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Aliases for TSPAN15 Gene

Aliases for TSPAN15 Gene

  • Tetraspanin 15 2 3 5
  • Transmembrane 4 Superfamily Member 15 2 3 4
  • Tetraspan NET-7 3 4
  • Tspan-15 3 4
  • TM4SF15 3 4
  • NET7 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-7 3
  • Tetraspanin-15 3
  • 2700063A19Rik 3
  • NET-7 3

External Ids for TSPAN15 Gene

Previous HGNC Symbols for TSPAN15 Gene

  • TM4SF15

Previous GeneCards Identifiers for TSPAN15 Gene

  • GC10P070882
  • GC10P071211
  • GC10P065211

Summaries for TSPAN15 Gene

Entrez Gene Summary for TSPAN15 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN15 Gene

TSPAN15 (Tetraspanin 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN33.

UniProtKB/Swiss-Prot for TSPAN15 Gene

  • Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.

Additional gene information for TSPAN15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN15 Gene

Genomics for TSPAN15 Gene

GeneHancer (GH) Regulatory Elements for TSPAN15 Gene

Promoters and enhancers for TSPAN15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J069445 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 693.7 +24.4 24375 9 PKNOX1 FOXA2 NEUROD1 SIN3A ZNF213 ZNF143 FOS SP3 CEBPZ NFYC TSPAN15 DDX50 CCAR1 DDX21 TYSND1 FAM241B VPS26A TACR2 AIFM2 GC10M069447
GH10J069425 Enhancer 1.4 Ensembl ENCODE dbSUPER 672.3 +0.9 892 2 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 FOS ATF7 NFKBIZ TSPAN15 FAM241B ENSG00000231748 HK1 TACR2 GC10M069434
GH10J069423 Enhancer 1.1 Ensembl ENCODE dbSUPER 673.7 -1.0 -952 1.2 HDAC1 ELF3 MEIS2 TFAP4 PKNOX1 USF1 ATF1 ZSCAN4 ZKSCAN1 FOSL1 TSPAN15 FAM241B HK1 ENSG00000231748 TACR2
GH10J069436 Enhancer 1.2 Ensembl ENCODE dbSUPER 38.9 +13.6 13628 4.4 ELF3 PKNOX1 NEUROD1 SIN3A RCOR1 FOS DEK SMARCC1 CEBPB ELF1 TSPAN15 FAM241B HK1 ENSG00000231748 ATP5MC1P7 GC10M069447
GH10J069456 Enhancer 1.2 Ensembl ENCODE dbSUPER 35.8 +34.1 34135 5.6 NFIB RCOR1 FOS EGR2 CEBPB REST NR2F2 ZNF217 MTA1 KLF16 TSPAN15 GC10M069447 ATP5MC1P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN15 gene promoter:
  • SRF
  • SRF (504 AA)
  • GATA-1
  • c-Myb
  • CUTL1
  • E47
  • Hand1
  • HNF-4alpha1

Genomic Locations for TSPAN15 Gene

Genomic Locations for TSPAN15 Gene
82,452 bases
Plus strand
56,200 bases
Plus strand

Genomic View for TSPAN15 Gene

Genes around TSPAN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN15 Gene

Proteins for TSPAN15 Gene

  • Protein details for TSPAN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UW79

    Protein attributes for TSPAN15 Gene

    294 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    • Interacts with ADAM10; the interaction influences ADAM10 substrate specificity.

neXtProt entry for TSPAN15 Gene

Post-translational modifications for TSPAN15 Gene

  • Glycosylation at posLast=230230, isoforms=189, and posLast=118118
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN15 Gene

No data available for DME Specific Peptides for TSPAN15 Gene

Domains & Families for TSPAN15 Gene

Gene Families for TSPAN15 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TSPAN15 Gene

Suggested Antigen Peptide Sequences for TSPAN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN15: view

Function for TSPAN15 Gene

Molecular function for TSPAN15 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.

