • 70 (a)
Species where no ortholog for TSPAN16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSPAN16 Gene

Gene Tree for TSPAN16 (if available)
Gene Tree for TSPAN16 (if available)
Evolutionary constrained regions (ECRs) for TSPAN16: view image

Paralogs for TSPAN16 Gene

(4) SIMAP similar genes for TSPAN16 Gene using alignment to 5 proteins:

  • K7EN22_HUMAN
  • Q8N6J7_HUMAN
genes like me logo Genes that share paralogs with TSPAN16: view

Variants for TSPAN16 Gene

Sequence variations from dbSNP and Humsavar for TSPAN16 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000046177 -- 11,299,151(+) C/A/G/T intron_variant
rs1000077410 -- 11,299,338(+) A/T intron_variant
rs1000192517 -- 11,324,606(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000239102 -- 11,320,009(+) GGGG/GGGGG genic_downstream_transcript_variant, intron_variant
rs1000323193 -- 11,305,705(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN16 Gene

Variant ID Type Subtype PubMed ID
esv2659694 CNV deletion 23128226
esv3643668 CNV loss 21293372
esv3643669 CNV loss 21293372
esv3643670 CNV loss 21293372
nsv1116300 CNV deletion 24896259
nsv519802 CNV loss 19592680
nsv578615 CNV loss 21841781
nsv833752 CNV loss 17160897

Variation tolerance for TSPAN16 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN16 Gene

Disorders for TSPAN16 Gene

Additional Disease Information for TSPAN16

No disorders were found for TSPAN16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN16 Gene

Publications for TSPAN16 Gene

  1. The molecular characterisation of a novel tetraspanin protein, TM4-B(1). (PMID: 10500248) Puls KL … Wright MD (Biochimica et biophysica acta 1999) 2 3 4 58
  2. Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues. (PMID: 29654220) Zhang W … Qu S (Molecular pharmacology 2018) 3 58
  3. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D … Pajukanta P (Journal of medical genetics 2013) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for TSPAN16 Gene

Sources for TSPAN16 Gene

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