Phenotypes From GWAS Catalog for TSPAN15 Gene

Gene Ontology (GO) - Molecular Function for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019899 enzyme binding IEA,IPI 23091066
genes like me logo Genes that share ontologies with TSPAN15: view
genes like me logo Genes that share phenotypes with TSPAN15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN15

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN15 Gene

Localization for TSPAN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN15 Gene

Cell membrane; Multi-pass membrane protein. Late endosome membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN15 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 3
nucleus 2
endoplasmic reticulum 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IDA,IEA 23091066
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TSPAN15: view

Pathways & Interactions for TSPAN15 Gene

SuperPathways for TSPAN15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008593 NOT regulation of Notch signaling pathway IMP 23091066
GO:0051604 protein maturation IMP,IEA 23091066
GO:0072659 protein localization to plasma membrane IMP 23091066
genes like me logo Genes that share ontologies with TSPAN15: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN15 Gene

Drugs & Compounds for TSPAN15 Gene

No Compound Related Data Available

Transcripts for TSPAN15 Gene

mRNA/cDNA for TSPAN15 Gene

Unigene Clusters for TSPAN15 Gene

Tetraspanin 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -

Relevant External Links for TSPAN15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN15 Gene

Protein differential expression in normal tissues from HIPED for TSPAN15 Gene

This gene is overexpressed in Frontal cortex (12.6), Pancreas (8.2), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN15 Gene

Protein tissue co-expression partners for TSPAN15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN15 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN15 Gene:


Evidence on tissue expression from TISSUES for TSPAN15 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with TSPAN15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN15 Gene

Orthologs for TSPAN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN15 34 33
  • 99.66 (n)
(Canis familiaris)
Mammalia TSPAN15 34 33
  • 91.38 (n)
(Bos Taurus)
Mammalia TSPAN15 34 33
  • 91.24 (n)
(Mus musculus)
Mammalia Tspan15 16 34 33
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Tspan15 33
  • 86.28 (n)
(Monodelphis domestica)
Mammalia TSPAN15 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN15 34
  • 72 (a)
(Gallus gallus)
Aves TSPAN15 34 33
  • 75.77 (n)
(Anolis carolinensis)
Reptilia TSPAN15 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan15 33
  • 68.05 (n)
Str.1562 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6438 33
(Danio rerio)
Actinopterygii tspan15 34 33
  • 66.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp3A 34
  • 30 (a)
Tsp86D 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for TSPAN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN15 Gene

Gene Tree for TSPAN15 (if available)
Gene Tree for TSPAN15 (if available)
Evolutionary constrained regions (ECRs) for TSPAN15: view image

Paralogs for TSPAN15 Gene

(6) SIMAP similar genes for TSPAN15 Gene using alignment to 2 proteins:

  • H7C285_HUMAN
genes like me logo Genes that share paralogs with TSPAN15: view

Variants for TSPAN15 Gene

Sequence variations from dbSNP and Humsavar for TSPAN15 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000039404 -- 69,536,795(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000043368 -- 69,493,103(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000052664 -- 69,548,368(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000108204 -- 69,542,406(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000111684 -- 69,453,780(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN15 Gene

Variant ID Type Subtype PubMed ID
esv2678828 CNV deletion 23128226
esv32737 CNV gain+loss 17666407
esv3623745 CNV gain 21293372
esv3623746 CNV loss 21293372
nsv467356 CNV loss 19166990
nsv508590 CNV deletion 20534489
nsv523004 CNV loss 19592680
nsv524063 CNV loss 19592680
nsv524514 CNV loss 19592680
nsv551454 CNV loss 21841781
nsv7021 CNV deletion 18451855

Variation tolerance for TSPAN15 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN15 Gene

Disorders for TSPAN15 Gene

Additional Disease Information for TSPAN15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TSPAN15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN15 Gene

Publications for TSPAN15 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F (Journal of cell science 2001) 2 3 58
  5. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V … Rubinstein E (Biochimica et biophysica acta 2000) 2 3 58

Products for TSPAN15 Gene

Sources for TSPAN15 Gene

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